Desenvolvimento e avaliação de uma miniestação ecoeficiente de tratamento de esgoto e reuso de águas, com sistemas registrador queimador, para baixa vazões de biogás e cogeração de energia

Pós-graduação em Engenharia Mecânica - FEG

Estudo comparativo das associações de macroinvertebrados bentônicos e do sedimento dos reservatórios de Chavantes e Salto Grande (rio Paranapanema, SP, PR) e avaliação toxicológica da água e sedimento

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Efeito do selante de fibrina derivado de peçonha de serpente associado a células-tronco mesenquimais na cicatrização de ferida cirúrgica em ratos

Pós-graduação em Doenças Tropicais - FMB

Avaliação da angiogênese em resposta ao tratamento com melatonina no câncer de mama: estudo in vitro e in vivo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Osteogênese sobre titânio com nanotopografia

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Quantificação de poluentes emitidos durante a queima de biomassa florestal em laboratório

Pós-graduação em Engenharia Mecânica - FEG

Estudo de propagação de ondas em planície de inundação para elaboração de plano de ação emergencial de barragens: UHE Três irmãos estudo de caso

Pós-graduação em Engenharia Civil - FEIS

New treatment strategies for Alzheimer's disease: is there a hope?

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, and corresponds to the most common cause of dementia worldwide. Although not fully understood, the pathophysiology of AD is largely represented by the neurotoxic events triggered by the beta-amyloid cascade and by cytoskeletal abnormalities subsequent to the hyperphosphorylation of microtubule-associated Tau protein in neurons. These processes lead respectively to the formation of neuritic plaques and neurofibrillary tangles, which are the pathological hallmarks of the disease. Clinical benefits of the available pharmacological treatment for AD with antidementia drugs (namely cholinesterase inhibitors and memantine) are unquestionable, although limited to a temporary, symptomatic support to cognitive and related functions. Over the past decade, substantial funding and research have been dedicated to the search and development of new pharmaceutical compounds with disease-modifying properties. The rationale of such approach is that by tackling key pathological processes in AD it may be possible to attenuate or even change its natural history. In the present review, we summarize the available evidence on the new therapeutic approaches that target amyloid and Tau pathology in AD, focusing on pharmaceutical compounds undergoing phase 2 and phase 3 randomized controlled trials.

Search for supersymmetry in pp collisions at root s=8 TeV in events with a single lepton, large jet multiplicity, and multiple b jets

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Comparative study for hardwood and softwood forest biomass: Chemical characterization, combustion phases and gas and particulate matter emissions

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Reproductive migration of fish and movement in a series of reservoirs in the Upper Parana River basin, Brazil

AbstractThis study evaluates the effectiveness of two fish passes at two hydropower dams (Canoas I and II) in the Upper Parana basin, which form part of a cascade of three reservoirs. Fish from 12 migratory species (3089 specimens) were captured during their ascending, reproductive migration and were tagged with hydrostatic tags. The recapture data (294 specimens over two consecutive years) showed that there is a strong tendency for the maintenance of ascending migration through reservoirs with fish passes but with differences in migratory activity within the same species. No eggs, larvae or juveniles of these species were found in samples collected over 5 years in the reservoirs above the fish passes. These data suggest that fish passes have contributed to the restoration of the migratory routes of adult fish but that in the absence of suitable spawning or nursery habitats for these species; they probably act as ecological traps and do not contribute to the recruitment of the species.

Deregulation of Annexin-A1 and Galectin-1 Expression in Precancerous Gastric Lesions: Intestinal Metaplasia and Gastric Ulcer

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Real-time monitoring of ozone in air using substrate-integrated hollow waveguide mid-infrared sensors

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Monitoring of hydrogen sulfide via substrate-integrated hollow waveguide mid-infrared sensors in real-time

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aerobic Training Prevents Dexamethasone-Induced Peripheral Insulin Resistance

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)