GnRH/GnIH e seus receptores no sistema olfato-retinal de zebrafish

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Efeito da inibi����o dos receptores canabin��ides CB��� ou CB��� durante o per��odo neonatal sobre o dimorfismo sexual esquel��tico ao longo do desenvolvimento

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

An��lise hormonal, imunolocaliza����o e quantifica����o dos receptores de andr��genos (AR) e estr��genos (ER-�� E ER-��) em ov��rio e ��tero de ratas submetidas a diferentes doses de decanoato de nandrolona: avalia����o nos per��odos p��s-tratamento e p��s-recupera����o

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

O uso das redes sociais online nas intera����es de produtores e receptores de televis��o

This paper discusses the possibility of receiver���s participation in the production of television content mediated by online social networks. Buoyed by media convergence, this research demonstrates how the receiver has been working in online digital media such as TV can take advantage of the specific interaction between the medias to promote the creation of collaborative content, in which the user of social network may interfere the result of the product developed, becoming a new mediatic protagonist. Tool not so used for the production of television that slowly begins to enter the virtual reality, the forging of this new compose process would not only entertain the receiver, but also enrich the language and content television constantly criticized. This study shows the influence of the television medium in which is discussed online, the attitude still shy of the user in content production, and discusses the potential of social networks as a channel of communication between producers and receivers. This work is structured from the definition of social network, in addition to conducting the study what kind of interaction between TV and online social networks is practiced today. Finally, debate whether the potential interaction between TV and social networks is used to its fullest.

Papel dos receptores TLR2 e TLR4 na produ����o de citocinas em pacientes chag��sicos cr��nicos

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

Detec����o imunoistoqu��mica de receptores de estr��geno e progesterona no endom��trio de vacas Nelore (Bos taurus indicus) durante o anestro p��s-parto

Twenty-four postpartum anestrous Nelore purebred cows were used in the study. Anestrous was determined based on the reproductive history which was confirmed in each cow based on plasma progesterone concentration and by transrectal ultrasonography. Endometrial biopsies were collected. The animals were separated into two groups according to maximum follicular diameter- Group 1: follicles <6mm (n=12) and Group 2: follicles >-6mm follicles (n=12). The immunohistochemistry technique was employed to evaluate the presence of estrogen and progesterone receptors in the uterine glandular epithelium and stroma. High counts of positive nuclei and high intensity of immunostain for estrogen and progesterone receptors in the glandular epithelium and stroma were observed in the two groups. However, the immunostain intensity of progesterone receptors in the glandular epithelium was higher in Group 2 compared to Group 1. When glandular epithelium and stroma were compared within each group, the relative number of estrogen receptors in the Group 1 was higher in the glandular epithelium compared to stroma and the immunostain intensity for the progesterone receptor in Group 2 was higher in the glandular epithelium compared to stroma. The results suggest that the mechanisms that control the expression of endomerial receptors in the anestrus are similar to the ones observed during the estrus cycle.

Envolvimento de receptores 5-HT1A no hipocampo ventral na regula����o de comportamentos defensivos relacionados com a ansiedade generalizada e com o p��nico

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

Comportamento materno e c��ncer de bexiga urin��ria: implica����es da modula����o de eixos hormonais e receptores de esteroides na fisiopatologia de les��es neopl��sicas

Coordena����o de Aperfei��oamento de Pessoal de N��vel Superior (CAPES)

Express��o g��nica e prot��ica de receptores Toll-like em c��lulas do sangue perif��rico materno de gesta����es normais e complicadas por prematuridade

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Characterization and evaluation of the impact of feed management on the effluents of Nile tilapia (Oreochromis niloticus) culture

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Efeitos comportamental, cl��nico e analg��sico promovidos pela inje����o epidural preventiva de morfina, xilazina ou clonidina, em equinos

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

Metodologia para avalia����o do desempenho de receptor de GPS de uso agr��cola em condi����o cinem��tica

Activities that use Global Navigation Satellite System (GNSS) are countless and the most used one is the Global Positioning System (GPS) developed by the United States. In precision agriculture there are demands for static and cinematic positioning with distinct levels of accuracy for different applications; nevertheless cinematic performance data are not available as manufacturers of GPS receivers present only static performance information. For this reason it was developed an instrumented vehicle to test a methodology of performance evaluation of GPS receivers in kinematic conditions, which is representative to agricultural operations. A set of instrumentation was composed and used for collecting data under variable speed and rotation direction. Tests were conducted showing that the methodology allows to measure accuracy and precision, but improvements have to be implemented on the instrumentation equipment for long term tests.

Per��odo de m��nima atividade solar: melhora no desempenho do posicionamento relativo

In the relative positioning, even considering that part of the errors due to ionosphere is canceled with the double-difference observations, strong ionospheric effects can occur in maximum solar activity period. However, in minimum solar activity period, the ionospheric effects decrease significantly and therefore an improvement of the relative positioning performance takes place. In this paper we aim at showing that improvement for the scientific and GPS community users. So, have been experiments by using GPS data of two stations of the Brazilian Network for Continuous Monitoring of GPS, forming a baseline of 430 km. The processing were use accomplished with interval of two hours, and only L1 carrier data have been used. The analysis of the obtained results has been carried out from the discrepancies between the "true" coordinates and corresponding ones obtained in the processing. In maximum solar activity period the discrepancy value reached 25 m. on the other hand, in minimum solar activity period, the discrepancy value reached 5,5 m. It is important to emphasize that the majority of the discrepancy values didn't exceed 0,50 m, and in some cases only reached 0,10 m. This shows the increase of application possibilities of the relative positioning using single-frequency GPS receivers in minimum solar activity period.

Comparative study of analytical methods by direct and first-derivative UV spectrophotometry for evaluation of losartan potassium in capsules

O losartano pot��ssico �� um agente anti-hipertensivo n��o pept��dico, que exerce sua a����o por bloqueio espec��fico dos receptores da angiotensina II. Este trabalho prop��s a valida����o e aplica����o de m��todos anal��ticos orientados ao controle de qualidade de losartano pot��ssico 50 mg na forma farmac��utica c��psula, utilizando a espectrofotometria direta e derivada de primeira ordem na regi��o do UV. Baseado nas caracter��sticas espectrofotom��tricas de losartano pot��ssico, um sinal a 205 nm do espectro de ordem zero e um sinal a 234 nm do espectro de primeira derivada foram adequados para a quantifica����o. Os resultados foram usados para comparar essas duas t��cnicas instrumentais. O coeficiente de correla����o entre as respostas e as concentra����es de losartano pot��ssico na faixa de 3,0-7,0 mg L-1 e 6,0-14,0 mg L-1 para espectrofotometria direta e derivada de primeira ordem em solu����o aquosa, respectivamente, foi de (r) of 0,9999 para ambos os casos. Os m��todos foram aplicados para quantifica����o de losartano pot��ssico em c��psulas obtidas de farm��cias de manipula����o locais e demonstraram ser eficientes, f��ceis de aplicar e de baixo custo. Al��m disso, n��o necessitam de reagentes poluentes e requerem equipamentos economicamente vi��veis.

Bases neurofisiol��gicas da depend��ncia do tabaco

A maioria dos estudos pr��-cl��nicos e cl��nicos aponta a nicotina como o principal agente respons��vel pelo desenvolvimento da depend��ncia ao tabaco. Muitos trabalhos t��m demonstrado que as bases neurais da depend��ncia �� nicotina s��o semelhantes ��quelas das outras drogas de abuso. A nicotina induz prefer��ncia condicionada por lugar e auto-administra����o e, portanto, atua como refor��ador positivo, esse efeito parece ser mediado pelo sistema dopamin��rgico mesol��mbico. A nicotina tamb��m induz �� sensibiliza����o comportamental que �� provavelmente resultante de altera����es da express��o g��nica do n��cleo acumbens induzidas pela exposi����o prolongada a essa subst��ncia. A suspens��o do uso de nicotina resulta em s��ndrome de abstin��ncia. As evid��ncias indicam que esses sinais e sintomas sejam mediados por receptores colin��rgicos nicot��nicos centrais e perif��ricos. Outros neurotransmissores, como por exemplo a serotonina e os pept��deos opi��ides, tamb��m podem estar envolvidos na media����o da depend��ncia e s��ndrome de abstin��ncia �� nicotina. A revis��o da literatura mostra a complexidade dos efeitos da nicotina no organismo. A integra����o entre as abordagens comportamental, neuroqu��mica e molecular possibilitar�� a compreens��o dos mecanismos neurais da depend��ncia ao tabaco e fornecer�� as bases para o desenvolvimento racional de agentes terap��uticos que possam ser utilizados para o tratamento da depend��ncia e s��ndrome de abstin��ncia ao tabaco.