Avaliação do Efeito Fotodinâmico sobre o Crescimento in vitro de Pythium insidiosum

Photodynamic Therapy (PDT) is a therapeutic method which employs a photosensitizer and light to cause cellular death. The chemical compounds have low or none toxicity for hosts cells. Under the incidence of light, in an appropriated wavelength, these chemical compounds produce reactive oxygen which affects the biomolecules of the target-cells. The specific illumination of the affected area increases the selectivity of the therapy, since the photodynamic process occurs only in the irradiated area. Pythiosis, for instance, is a life-threatening emerging disease caused by a fungus-like organism called Pythium insidiosum. The disease occurs in man and other animals, being mostly observed in horses. Human pythiosis may present as ophthalmic, cutaneous-subcutaneous and systemic forms of lesions. Due to the fact that P. insidiosum is not a true fungus, it is refractory to most antifungal drugs and the treatment of the disease is difficult. Extensive surgery procedures, such as limb amputation, are the treatment of choice, however relapses may occur frequently. Although not totally effective, the use of immunotherapy associated to surgery have shown some results. Considering that pythiosis is an emerging disease few explored in its etiological and therapeutic aspects, which are limited and few effective, it is of great importance to encourage the development of researches for new strategies of treatment. In this sense, it was evaluated the effect of PDT on in vitro growth of the pathogen employing two chemical compounds as photosensitizer, porphyrin and chlorine, at different concentrations in combination with several energetic dosages. Porphyrin showed inhibition of growth at 25mg/mL with 100J/cm2 of energetic dosage and chlorine showed similar results employing low concentrations (0,7, 1,0 and 1,3mg/mL) with 70J/cm2 of energetic dosage... (Complete abstract click electronic access below)

Caracterização do padrão eletroforético de glândulas salivares de Triatoma lecticularia e Rhodnius prolixus (Hemiptera, Reduviidae, Triatominae) em diferentes tempos pós repasto sanguíneo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Narrativas Multimodais: a imagem dos matemáticos em performances matemáticas digitais

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O Mestre, de Ana Hatherly: uma insólita aprendizagem

O mestre (1963), written by the Portuguese author Ana Hatherly, continues to challenge our reading due to its disturbing nature. The text is not only connected to and transcends the emerging modernity of the Portuguese poetic avant- -garde experimental proposals of the period, presenting itself as a permanent intriguing text. This paper examines the narrative procedures put into action in order to destabilize the relationship I – the Other (master and apprentice), multiform agents, producers of metamorphosis and disturbing actions. The female narrator addresses love, truth, knowledge and power in an uncommon way and transforms the narrative into a magic practice, with surprising effects.

Estudo sobre desruptores endócrinos em sistemas aquáticos: detecção e perspectivas de tratamento das águas do Rio Aporé-MS/GO, utilizando-se adsorventes sólidos

Pós-graduação em Ciência dos Materiais - FEIS

Allelopathic potential and survey of natural seed bank under the canopy of Copaifera Langsdorffii Desf

The aim of this study was to evaluate the allelopathic effect of soil samples collected under the canopies of three specimens of Copaifera langsdorffii the germination of Lactuca sativa and survey the natural seed bank according to seasonality. To test the allelopathic effect was carried experiments of pre and post-emergence with seeds of L. sativa and to quantify the stock of seeds, soil samples were collected from three specimens at three distances from the stem (1, 2 and 3 m) and at three depths (0-5, 5-10 and 10-15cm) in the region of savanna in the dry and wet seasons. The samples tested in bioassay of pre-emergence no significant influence on germinability, mean germination time and mean germination speed, but showed a difference in the synchronism of germination, these data were independent of sampling station. In test for post-emergence was observed statistical difference in the parameters evaluate (length of primary roots and hypocotyls) in both seasons. To quantify the natural seed bank were macroscopic analysis of each soil sample with the help of stereoscopic microscope. The analysis of the natural seed bank showed a larger number of seeds in the 0-5cm and in distance of 2m for both seasons. The results suggest the presence of allelochemical substances in soil samples collected under the canopy of Copaifera langsdorffii.

A lousa digital interativa no ensino fundamental: um estudo de caso de uma escola municipal brasileira

The main objective of this paper is to realize a review of literature about use of Interactive Digital Whiteboard, as a tool for improving the quality of education. We intend to show some results already reported in several studies in this area, and thus contribute to the systematization of knowledge about this resource. We found that the positive impacts of digital interactive whiteboards are specific and depend on the model followed in its implementation. Although the literature on this technology still emerging, there is evidences of good practice and positive results in all areas of the curriculum. The outcome of this research shows that to get potential benefits of digital whiteboard will be necessary, at first, to understand the process implementation and appropriation. If hardware and software of Interactive Digital Whiteboard not available and adequately used all their potential benefits not will take effect.

Globalização, desemprego e (nova) pobreza: estudo sobre impactes nas sodiedades portuguesa e brasileira

This article reflects upon the possible connections between the processes of economic globalization, changes in the labour market and the new forms of poverty. The debate is framed by two different economic contexts: Portugal (characterized by slow and insufficient growth rates, a serious social crisis, and difficulties in asserting itself economically and politically in the European and world contexts) and Brazil (a dynamic emerging economy, with high growth rates and receding poverty levels). This allows us to assess some of the economic and social impacts arising from the global pressure to be economically competitive, which have led to new forms of poverty, social precariousness and job insecurity in both societies.

A Competência em informação para a construção de conhecimento no processo decisório: estudo de caso na Duratex de Agudos (SP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Relacionamentos amorosos na pós-modernidade: análise das consultas apresentadas em sites de relacionamento amoroso

The contemporary culture is based in a logic of acceleration and shortening of the relationships, a logic that disseminates and lodges in the subjectivity, so as to affect the most varied spheres of life. The purpose of the present work is to examine the conflicts that emerge in love relationships lived in such context. Seventy-four queries submitted by the users of two love-consultancy websites were taken as the object of our analysis. The complaints presented by the users were collated to the paradigms of relationship produced in the contemporary days. It was possible to observe that the modes of subjectification predominant nowadays can be apprehended in the love sphere of the human life and that from those modes derive most of the affective conflicts reported by people who seek advice in those websites. The sentimental hardship of these subjects denounces the ills of our days.

Produção de bioetanol de segunda geração pelo consórcio Zymomonas mobilis CCT4494 e Candida tropicallis em resíduos de uvas Isabel e Bordô

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Antibodies to Neospora caninum in sheep from slaughterhouses in the state of Sao Paulo, Brazil

Neosporosis is an emergent disease responsible for considerable economic impact due to reproductive losses. Its zoonotic potential remains unknown. This study involved a survey of antibodies to Neospora caninum in slaughtered sheep and their association with epidemiological variables. Serum samples from 596 sheep from the states of Sao Paulo and Rio Grande do Sul, Brazil, were collected in two slaughterhouses located in Sao Paulo and evaluated by indirect fluorescence antibody test (IFAT), using cut-off titers of 25. Among these samples, 353/596 (59.23%; 95%CI 55.23-63.10) were positive and 263/353 (74.50%; 95%CI 69.71-78.77%) were from Rio Grande do Sul. Statistical associations were determined in the univariate analysis between the serological results and sex, breed and municipality of origin. Sheep that came from extensive breeding system showed higher chance (OR=2.09) of presenting antibodies to N. caninum in relation to those from semi-intensive system. Higher chance was also observed for the different studied breeds, except Bergamacia, in relation to Hampshire Down. The results revealed the presence of infection by N. caninum in sheep from slaughterhouses.

Perfil de Aglutininas Anti-leptospira e anti-brucella e condições sanitárias de ovinos da região noroeste do Estado de São Paulo, Brasil

The sheep industry has become increasingly prominent in agribusiness, transforming the stage production of Brazil, and thus contributes more to the socio-economic development of the country. The work aimed to verify the occurrence of brucellosis and leptospirosis in sheep from northwestern São Paulo state. In addition to determining the prevalence of major Leptospira in the region and to trace the diagnosis of sheep breeding in this part of the country. All the 1222 sheep serum samples from 49 properties did not react serologically to evidentiary testing for brucellosis, compared to antigens of B. abortus and B. ovis used in the testing of 2-ME and IDGA, respectively. The Microscopic Agglutination Test (MAT) test revealed that 19.14% (232/1212) of samples were positive for one or more serovars, with titles ranging from 100 to 800. The most frequent serovar was hebdomadis in the region, with Sentot and Sherman (18.10%, 11.64% and 8.62%, respectively). By profiling the system of sheep farming in the region, we found that most herds are composed of more than one race being the main purpose is for the court. According to the scheme adopted immunoprophylactics there is a homogeneous set schedule. It adopts the use of anti-helminth, non-prescription veterinary antibiotic. There is also the presence of diarrhea and abortions and the lack of criteria for los ovinos on management, making it the need for emergency development of programs for disease control, schema immunoprophylactics adequate sanitation and hygienic measures in sheep breeding.

Fisiologia térmica e balanço hídrico em anfíbios anuros

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Realidade misturada: conceitos, ferramentas e aplicações

The Mixed Reality proposes scenes combining between virtual and real worlds offering to the user an intuitive way of interaction according to a specific application. This tutorial paper aims at presenting the fundamentals concepts of this emergent kind of human-computer interface.