β-lactam antibiotics epitope mapping with STD NMR spectroscopy: A study of drug-human serum albumin interaction

Molecular recognition events are key issues in many biological processes. STD NMR (saturation transfer difference nuclear magnetic resonance spectroscopy) is one of the techniques used to understand such biological interactions. Herein, we have investigated the interactions of four β-lactam antibiotics belonging to two classes (cephalosporins and penicillins) with human serum albumin (HSA) by 1H STD NMR revealing that the interaction between the aromatic moiety and HSA is responsible for the binding efficiency. Thus, the structural differences from the five to six-membered thio ring in penicillins and cephalosporins do not seem to influence antibiotic-albumin interactions. © 2012 Sociedade Brasileira de Química.

Influenza among the elderly in the Americas: A consensus statement

Influenza exacts a heavy burden on the elderly, a segment of the population that is estimated to experience rapid growth in the near future. In the past decade most developed and several developing countries have recommended influenza vaccination for those > 65 years of age. The World Health Organization (WHO) set a goal of 75% influenza vaccination coverage among the elderly by 2010, but it was not achieved. In 2011, the Technical Advisory Group at the Pan American Health Organization, Regional Office of WHO for the Americas, reiterated the influenza vaccine recommendation for older adults. Relatively little information has been compiled on the immunological aspect of aging or on reducing its impact, information particularly relevant for clinicians and gerontologist with firsthand experience confronting its effects. To fill this data gap, in 2012 the Americas Health Foundation (Washington, D.C., United States) and the nonprofit, Fighting Infectious Diseases in Emerging Countries (Miami, Florida, United States), convened a panel of Latin American clinicians and gerontologists with expertise in influenza to discuss key issues and develop a consensus statement. The major recommendations were to improve influenza surveillance throughout Latin America so that its impact can be quantified; and to conduct laboratory confirmation of influenza for all patients who have flu-like symptoms and are frail, immunosuppressed, have comorbidities, are respiratory compromised, or have been admitted to a hospital. The panel also noted that: since evidence for antivirals in the elderly is unclear, their use should be handled on a case-by-case basis; despite decreased immunological response, influenza vaccination in older adults is still crucial; indirect immunization strategies should be encouraged; and traditional infection control measures are essential in long-term care facilities.

Drogas, violência e políticas sociais: estudo de uma comunidade terapêutica

Pós-graduação em Ciências Sociais - FFC

Diretrizes de práticas para transferência de tecnologia de gestão entre Clusters industriais

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O Índice de Desenvolvimento da Educação Básica (IDEB): um estudo do município de Santa Fé do Sul (SP)

Pós-graduação em Educação - FFC

Construção de estatutos de ciência para a biologia numa perspectiva histórico-filosófica: uma abordagem estruturante para seu ensino

Pós-graduação em Educação para a Ciência - FC

Metadata Authority Description Schema (MADS): uma alternativa à utilização do formato MARC 21 para dados de autoridade

Introduction: Authority records interchange requires establishing and using metadata standards, such as MARC 21 Format for Authority Data, format used by several cataloging agencies, and Metadata Authority Description Schema (MADS), that has received little attention and it is a little widespread standard among agencies. Purpose: Presenting an introductory study about Metadata Authority Description Schema (MADS). Methodology: Descriptive and exploratory bibliographic research. Results: The paper address the MADS creation context, its goals and its structure and key issues related to conversion of records from MARC 21 to MADS. Conclusions: The study concludes that, despite its limitations, MADS might be used to create simple authority records in Web environment and beyond libraries context.

Empresariado industrial e desenvolvimento socioeconômico: estudo do discurso do empresariado calçadista paulista frente ao mundo globalizado (1995-2010)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Gramática: reflexões sobre um percurso de elaboração de manuais

As part of a round table entitled “Construction of descriptive grammars”, with authors of descriptive grammars of the Portuguese language, this text presents a personal refl ection that seeks to recover the key issues that have challenged me in this kind of work. In order to do this, I recover the historical route of the decisions I took in the construction of two manuals of Portuguese grammar and, at the same time, I gather, in other works I have written, information that can explain the guidelines adopted. Being consistent with my background and with my praxis, I offer some thoughts towards the fundamental proposition I have always considered such works to have, which is the school destination, something I can summarize in the question of what should constitute a work with the “grammar” at school.

Protocolos de natação em modelos experimentais com ratos

Exercise physiology has attempted to reproduce the experimental exercise in the laboratory using mainly rats. The swimming exercise has emerged as one of the leading research in these type ergometers. Thus, this research consisted of a literature review addressing the key issues which involve the exercise of swimming in the model rats. Training of aerobic and anaerobic swimming, evaluation models and models of periodization were the topics suggested in this research. In several studies, models of aerobic and anaerobic training have been proposed with the aim of studying their effect on normal and abnormal physiological parameters. However, earlier studies lacked methods of analysis aiming to determine the exercise intensity in the animal model. For this reason, in the last decade, assessment models have been adapted for humans to animals, especially rats. The maximal lactate steady state (MLSS) and lactate minimum (LM) are among the various techniques used to measure the amount of effort produced by swimming exercise in rats. Thereafter, based on biochemical parameters such as lactate, swimming exercise in rats has become the highest-rated, ie, using as reference the anaerobic threshold (AT). In another aspect, an entirely new line of research has tried to understand and promising swimming training in a periodized and its effects on some biochemical parameters. But this is an area little researched so far. Thus, the experimental model of swimming has proved an important resource of exercise physiology. From this model, it becomes possible to study the exercise, especially swimming, in more accurate, based on invasive and incisive analysis of the rat

In search of the autonomous and critical individual: a philosophical and pedagogical analysis of the physical education curriculum of São Paulo (Brazil)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Wavelet-galerkin method for computations of electromagnetic fields-computation of connection coefficients

One of the key issues which makes the waveletGalerkin method unsuitable for solving general electromagnetic problems is a lack of exact representations of the connection coefficients. This paper presents the mathematical formulae and computer procedures for computing some common connection coefficients. The characteristic of the present formulae and procedures is that the arbitrary point values of the connection coefficients, rather than the dyadic point values, can be determined. A numerical example is also given to demonstrate the feasibility of using the wavelet-Galerkin method to solve engineering field problems. © 2000 IEEE.

Direito à informação pela mídia virtual e a sua responsabilidade

Pós-graduação em Direito - FCHS

Classificação de anomalias e redução de falsos positivos em sistemas de detecção de intrusão baseados em rede utilizando métodos de agrupamento

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)