306 resultados para Mathematical models. Circadian rhythms. Circadian timing system. Actigraphy
Resumo:
Pós-graduação em Engenharia Elétrica - FEIS
Resumo:
Pós-graduação em Engenharia Elétrica - FEIS
Resumo:
Pós-graduação em Engenharia Mecânica - FEG
Resumo:
Pós-graduação em Matematica Aplicada e Computacional - FCT
Resumo:
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Resumo:
Pós-graduação em Engenharia Elétrica - FEB
Resumo:
The pharmaceutical innovations, such as the use of polymers to control drug release, create possibilities for a better action of the drug in the body, which causes a a more effective therapeutic effect and a safer treatment for the patient. In this work, were prepared and characterized matrix tablets of hydroxypropylmethylcellulose (HPMC) containing nimesulide as model drug to evaluate the performance as a controlled release system. HPMC, a cellulose ester, is a hydrophilic polymer that undergoes swelling, i.e., absorbs water and forms a gel layer controlling drug release. The characterization of powders was performed by analysis of particle size and morphology, density, compressibility index determination, flow properties and determination of swelling profile. The tablets were evaluated according to their physical parameters of quality and to the in vitro release of nimesulide, as well as the analysis of the mechanisms of drug release by appropriate mathematical models. The set of results showed that the HPMC/Nimesulide mixture exhibited satisfactory physical characteristics (size, shape, density and flow). The release profile demonstrated an effective control upon drug release in enteric environment and presented more correlation with Korsmeyer-Peppas’ and Weibull’s mathematical models, indicating that the release of nimesulide occurs through the relaxation of the polymer chains
Resumo:
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Resumo:
Pós-graduação em Engenharia Elétrica - FEIS
Resumo:
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Resumo:
The purpose of this work was the study of numerical methods for differential equations of fractional order and ordinary. These methods were applied to the problem of calculating the distribution of the concentration of a given substance over time in a given physical system. The two compartment model was used for representation of this system. Comparison between numerical solutions obtained were performed and, in particular, also compared with the analytical solution of this problem. Finally, estimates for the error between the solutions were calculated
Resumo:
Pós-graduação em Engenharia Elétrica - FEIS
Resumo:
Pós-graduação em Engenharia Elétrica - FEIS
Resumo:
Pós-graduação em Engenharia Elétrica - FEIS
Resumo:
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)