As mulheres anarquistas na cidade de São Paulo: 1889-1930

Pós-graduação em História - FCHS

Técnica e humanismo na poesia de Michel Deguy

Conselho Nacional do Desenvolvimento Científico e Tecnológico (CNPq)

Clinical and molecular phenotype of Aicardi-Goutières syndrome

Aicardi-Goutières syndrome (AGS) is a genetic encephalopathy whose clinical features mimic those of acquired in utero viral infection. AGS exhibits locus heterogeneity, with mutations identified in genes encoding the 3′→5′ exonuclease TREX1 and the three subunits of the RNASEH2 endonuclease complex. To define the molecular spectrum of AGS, we performed mutation screening in patients, from 127 pedigrees, with a clinical diagnosis of the disease. Biallelic mutations in TREX1, RNASEH2A, RNASEH2B, and RNASEH2C were observed in 31, 3, 47, and 18 families, respectively. In five families, we identified an RNASEH2A or RNASEH2B mutation on one allele only. In one child, the disease occurred because of a de novo heterozygous TREX1 mutation. In 22 families, no mutations were found. Null mutations were common in TREX1, although a specific missense mutation was observed frequently in patients from northern Europe. Almost all mutations in RNASEH2A, RNASEH2B, and RNASEH2C were missense. We identified an RNASEH2C founder mutation in 13 Pakistani families. We also collected clinical data from 123 mutation-positive patients. Two clinical presentations could be delineated: an early-onset neonatal form, highly reminiscent of congenital infection seen particularly with TREX1 mutations, and a later-onset presentation, sometimes occurring after several months of normal development and occasionally associated with remarkably preserved neurological function, most frequently due to RNASEH2B mutations. Mortality was correlated with genotype; 34.3% of patients with TREX1, RNASEH2A, and RNASEH2C mutations versus 8.0% RNASEH2B mutation-positive patients were known to have died (P = .001). Our analysis defines the phenotypic spectrum of AGS and suggests a coherent mutation-screening strategy in this heterogeneous disorder. Additionally, our data indicate that at least one further AGS-causing gene remains to be identified. © 2007 by The American Society of Human Genetics. All rights reserved.

The Genome of Anopheles darlingi, the main neotropical malaria vector

Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vectorhuman and vectorparasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles- darlingi. © 2013 The Author(s).

Um estudo sobre a saúde do professor a partir da perspectiva da sociologia sensível de Michel Maffesoli

Pós-graduação em Educação Escolar - FCLAR

Vendredi ou Les Limbes du Pacifique de Michel Tournier: o mito de Robinson Crusoe inserido na narrativa contemporânea

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A formação do projeto teórico de Michel Pêcheux: de uma teoria geral das ideologias à análise do discurso

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Proposta de uma metodologia para projeto construção e adequação de tubo de sucção numa turbina Michel-Baki

Pós-graduação em Engenharia Mecânica - FEG

Entre Clio e Sophia: um mapeamento das relações entre história e filosofia através dos diálogos entre Michel Foucault e os historiadores dos annales

Pós-graduação em História - FCLAS

Da história enquanto crítica: abordagem do pensamento kantiano na tese complementar de Michel Foucault, Gênese e estrutura da antropologia de Kant (1961)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Genealogia de uma operação historiográfica: as apropriações dos pensamentos de Edward Palmer Thompson e de Michel Foucault pelos historiadores brasileiros na década de 1980

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Instituições, confinamento e relações de poder: questões metodológicas no pensamento de Michel Foucault

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Contribuições de Michel Foucault para analisar documentos e arquivos na judicialização/jurisdicionalização

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)