83 resultados para Triggers


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Psicologia do Desenvolvimento e Aprendizagem - FC

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Ciências Cartográficas - FCT

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Pós-graduação em Engenharia Elétrica - FEIS

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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A better understanding of the paracrine and autocrine regulatory loops within the cumulus-oocyte complex (COC) is fundamental for the improvement of in vitro maturation (IVM) outcomes in humans and domestic species. This review presents the most important local regulators identified in the COC to date with special attention to those secreted by the oocyte and acting on cumulus cells, as well as their roles in different processes crucial for the successful maturation of the COC. An autocrine regulatory loop mediated by epidermal growth factor-like (EGF-like) peptides in cumulus cells triggers COC maturation. During COC differentiation, oocyte secreted factors (OSFs), particularly members of the transforming growth factor-beta (TGF beta) and fibroblast growth factor (FGF) families, regulate meiotic resumption, cumulus expansion, cumulus metabolism, apoptosis and steroidogenesis.

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The disaster natural disaster stand as one of the greatest challenges of urban man. Cities are built and modeled as a function of economic and political issues, without respecting environmental characteristics. So it is possible to see through the data of the National Civil Defence large number of disasters occurring in Brazilian cities in the years 2009 to 2011, and in all were reported over 5000 occurrences of natural disasters over the years. The Brazilian public policy failures show up in issues of urban planning where to admit the allocation of people in inappropriate areas. Another issue to be considered is the non-response of the population to civil defense warnings, people often prefer to risk staying in high-risk areas for fear of being robbed while they are away, and end up not serving the notices given by the Civil Defense, increase thus the number of victims when in fact the weather event triggers natural disasters one