128 resultados para 368
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A análise histórica sobre a realização do Rock in Rio (Rio de Janeiro, 1985), evento musical que contou com bandas e cantores nacionais e internacionais, permite trazer, além de dados históricos sobre a inédita concretização de um megaevento musical no Brasil, elementos de compreensão acerca da discussão sobre o Festival bem como o próprio rock nacional oitentista no período de redemocratização política brasileira. Pois, as críticas ao Rock in Rio partiram tanto de membros da Igreja Católica quanto perpassaram o campo musical e político, sempre respaldadas, aliás, em reações em defesa da “autêntica” música brasileira contra a “invasão” do rock, bem como sobre o suposto teor alienante e alienado das esferas e estruturas do rock. Além disso, este artigo busca refletir sobre mais um velho-novo gênero musical nos primeiros e mancos passos da redemocratização política brasileira.
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Objetivou-se com este estudo avaliar as perdas fermentativas, composição bromatológica e digestibilidade in vitro da matéria orgânica de silagens de milho produzidas em diferentes estádios de maturidade, inoculadas microbiologicamente. Aplicaram-se dois inoculantes comerciais nas silagens produzidas nos estádios SLL, 1/3 LL, 1/2 LL, 2/3 LL e CN, permanecendo ainda um tratamento sem inoculação (silagem controle), configurando um esquema fatorial 3x5. A inoculação com BAL resultou em menores perdas fermentativas (P=0,0348), ao passo que silagens produzidas com plantas mais secas também apresentam menores perdas de MS (P<0,01). A inoculação das silagens resultou em maiores concentrações de PB nas silagens produzidas nos estádios SLL, 2/3 LL e CN (P=0,0033). O uso do inoculante Maize All® resultou em menor concentração de FDN (P=0,0140) no estádio CN e acréscimo dos coeficientes de DIVMO quando as plantas foram colhidas com 2/3 LL e CN (P=0,0006). As perdas fermentativas diminuem devido à utilização dos inoculantes bacterianos e também em silagens produzidas com plantas mais secas. A aplicação de bactérias ácido-láticas (inoculante Maize All®) em silagens de milho produzidas com plantas em estádio de maturidade mais avançado melhora a composição química e digestibilidade in vitro.
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INTRODUCTION: Basketball is characterized with high injury rate. In the literature it's not defined whether or not there are differences between the sexes. OBJECTIVE: Characterize and analyze the incidence of athletic injuries in basketball players, comparing the sexes. MATERIALS AND METHODS: Fifteen under-23 category athletes of each sex were interviewed with the reported morbidity inquire. RESULTS: The age of the female and male teams, in average, was 18 ± 0.65 and 18.20 ± 1.57 years respectively. The male team had more injuries than the female one (respectively 2.6 ± 1.45 against 1.2 ± 1.18, p < 0.05). The joint damage was the most common injury in the male team, representing 58.97%, and the second most common in the female team (33.33%). The lower limbs were the most common injured sites (80.95% in the female and 69.23% in the male). The most frequent injury mechanism in the male team was the landing (43.59%), and in the female was the vertical jump (28.57%). In both teams the most injuries occurred during the training (61.9% in the female and 71.8% in the male). The absence was necessary in 47.62% (female) and 56.41% (male). Great part of the athletes didn't received any treatment (61.9% and 51.28% in the female and male team respectively). The return to the activities was mostly symptomatic, in both female and male team (85.71% and 84.62% respectively). CONCLUSION: The incidence of injuries in basketball is higher in the lower limbs. The male team is more likely to suffer injuries, and the main injury mechanisms were different between male and female team.
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INTRODUCTION: Patients treated with nitrogen-containing bisphosphonates, such as zoledronic acid (ZA), have frequently shown oral bone exposure areas, termed osteonecrosis. In addition, these patients may also present low repair and regeneration potential, mainly after tooth extractions. These side-effects caused by bisphosphonates may be due to their inhibitory effects on oral mucosa and local bone cells. OBJECTIVE: To evaluate the effects of ZA on the mineralization capacity of cultured osteoblasts. MATERIALS AND METHODS: Human immortalized osteoblasts (SaOs-2) were grown in plain culture medium (Dulbecco's Modified Eagle Medium [DMEM] + 10% fetal bovine serum [FBS]) in wells of 24-well plates. After 48-hour incubation, the plain DMEM was replaced by a solution with ZA at 5 µM which was maintained in contact with cells for seven, 14 or 21 days. After these periods, cells were evaluated regarding alkaline phosphatase (ALP) activity and mineral nodule formation (alizarin red). Data were statistically analyzed by Mann-Whitney test, at 5% of significance level. RESULTS: ZA caused significant reduction on ALP activity and mineral nodules formation by cultured osteoblasts in all evaluated periods (p < 0.05). CONCLUSION: These data indicate that ZA causes inhibition on the osteogenic phenotype of cultured human osteoblasts, which, in turn, may reduce bone repair in patients subjected to ZA therapy.
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The aim of this study was to evaluate the growth performance of Brycon amazonicus larvae fed with probiotic consisting of Bacillus subtilis, bioencapsulated in Artemia salina at different doses. Six treatments were used: T0 = control (without probiotic), T2.5 = 2.5 g, T5.0 = 5.0 g, T7.5 = 7.5 g, T10.0 = 10.0 g and T12;5 = 12.5 g per liter of probiotic when fed with A. saline (4h before feeding the larvae); and per kilogram of feed (commercial powder with 40% crude protein) in the next phase. The results showed heterogeneity with regard to growth, indicating that larvae fed with probiotic had no influence on cannibalism.
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In this work we present an electrochemical study using carbon paste electrode (CPE) with CuFeS2 in solutions with different concentrations of Fe2+ ions in order to evaluate the possible interaction between these ions and mineral sulfide in the absence and presence of the bacteria Acidithiobacillus ferroxidans.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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The organization of the inclusive education is a slow and complex process, which has the necessity of investments in supports for all the scholar team. Aiming at spreading one of the actions carried out for the promotion of the inclusive educational practices in a municipal education system in a western city in the state of São Paulo, this paperwork has the objective of presenting an elaborated manual of orientations for the implementation of the individual curricular adaptations (ACIs) for students who demand special educational necessities (NEEs). The material was constituted on the basis of three data sets: 1) tabulation of the evaluations of the curricular adaptations already made; 2) the literature review; 3) analysis of the themes which have emerged during case discussion meetings mediated by the researchers with teachers from the Specialized Pedagogical Support Service (SAPE), with teachers and administrators from the common education system and the technical-pedagogical team. The final version of the manual contemplates the theoretical-operational aspects about the themes: flexibility and curricular adequation, inclusive education, definitions of NEEs, how SAPE works; and it finishes with a model proposal of ACI. It is expected that the spreading of this material can subside new curricular propositions for students with deficiency that are very distant from the academic level expected for the current scholar year.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Lung cancer is a leading cause of death in developed countries. Although smoking cessation is a primary strategy for preventing lung cancer, former smokers remain at high risk of cancer. Accordingly, there is a need to increase the efficacy of lung cancer prevention. Poor bioavailability is the main factor limiting the efficacy of chemopreventive agents. The aim of this study was to increase the efficacy of cancer chemopreventive agents by using lipid nanoparticles (NPs) as a carrier. This study evaluated the ability of lipid NPs to modify the pharmacodynamics of chemopreventive agents including N-acetyl-L-cysteine, phenethyl isothiocyanate and resveratrol (RES). The chemopreventive efficacy of these drugs was determined by evaluating their abilities to counteract cytotoxic damage (DNA fragmentation) induced by cigarette smoke condensate (CSC) and to activate protective apoptosis (annexin-V cytofluorimetric staining) in bronchial epithelial cells both in vitro and in ex vivo experiment in mice. NPs decreased the toxicity of RES and increased its ability to counteract CSC cytotoxicity. NPs significantly increased the ability of phenethyl isothiocyanate to attenuate CSC-induced DNA fragmentation at the highest tested dose. In contrast, this potentiating effect was observed at all tested doses of RES, NPs dramatically increasing RES-induced apoptosis in CSC-treated cells. These results provide evidence that NPs are highly effective at increasing the efficacy of lipophilic drugs (RES) but are not effective towards hydrophilic agents (N-acetyl-L-cysteine), which already possess remarkable bioavailability. Intermediate effects were observed for phenethyl isothiocyanate. These findings are relevant to the identification of cancer chemopreventive agents that would benefit from lipid NP delivery.