Signs, translation, and life in the Bakhtin circle and in Welby's significs

“Significs” is provisionally defined by Welby (1911: vii) as the study of the nature of significance in all its forms and relationships, of its workings in all spheres of human life and knowledge. Considering “significs” as a movement highlighting significance, Welby explores the action of signs in life; and more than the Saussurean sign composed of signifier and signified, the sign as understood by Welby refers to meaning as generated through signs in motion. This notion of “significs” empowers the study of signs when it considers the sign not in terms of the Saussurean structural representation of the union of the concept and acoustic image, but as (responsive and responsible) sign action in the world, in life. This also means to take into account the “extra-linguistic referent” (translinguistic and transdiscursive character of significs), history (space-time), subjectivity, the architecture of values connected to language, their communicative function. We believe that a dialogue can be established between Welby’s vision of significs and the notion of ideological sign proposed by Vološinov in Marxism and the Philosophy of Language, expanding the notions of “meaning” and “sense.”

Empacotamento de experimentos controlados em engenharia de software: uma abordagem baseada em ontologia

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Apoio à execução de experimentos controlados usando uma ontologia para empacotamento: a ferramenta OntoExpTool

Pós-graduação em Ciência da Computação - IBILCE

ITScan: a web-based analysis tool for Internal Transcribed Spacer (ITS) sequences

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Validation of absolute quantitative real-time PCR for the diagnosis of streptococcus agalactiae in fish

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento da ferramenta MS2PSOC: Tradução de modelos descritos no matlab/simulink para o ambiente psoc creator

Pós-graduação em Engenharia Elétrica - FEIS

Tradução para o português brasileiro, adaptação transcultural e validação do 3D Assessment of Hand Function

Pós-graduação em Bases Gerais da Cirurgia - FMB

Geotecnologias aplicadas à análise do assoreamento de reservatórios de hidrelétricas em cenário de escassez de dados de séries históricas

Pós-graduação em Engenharia Mecânica - FEG

A simulation tool for transient stability analysis on vector computers

This paper deals with transient stability analysis based on time domain simulation on vector processing. This approach requires the solution of a set of differential equations in conjunction of another set of algebraic equations. The solution of the algebraic equations has presented a scalar as sequential set of tasks, and the solution of these equations, on vector computers, has required much more investigations to speedup the simulations. Therefore, the main objective of this paper has been to present methods to solve the algebraic equations using vector processing. The results, using a GRAY computer, have shown that on-line transient stability assessment is feasible.

Subtitling as a pedagogical tool for language teaching in journalism

This study was designed to present and discuss some results produced by a research involving the use of English subtitles of some news videos from the webiste Reuters.com (http://www.reuters.com) with pedagogical reasons in a Brazilian context (Academic English for Journalism). We have developed the research during two semesters at UNESP (Universidade Estadual Paulista Júlio de Mesquita Filho). The professor in charge of the study has chosen the students of Journalism as the audience to whom the videos were presented. The assumptions of many theorists and experts in Audiovisual Translation were adopted as our Theoretical Sources. The first step of the study was the assessment of the syllabus of each course. This was very helpful as a guidance in order to choose the most relevant and interesting videos for students. After the evaluation of academic and professional interests, we chose some videos to insert appropriate subtitles, according to some strategies suggested by Panayota Georgakopoulou and Henrik Gottlieb. Finally we presented the videos during the English classes. At the first time, they were presented without subtitles just to notice the comprehension level of the students. After that, the videos were presented with English subtitles. As we first assumed, the students haven’t had the whole comprehension of specific details during the first presentation, they have just used their previous knowledge and the visual aids to help them in a superficial understanding of the news. As the subtitles appear, the process of communication was finally accomplished.

Role of ATM and PTEN in prostatic carcinogenic dog prostate: validation of aCGH results

The canis lupus familiares is the only species besides human that spontaneously develop prostatic carcinoma (PCa). In addition, the metastatic sites are similar to those frequently reported in men. For these reasons, the dog is the best natural model to study the molecular mechanisms in PCa development providing a natural animal model for treatment by molecular targets. Previously, we investigated copy number alterations by arrayCGH (Canine Genome CGH Microarray 4x44K-G2519F, Agilent Technologies) in canine prostatic lesions: 3 benign prostatic hyperplasias (BPH), 4 proliferative inflammatory atrophies (PIA), and 14 PCa. Five histologically normal prostatic tissues were used as reference. Genomic alterations were evaluated using Genomic Workbench Standard Edition 5.0.14. This previous study revealed significant copy number losses of Atm and Pten exclusively in PCa. In the present study, ATM and PTEN immunoexpression were investigated using a tissue microarray (TMA) containing 149 canine prostatic paraffin-embedded lesions (BPH, PIA and PCa) collected from 67 animals. Immunohistochemical reactions were performed using the polyclonal rabbit antibody anti-PTEN (Santa Cruz Biotech, 1:50) and anti-ATM (Abcam, 1:50). The sections were developed with diaminobenzidine (DAB) and peroxidase. The immunohistochemical staining was assessed in each core by the distribution of positive cells for each antibody per lesion (score 1: <25% cells positive, 2: 26% to 50%, 3: being 51% and 75% and 4:> 75%) and intensity (1: weak, 2: moderate, 3: intense). Chi-square or Fisher exact test was used to determine the association between the categorical variables using GraphPad Prism 5 (GraphPad Software Inc., La Jolla, CA). Distribution of positive cells did not differ among lesions. PCa and PIA showed more samples with weak intensity for ATM when compared to normal prostatic tissue and BPH (PCa: p=0,032 and PIA: p=0,025). Benign prostatic hyperplasia and normal samples presented intense PTEN immunostaining than PCa (p=0,021) and PIA (p=0,0013). These results suggest that ATM and PTEN proteins expression in canine prostatic carcinoma are downregulated possibly by copy number losses. These findings are similar from those described in prostate carcinomas from human corroborating for the use of dogs as a natural model to study prostatic disease in men.

Identificação e análise do vocabulário acadêmico em língua inglesa presente em textos acadêmico-científicos

Pós-graduação em Estudos Linguísticos - IBILCE

Desenvolvimento de software para avaliação dos desempenhos hidráulico e econômico de pivôs centrais

Pós-graduação em Agronomia (Proteção de Plantas) - FCA