VEGF-C expression in oral cancer by neurotransmitter-induced activation of beta-adrenergic receptors

The aim of this study was to investigate the expression of vascular endothelial growth factor type C (VEGF-C) in oral squamous cell carcinoma (OSCC) cell lines through norepinephrine-induced activation of beta-adrenergic receptors. Human OSCC cell lines (SCC-9 and SCC-25) expressing beta-adrenergic receptors were stimulated with different concentrations of norepinephrine (0.1, 1, and 10 μM) and 1 μM of propranolol, and analyzed after 1, 6, and 24 h. VEGF-C gene expression and VEGF-C production in the cell supernatant were evaluated by real-time PCR and by ELISA, respectively. The results showed that beta-adrenergic receptor stimulation by different concentrations of norepinephrine or blocking by propranolol did not markedly alter VEGF-C expression by SCC-9 and SCC-25 cells. VEGF-C protein levels produced by oral malignant cell lines after stimulation with different norepinephrine concentrations or blocking with propranolol was statistically similar (p > 0.05) to those of the control group (nonstimulated OSCC cell lines). Our findings suggest that stimulation of beta-adrenergic receptors by means of norepinephrine does not seem to modulate the VEGF-C expression in OSCC cell lines. These findings reinforce the need for further studies in order to understand the responsiveness of oral cancer to beta-adrenergic receptor stimulation or blockage, especially with regard to VEGF-C production. © 2012 International Society of Oncology and BioMarkers (ISOBM).

Desenvolvimento de interface amigável de rotina em linguagem c++ para o processamento aritmético e estatístico de dados censitários

A routine was developed in C++ for the processing of social and environmental census data acquired by the Brazilian Institute of Geography and Statistics (IBGE). The routine employs a simple graphical environment. The data generated are presented in a tabular format, which facilitates a broad and objective view of the values, and provides a convenient means of querying the database. The source code used to develop the routine permits updates and changes, as required by the user. Statistical and mathematical analysis enables the generation of social and environmental indicators, together with quantitative and qualitative classification of the socio-environmental quality of the region analyzed. As an example, the routine was applied using census data for the city of Sorocaba (São Paulo State, Brazil), including conditions of household occupation, water supply, sanitation, level of education, income, and other factors. It is envisaged that the proposed analytical model will assist professionals from different fields of research and teaching to develop urban planning and management strategies.

Fuzzy control embedded in microcontroller and applied to an experimental apparatus using magnetorheological fluid damper

This work focuses on applying fuzzy control embedded in microcontrollers in an experimental apparatus using magnetorheological fluid damper. The non-linear behavior of the magnetorheological dampers associated with the parametric variations on vehicle suspension models corroborate the use of the fuzzy controllers. The fundamental formulation of this controller is discussed and its performance is shown through numeric simulations. An experimental apparatus representing a two degree of freedom system containing a magnetorheological damper is used to identify the main parameters and to evaluate the performance of the closed-loop system with the embedded low-cost microcontroller-based fuzzy controller. © 2013 Brazilian Society for Automatics - SBA.

BCS: A Binary Cuckoo Search algorithm for feature selection

Feature selection has been actively pursued in the last years, since to find the most discriminative set of features can enhance the recognition rates and also to make feature extraction faster. In this paper, the propose a new feature selection called Binary Cuckoo Search, which is based on the behavior of cuckoo birds. The experiments were carried out in the context of theft detection in power distribution systems in two datasets obtained from a Brazilian electrical power company, and have demonstrated the robustness of the proposed technique against with several others nature-inspired optimization techniques. © 2013 IEEE.

Classificação da curvatura de vertentes em perfil via Thin Plate Spline e Inferência Fuzzy

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Detecção e classificação de faltas de alta impedância em sistemas elétricos de potência usando lógica Fuzzy

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Classificação fuzzy de vertentes por krigagem e TPS com agregação de regiões via diagrama de Voronoi

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Utilização do controle estatístico de processo na unidade de produção e desenvolvimento de derivados de soja - UNISOJA - F.C.F. - UNESP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito de tratamentos térmicos na resistência à tração e na dureza Vickers do Ti c.p. e da liga Ti-6Al-4V obtidos por fundição odontológica

Pós-graduação em Reabilitação Oral - FOAR

Kappa-PSO-ARTMAP Fuzzy: uma metodologia para detecção de intrusos baseado em seleção de atributos e otimização de parâmetros numa rede neural ARTMAP Fuzzy

Pós-graduação em Engenharia Elétrica - FEIS

Implementação de um sistema para geração e avaliação de movimentos em pacientes hemiplégicos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aspectos de topologia e mutação no processo de enovelamento e evolução de proteínas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da atividade dos óleos essenciais de cymbopogon citratus (D.C.) Stapf, Tagetes minuta L. e Curcuma zedoaria roscoe frente aos microrganismos Candida spp., Staphylococcus spp. e Streptococcus mutans

Pós-graduação em Biopatologia Bucal - ICT

Resposta humoral, carga parasitária e avaliação histopatológica na infecção experimental por Leishmania (Leishmania) chagasi em camundongos BALB/c imunossuprimidos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Modelagem e controle de sistemas fuzzy Takagi-Sugeno

Pós-graduação em Engenharia Elétrica - FEIS