Síntese e avaliação biológica de novos derivados anti-inflamatórios esteroides

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Busca de novos alvos terapêuticos no tratamento de câncer de pulmão utilizando ferramentas de biologia de sistemas

A quimioterapia e uma das formas de tratamentos para o câncer, cujo processo e pela aplicação de medicamentos que alteram a síntese de DNA, interrompendo a divisão celular. No caso do câncer de pulmão, a difículdade está no fato de que as células cancerígenas criam quimiorresistência após um determinado período de tempo. Se o indivíduo desenvolver o câncer de pulmão novamente, deverá ser aplicado outro quimioterápico no paciente, e assim por diante. Nos tratamentos atuais são utilizados combinações de drogas para contornar o problema da quimiorresistência. Este trabalho utilizou a biologia de sistemas para encontrar novos alvos protéicos para auxiliar no desenvolvimento de novos quimioterápicos para o tratamento do câncer de pulmão. Foi construída uma rede baseada nos alvos protéicos já conhecidos. A rede foi expandida com o intuito de buscar quais são as proteínas que interagem com os alvos protéicos á conhecidos. Após a expansão, foram utilizadas análises de centralidades para evidenciar as proteínas mais importantes na rede, e correlacionamos com informação de expressão gênica para verificar se as proteínas mais importantes do ponto de vista topológico estão diferencialmente sub ou super expressas. A análise de centralidade junto a mostra dos dados de expressão gênica convergiu para um bom resultado, foi possível evidenciar algumas proteínas que podem ser utilizadas como novos alvos quimioterápicos

Exigências ambientais europeias: novos desafios competitivos para o complexo eletrônico brasileiro

The objective of this paper is to evaluate the implications of the european environmental requirements for electronic equipment on brazilian electronic industry sector. These deter-minations deal with elimination of hazardous substances and management of electronic products waste and have reached not only the electronic sector companies in international level, but brazilian electronic sector as well. Most brazilian companies of the electronic sector are getting complied with the requirement that restricts the use of hazardous substances. The main consequences of this process are technological innovations and changes on contractual relationships among companies. Foreign companies branches are more advanced than local ones in terms of timing of compliance to the new requirements and technological perfor-mance, showing an alignment with headquarter strategies. Not being complied with these requirements avoid companies to achieve commercial benefits and open space for questions about policies Brazil must take.

Educação pública nas metrópoles brasileiras: impasses e novos desenlaces

O livro Educação Pública nas Metrópoles Brasileiras: impasses e novos desenlaces apresenta um conjunto de artigos sobre preconceitos que persistem nas práticas educacionais contemporâneas, sobretudo nas grandes cidades como São Paulo e Rio de Janeiro. De outra parte enfatiza como a teoria psicanalítica combinada com o método etnográfico, praticada em instituições educacionais, pode ser útil para a reconstrução de padrões de autoridade imprescindíveis ao ato educativo.

Políticas participativas e a nova literatura de análise de políticas públicas: novos horizontes para agenda de pesquisa

From the organization of social movements in the late 1960s to the institutionalization of participatory politics in the Brazilian Federal Constitution in 1998 , the research agenda on participatory institutions in Brazil was not only consolidated in the academic setting as been growing and diversifying in the past decades. The main objective of this paper is to put the most recent literature of policy process applied to studies of participatory institutions. This paper assumes that the public policy are multidisciplinary epistemological field of knowledge. Thus, it is through the explanation of some of his theories and models of the policy process analysis that we aims to show new perspectives for the research agenda on participatory institutions.

Considerações sobre a atualidade da formação cultural/educacional: novos desafios para a pesquisa

This paper aims to draw some outlines of what I understand to be background for possible investigations that examine the cultural / educational problems in Brazil from the perspective of Critical Theory. Under the light of these outlines I intend to present two directions of research which are the main objectives of the research project I develop within the Department of Educational Psychology of College of Sciences and Letters of Unesp in Araraquara. In particular, it is necessary to understand the internal deformation that education suffers as a concrete substance of the teaching process in schools, which makes an empirical investigation how the cultural industry’s schemes become present in the “didactic pedagogical scene” necessary. On the other hand, the elucidation of this problem requires a theoretical investigation about the broader process of constitution of today’s subjectivity under the impact of that industry. Both goals set forth herein are intended to provide subsidies to make readings about new educational demands possible in Brazil.

Crise de hegemonia e emergência de novos atores na Bolívia: o governo de Evo Morales

The presidency of Evo Morales, indigenous leader and who heads the party Movement Towards Socialism (MAS), opens a series of transformations in several dimensions. The changes in socio-economic and political power express the critic of long-term coloniality relations between a dominant white elite and an indigenous subordinate majority that deepens after national independence. Following this perspective, present in sectors of support to the government, the strategy of the MAS cannot follow the tradition of social revolutions that operated structural breaks in the mode of production and the state organization, but points to a new decolonizing revolution, cultural and political, articulating an indigenism of broad nature, flexible and open to popular social movements. This view is facing critics in sectors of the left that identify the renewal of capitalist modernization process initiated in 1952 under the leadership of the Nationalist Revolutionary Movement (MNR), extending citizenship and democratizing access to the state for recognition of Indians as such. From this perspective, the transformations proposed by MAS tend to favor a system restoration by diversifying its economic and social base. From the contrast provided by these two lines of interpretation, we intend to analyze the structural possibilities of the strategy of the government of Evo Morales, taking as historical reference the transformations wrought by the nationalist revolution of 1952 and the neoliberal reforms initiated in 1980.

Avaliação de novos híbridos de porta-enxertos para a laranjeira 'valência'

Pós-graduação em Agronomia (Horticultura) - FCA

Liberação controlada de nutrientes e novos sistemas para avaliação de espécies químicas empregadas na fertilização

Pós-graduação em Química - IQ

Adsorção-fotodegradação do herbicida paraquate em água pela argila Na-Bentonita e por novos materiais TiO2-Bentonita, TiO2/ZnOBentonita, Al/Fe-Bentonita e Al/Fe.Cu-Bentonita

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Quantificação eletroquímica de analitos de interesse ambiental e biológico, empregando novos materiais preparados a partir de silsesquioxanos funcionalizados

Pós-graduação em Ciência dos Materiais - FEIS

Preparação de novos nanobiocompósitos comestíveis ativos contendo nanoemulsão de canela e pectina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Novos rumos, velhos hábitos: debates acerca do trabalhador rural na Assembléia Nacional Constituinte Portuguesa de 1911

Pós-graduação em História - FCLAS

Preparação e caracterização de novos híbridos orgânicos-inorgânicos baseados em carboximetilcelulose/polifosfato de sódio dopados com 'Eu'Cl IND.3

Organic- inorganic hybrid (HOI) are materials prepared with the combination of inorganic and organic components. The properties of a hybrid material are unique, not being the sum of each individual component added. This occurs because there is a synergism that depends of the chemical nature of organic and inorganic components, of the size and morphology of their domains. The sodium carboxymethylcellulose (CMC) it's an anionic polymer obtained of the cellulose, very soluble in water in which forms both solutions themselves and gels. The sodium polyphosphate (NaPO3)n, known commercially as Graham Salt is the only polyphosphate soluble in water, and it's the polyphosphate with the longest chain. At the present work it was prepared and characterized new phosphate organic- inorganic hybrids films of carboxymethylcellulose / sodium phosphate and luminescent films of CMC/NaPO3 doped with europium chloride (EuCl3). The films where prepared in several proportions. At first, it was set the amount of water to be used and the amount of carboxymethylcellulose, changing the concentrations of sodium polyphosphate and europium chloride. After pre-establishing concentrations, for each film, the components were submitted to constant agitation and subsequent drying. The inorganic-organic hybrid films were characterized by, TG, DR-X, DMA, FT-IR, UV-Vis-NIR, RMN 31P e 13C and at last, a study of luminescence was made. The hybrid films obtained are transparent and macroscopically homogeneous, however, the MET measures showed the formation of micro-islands of polyphosphate along the material, this fact indicates a bigger fragmentation of the films and this is verified by DMA analysis which shows a smaller resistance of the film with the increase of the concentration of phosphate. Both spectrum FT-IR and RMN analysis of the films, don't show the formation of new bands of their precursors, CMC e NaPO3,....

O que os homens têm a dizer sobre as mulheres? Os novos posicionamentos de jovens do gênero masculino frente às transformações femininas nas relações afetivas: uma leitura sob a ótica da Psicologia Analítica

Pós-graduação em Educação Sexual - FCLAR