Estresse crônico melhora a função miocárdica sem alterar a atividade do canal-L para Ca+2 em ratos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cloning and Identification of a Complete cDNA Coding for a Bactericidal and Antitumoral Acidic Phospholipase A(2) from Bothrops jararacussu Venom

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

N-methyl-D-aspartate channel and consciousness: From signal coincidence detection to quantum computing

Research on Blindsight, Neglect/Extinction and Phantom limb syndromes, as well as electrical measurements of mammalian brain activity, have suggested the dependence of vivid perception on both incoming sensory information at primary sensory cortex and reentrant information from associative cortex. Coherence between incoming and reentrant signals seems to be a necessary condition for (conscious) perception. General reticular activating system and local electrical synchronization are some of the tools used by the brain to establish coarse coherence at the sensory cortex, upon which biochemical processes are coordinated. Besides electrical synchrony and chemical modulation at the synapse, a central mechanism supporting such a coherence is the N-methyl-D-aspartate channel, working as a 'coincidence detector' for an incoming signal causing the depolarization necessary to remove Mg 2+, and reentrant information releasing the glutamate that finally prompts Ca 2+ entry. We propose that a signal transduction pathway activated by Ca 2+ entry into cortical neurons is in charge of triggering a quantum computational process that accelerates inter-neuronal communication, thus solving systemic conflict and supporting the unity of consciousness. © 2001 Elsevier Science Ltd.

Influência do gênero e treinamento físico aeróbio sobre a modulação autonômica cardíaca, pressão arterial e biomarcadores de estado redox em mulheres na perimenopausa e homens

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Enzymatic and structural characterization of new PLA2 isoform isolated from white venom of Crotalus durissus ruruima

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Biochemical and functional properties of a thrombin-like enzyme isolated from Bothrops pauloensis snake venom

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The locus coeruleus and central chemosensitivity

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeito do manejo da entrelinha da seringueira sobre as propriedades químicas do solo, o estado nutricional e o crescimento

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Curva de crescimento e marcha de absorção de macronutrientes em três cultivares de amoreira (Morus alba L)

To evaluate the growth and pattern of nutrient absorption (N, P, K, Ca, Mg and S amongst others) in three berry cultivars (treatments), four plants by treatment in different phonological stages were harvested. The experiment was arranged in randomized design of factorial 3x5 with three replicates. There cultivars were used FM Shima-Miura, IZ 56/4 and Miura and above ground biomass was harvested in five occasions 45, 60, 75, 90 and 115 days after plantation. It was observed that the accumulation of nutrients presented different pattern and cv. IZ 56/4 was superior compared with PM Shima-Miura for N, P, K, Ca, Mg and S and N, P, K and S for Miura. For example, the accumulation of N expressed on mg plant"(1) per berry plant cultivar PM Shima-miura, IZ 56/4 and Miura was respectively 4,21; 8,14 and 5,56, for K 2,71; 5,22 and 2,64 and for Ca 2,47; 4,52 and 3,59.

Macronutrient accumulation and partioning in fertigated sweet pepper plants

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Organophosphorus-induced delayed neuropathy: A simple and efficient therapeutic strategy

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effects of calcium gluconate and PMSF in the treatment of acute intoxication of chicken by TOCP

To examine the efficacy of calcium gluconate (two doses of Ca-Glu 5 mg/kg i.v.) to alleviate the injurious effects of organophosphorus induced delayed neuropathy (OPIDN) in the presence or absence of phenylmethanesulfonyl fluoride (PMSF go mg/kg i.m.), 14 groups of four isabrown hens were used. To measure the lymphocyte neuropathy target esterase (LNTE)activity, groups receiving just distilled water (control), groups receiving just Tri-orto-cresyl phosphate (TOCP; 500 mg/kg p.o.) (Positive control), and other groups receiving TOCP and Ca-Glu or PMSF simultaneously or 12 hours later following intoxication by TOCP were used. They were sacrificed 12 and 24 hours after the administration of TOCP. To observe a 28-day time course of neurotoxicity scores and calcium plasma concentration, five groups were used. Regarding free Ca(2+)in the plasma, the positive control produced a characteristic profile time course up and down (luring 28 days, and some hens with maximum score of neurotoxicity in 28 days. The treatment, which prevented greater oscillation in free Ca(2+) in the plasma, presented a decrease in OPIDN in relation to the positive control. Twelve hours after the administration of TOCP, LNTE was 70-80% inhibited when compared with control, whereas the first decrease in the free Ca(2+) in the plasma was significantly different from the control only 24 hours after the administration of TOCP. In summary, the sooner the Ca-Glu is started, the less severe the neuropathy effects.

The semi-synthetic kaurane ent-16 alpha-methoxykauran-19-oic acid induces vascular relaxation and hypotension in rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Variabilidade espacial de atributos da fertilidade de um Latossolo Vermelho Distroférrico sob Sistema Plantio Direto

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)