Relationship between race and clinical characteristics, extent of disease, and response to chemotherapy in patients with low-risk gestational trophoblastic neoplasia

Objective. To evaluate the potential effects of race on clinical characteristics, extent of disease, and response to chemotherapy in women with postmolar low-risk gestational trophoblastic neoplasia (GTN).Methods. This non-concurrent cohort study was undertaken including patients with FIGO-defined postmolar low-risk GTN treated with comparable doses and schedules of chemotherapy at the New England Trophoblastic Disease Center (NETDC) between 1973 and 2012. Racial groups investigated included whites, African American and Asians. Information on patient characteristics and response to chemotherapy (need for second line chemotherapy, reason for changing to an alternative chemotherapy, number of cycles/regimens, need for combination chemotherapy, and time to hCG remission) was obtained.Results. Of 316 women, 274 (86.7%) were white, 19 (6%) African American, and 23 (7.3%) Asian. African Americans were significantly younger than white and Asian women (p = 0.008). Disease presentation, and extent of disease, including antecedent molar histology, median time to persistence, median hCG level at persistence, rate of D&C at persistence, presence of metastatic disease, and FIGO stage and risk score were similar among races. Need for second line chemotherapy (p = 0.023), and median number of regimens (p = 0.035) were greater in Asian women than in other races.Conclusions. Low-risk GTN was more aggressive in Asian women, who were significantly more likely to need second line chemotherapy and a higher number of chemotherapy regimens to achieve complete remission than women of African American and Asian descent. Further studies involving racial differences related to clinical, biological and environmental characteristics are needed. (C) 2015 Published by Elsevier Inc.

Evaluation of microwave-assisted pretreatment of lignocellulosic biomass immersed in alkaline glycerol for fermentable sugars production

A pretreatment with microwave irradiation was applied to enhance enzyme hydrolysis of corn straw and rice husk immersed in water, aqueous glycerol or alkaline glycerol. Native and pretreated solids underwent enzyme hydrolysis using the extract obtained from the fermentation of Myceliophthora heterothallica, comparing its efficiency with that of the commercial cellulose cocktail Celluclast (R). The highest saccharification yields, for both corn straw and rice husk, were attained when biomass was pretreated in alkaline glycerol, method that has not been previously reported in literature. Moreover, FTIR, TG and SEM analysis revealed a more significant modification in the structure of corn straw subjected to this pretreatment.Highest global yields were attained with the crude enzyme extract, which might be the result of its content in a great variety of hydrolytic enzymes, as revealed zymogram analysis. Moreover, its hydrolysis efficiency can be improved by its supplementation with commercial beta-glucosidase.

Spontaneous poisoning by Hovenia dulcis in dairy cattle in Southwest Parana, Brazil

Livestock poisoning by plants is a frequent occurrence which determines severe losses, such as the fall in the milk and meat production, the cost of expensive treatments, the state of immunosuppression, or even the animal's death. Cattle ingest toxic plants only when there is food shortage, when they cannot select what they eat, or when they ingest food for preference, which is the case of Hovenia dulcis fruits, very rich in sucrose. This plant is widely distributed in the southern and southeastern Brazilian regions. In literature, there are some cases of severe human liver injury associated with a long-term of H. dulcis leaf and fruit tea intake, and only one report regarding spontaneous poisoning of goats caused by this plant ingestion. However, its toxic effects associated with spontaneous ingestion by cattle have never been reported. This paper reports the first case of spontaneous poisoning in cattle by H. dulcis, which occurred in a dairy farm in southwest Paraná, Brazil. Three cattle individuals showed anorexia, ruminal atony, severe diarrhea and neurological tournament, head pressing, blindness, ataxia, and circling. The necropsy of the animals was done, and the remaining alterations were restricted to the digestive system and brain. The clinical signs presented by the animals are characteristic of polioencephalomalacia (PEM), caused by changes in the thiamine metabolism. Furthermore, clinical signs, gross, and microscopic lesions as well as the large amount of the plant throughout the digestive segment led to a diagnosis.

Identidades em movimento: a representação feminina e as relações de gênero na obra de Angela Carter

Pós-graduação em Letras - FCLAS

O consumo de laticínios está associado à redução de triglicerídios e alterações na composição corporal de mulheres com sobrepeso e obesidade: um estudo de intervenção de 12 semanas

Pós-graduação em Saúde Coletiva - FMB

O que os homens têm a dizer sobre as mulheres? Os novos posicionamentos de jovens do gênero masculino frente às transformações femininas nas relações afetivas: uma leitura sob a ótica da Psicologia Analítica

Pós-graduação em Educação Sexual - FCLAR

Lymphoepithelial cyst in jugal mucosa

Mouth lymphoepithelial cyst is rare, with few cases reported in literature. The aim of this article is to describe a clinical case, focusing on clinical and diagnostic aspects, treatment and prognosis. The lesion was one year old and had developed as a fibrous nodule in the jugal mucosa of a 71-year-old leucoderma patient. Considering focal inflammatory fibrous hyperplasia, fibroma and mucocele as differential diagnosis, excisional biopsy was carried out. A cystic cavity limited by pseudostratified epithelium without projections into the conjunctive tissue, with lymphoid tissue within, was microscopically identified. Without postoperative adverse events, the one-year clinical followup confirmed the favorable prognosis of this kind of lesion.

A vivência de mulheres em cargos em cargos executivos em grandes empresas: uma análise interseccional das desigualdades de gênero e de Raça

Pós-graduação em Ciências Sociais - FCLAR

Reflexão sobre a atuação de mulheres nas áreas de ciência e tecnologia

This paper proposes an observation that leads to new ways of thinking regarding to women's in science and technology fields, based on previous researches that report this matter. The first detailed work on the participation and achievement of women in Science was "Women in Science" in 1913, written by HJ Mozans, a Catholic priest. According to Schienbinger (2001), this work used to invite women to develop activities in scientific areas and unleash the energies of half population of the planet. It's also important to consider the role of international organs, such as UNESCO, which since the 1990s develops studies, researches and conferences in order to discuss the inclusion of women in activities which involve science and technology. A survey based on data from literature is necessary to make a assessment on this subject in current times.

Participação de mulheres na gestão esportiva: uma revisão sistemática

During the last decades of the XX century occurred several demographic, cultural and social changes that directly affected the inclusion of women in the labor market. However many of them have found and still find barriers to work in various fields of endeavor and in the case of this study, the sports management. The purpose of this study was to assess through a systematic review, the participation of women in sports management, listing the main characteristics, challenges and difficulties. The research consisted of a systematic review of studies that discuss the thematic related to the participation of women in sport management in Brazil, including the Google Scholar database. The key words used and that generated proceeds were woman, sports management and women in sports administration. In the discussion and results has been possible to list the insert forms in a management position, the main ones being: by invitation, conduction or family relationship. The arguments about the limited participation of women in sports management and their encountered barriers are justified because there is a male domain and prejudice, resulting often the career waiver for these women. The profile of the sporting managers has found a predominance of men aged between 30-49 years old. For unavailability of articles, the present study was restricted to use only one database. In short, there is a lacuna in studies on women's participation in the administration or sporting management, with a prevalence of literature review articles. To expand overview on this issue would be important to carry out quantitative studies. It was concluded that the difficulty of women entering in sports management still seems to be a current problem and can only be minimized from a greater attention from the scientific community. It is suggested to carry out further studies that address more deeply the reasons for this disparity, aimed at proposing specific changes to the...

As mulheres não tão silenciosas de Roma: representações do feminino em Plínio, o Jovem (62 a 113 d.C)

Pós-graduação em História - FCLAS

Parameterization of bio-optical models for estimating chlorophyll-a concentration in a tropical eutrophic reservoir

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

As representações do feminino em As brumas de Avalon, de Marion Zimmer Bradley

This present work is a theoretical and qualitative research divided into three chapters that aims to demonstrate how the representations of the female in the book The Mists of Avalon (1982), writing by Marion Zimmer Bradley, dialogues and revises the tradition of cavalry novels on the Arthurian legend, particularly Thomas Malory's Le Morte D'Arthur (1485) which brings the female from the images ideologically constructed of angel and monster. Bradley innovate the Matter of Britain when she created a version of the Arthurian myth following a perspective guided on the female. From the analysis of the history of Bradley's writing as well as the historical context of the development of feminism and the feminist criticism in which she wrote will be sought-point as The Mists of Avalon part of the tradition, but reframes the traditional episodes in order to deconstruct the patriarchal sense and the male images about the feminine