Avaliação da proliferação celular e apoptose nas hepatopatias crônicas caninas não neoplásicas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estrutura, ultraestrutura e histoquímica do aparelho digestório do Prochilodus lineatus. Análise da diversidade da microbiota intestinal de Prochilodus lineatus e Pterygoplichthys anisitsi

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Biomarcadores genéticos e bioquímicos para avaliar os efeitos do biodiesel, por meio de bioensaios in vivo e in vitro

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Relação entre o corpo gorduroso e a vitelogênese em fêmeas de Melipona quadrifasciata anthidioides Lep

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação dos efeitos do fipronil (ingrediente ativo do FRONTLINE®) nos ovários de carrapatos Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) e no sangue periférico de roedores

Pós-graduação em Ciências Biológicas (Biologia Celular e Molecular) - IBRC

Infecção experimental em caprinos infectados com Trypanosoma evansi Steel, 1885 (Sarcomastigophora: Trypanosomatidae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Intoxicação cúprica experimental em ovinos: aspectos clínicos e laboratoriais

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Perfis hematológico, hepático, lipídico e lipoprotéico de cães (Canis familiaris) com doença hepática

Pós-graduação em Medicina Veterinária - FMVZ

Indução da diferenciação hepatocítica a partir de células-tronco mesenquimais isoladas da medula óssea e da retina humanas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Falência hepática aguda: caracterização e quantificação dos tipos celulares envolvidos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Eletroforetograma de proteínas de perus (Meleagris gallopavo) vacinadas conta a doença de Newcastle durante o período de postura

Pós-graduação em Medicina Veterinária - FMVZ

Avaliação in vivo e in vitro do potencial citotóxico, genotóxico e mutagênico da água e do sedimento do rio Corumbataí - São Paulo, Brasil

Pós-graduação em Ciências Biológicas (Biologia Celular e Molecular) - IBRC

Histologia hepática e produção em tanques-rede de tilápia-do-nilo masculinizada hormonalmente ou não masculinizada

The aim of this work was to evaluate the performance and the liver structure health of Nile tilapia hormonally masculinized or nonmasculinized, reared in cages with two protein levels. Two groups of Nile tilapia of Thai lineage (total 2,400), with 127 g initial average weight, were distributed in a completely randomized design with four treatments, in a 2x2 factorial arrangement, corresponding to the groups of hormonally masculinized or nonmasculinized fish, and to diet protein level of 28 or 32% of crude protein, with three replicates. After 115 days feeding, there was no interaction between the factors for final weight, weight gain, feed conversion rate, final length and survival. There was no difference between hormonally masculinized and nonmasculinized fish for final weight, weight gain, and survival, which shows the possibility of their production in cages, without the need of hormonal masculinization. Crude protein at 32% in the diet enables a better performance for both groups. Histological changes in the liver - such as increased cell volume, disruption of the cord-like arrangements, and increase of vesicles in the hepatocytes - are found in hormonally masculinized fish, and are more pronounced in fish fed 32% crude protein in the diet.

Efeito da suplementação de vitamina D no desenvolvimento de lesões pré-neoplásicas quimicamente induzidas em ratos Wistar macho

Pós-graduação em Biologia Geral e Aplicada - IBB

Effect of Statins and Aerobic Physical Exercise on Liver Function in Dyslipidemic Rats - Morphometric Study

The present study was carried out to evaluate the effect of statins associated with physical exercise (PE) in liver cells in dyslipidemic rats through cariometry. The animals were divided into six groups: animals subjected to a hypercholesterolemic diet (HD), simvastatin, with (G1) and without (G2) physical exercise (PE); HD submitted (G3) or not (G4) to PE, and commercial food diet (F) with (G5) and without (G6) PE. Histological analysis of the liver was performed by staining the slides with hematoxylin and eosin. The cariometric study included measuring the major and minor diameters of the hepatocytes nuclei. The Shapiro-Wilk test was also performed. To determine the differences among the groups, the Kruskal-Wallis Test with Dunn's post-test were conducted. The significance level was set at 5%. No difference was found in the hepatocytes nuclei between G5 and G6. When these groups were related with G3 and G4, reduced nuclei were observed. There was no difference between G1 and G6. The comparison between G6 and G2 showed that the nuclei in G2 were smaller. No difference was detected between G5 and G1. Changes were observed in the nuclei shape in G2 in comparison to G1. Considering G2 and G3, a decrease in the size of nuclei was observed in G3. On the other hand, G2 showed changes in shape in the comparative analysis with G4. The size and shape of G1 nuclei were larger than G3 as well as changes in shape were observed when compared to G4. G4 showed smaller nuclei than G3. Therefore, F, associated or not with the practice of PE, does not alter the size and shape of the hepatocytes nuclei; HD combined with sedentarism influences changes in the morphometric parameters of hepatocytes; and the association of simvastatin and PE seems to protect the hepatocytes nuclei with regard to HD.