Vertical transmission of hepatitis C virus: A tale of multiple outcomes

Globally, hepatitis C virus (HCV) infection affects approximately 130 million people and 3 million new infections occur annually. HCV is also recognized as an important cause of chronic liver disease in children. The absence of proofreading properties of the HCV RNA polymerase leads to a highly error prone replication process, allowing HCV to escape host immune response. The adaptive nature of HCV evolution dictates the outcome of the disease in many ways. Here, we investigated the molecular evolution of HCV in three unrelated children who acquired chronic HCV infection as a result of mother-to-child transmission, two of whom were also coinfected with HIV-1. The persistence of discrete HCV variants and their population structure were assessed using median joining network and Bayesian approaches. While patterns of viral evolution clearly differed between subjects, immune system dysfunction related to HIV coinfection or persistent HCV seronegativity stand as potential mechanisms to explain the lack of molecular evolution observed in these three cases. In contrast, treatment of HCV infection with PegIFN, which did not lead to sustained virologic responses in all 3 cases, was not associated with commensurate variations in the complexity of the variant spectrum. Finally, the differences in the degree of divergence suggest that the mode of transmission of the virus was not the main factor driving viral evolution. (C) 2013 Elsevier B. V. All rights reserved.

O dilema extensão universitária

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Diretrizes políticas e estratégicas para a formaçáo docente voltadas à pesquisa e à extensão: Brasil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

LUDIBUS, o ônibus da alegria: possibilidades de estágio extracurricular aliando ensino, pesquisa e extensão

This paper aims to present the Ludibus project, by Faculty of Philosophy and Science of Unesp, Marilia Campus, and placement possibilities offered by extracurricular work of teaching, research and extension education developed by his team. The Project is characterized by the existence of a playful bus, adapted to the development of artistic, recreational and literary schools in Basic Education (Early Childhood Education and Elementary Education, cycle I). It aims to contribute to the process of initial and continuing training of man and women teachers who will serve and act in Basic Education and to offer proposals for artistic and recreational activities for children of kindergarten and the early grades of elementary school, with a view to the creation, appreciation and reflection related to artistic languages and playful. We make use of action research and varied procedures in order to organize and provide activities related to the themes of the project the teachers and children. The results point to good learning opportunities and enriching experiences for the teacher training process, setting up the project in a privileged place for the occurrence of extracurricular period.

Como escutar os gritos de quem não consegue ler e escrever: percursos de um projeto de extensão desenvolvido pela UNESP

Data presented here is the result of an extension project developed by UNESP which aims to support children who complain about learning disabilities. These students with reading and writing problems were part on intervention sessions, individually and/or in small groups, in which different games and non-usual activities were implemented. These intervention sessions seek an improvement in the non-learning situation and, above all, a change in the relationship that the children have established with these school subjects. So far, the main results indicate a development in the mentioned areas and a significant improvement in the entire student learning condition, which were verified during the intervention sessions and by the teachers’ and parents’ reports, as well. We also present here reflections on the process of assessment and intervention and about the way these subjects are dealt at school, and the meaning of not learning how to read and how to write for a child.

Análise do curso de extensão em Libras, na modalidade a distância, para formação continuada de professores no contexto educacional inclusivo

The inclusive education policy implemented by state and municipal educational systems of Brazil, contemplates that students with hearing loss can study in regular education classes. In this context, the use and knowledge of the Brazilian sign language is essential. Therefore, in 2009, an extension course of Libras of 120 hours in distance mode was developed in partnership with the FFC / UNESP, funded by the Program for Continuing Education of Teachers, the SEESP - MEC for Brazilian public school teachers. In the presence of this reality, this research sought to examine the course content, the evaluation of teachers about it and also verify the impression of teachers on a course offered in distance mode. We analyzed: the course design, the scientific report and the evaluation sheets filled in by pupils. It was found that the course had three modules: introduction to distance education; theoretical reflection on the use of Libras in inclusive education, practical activities and the use of Libras. 548 public school teachers linked to 19 departments and/ or boards of education in various regions of Brazil participated in the study. The analysis showed that teachers evaluated the course satisfactorily, pointing out that they favored the interaction with deaf students. Regarding the use of the modality of distance learning, the teacher students had difficulties with the Internet, which hampered access to the materials. However, the teachers considered distance learning interesting, because they learned to tinker with previously unknown tools, and had the opportunity to hone their technology skills.

A extensão da racionalidade econômico-privatistica ao conhecimento produzido pela subjetividade emancipada: paradoxo da modernidade

This paper aims to present a study of the social relationships around the production, circulation and the eventual possibility of appropriation of knowledge in social systems of the pre-modern world and in a social organization of Western capitalist modernity. In this specific universe of relationships, it was also important to noticed that there is a paradoxical role of rationality that served to the emancipation of instruments of control’s knowledge of pre-modern period as in the same time it was favored by the construction of new bonds that were made in the Western modernity through the modern legal system, inserting the knowledge in the domain of the economy and private logic of the capitalist’s system through intellectual property. This research was made from a review of the literature, using specialized books of the theme. It was concluded that there is a paradox in the social relationships about the knowledge, whose cause is related to the unfolding of rationality in the development of Western civilization.

Three-point functions and su(1 vertical bar 1) spin chains

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)