Estado, políticas públicas e previdência social no Brasil: uma análise a partir da aposentadoria por tempo de contribuição

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A lógica social da moda: apontamentos para uma teoria crítica da cultura de consumo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Glândula hipofaríngeas na vespa social Polistes versicolor (Olivier): da morfologia às relações com o comportamento

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Políticas públicas e história de formação de professores de ciências: uma análise a partir da teoria social de Habermas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Inclusão escolar e gênero: o ambiente escolar como fator de influência no currículo social e acadêmico dos alunos das séries iniciais do ensino fundamental

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Discurso social, história e política no romance histórico contemporâneo de língua portuguesa: Leminski, Lobo Antunes e Pepetela

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O impacto epidemiológico e social das ações do Programa de Saúde da Família - PSF, na saúde dos usuários em Feira de Santana - Bahia

Pós-graduação em Odontologia Preventiva e Social - FOA

A saúde de jovens mães: desafios para os sitemas de proteção social

Pós-graduação em Serviço Social - FCHS

Impacto social do transplante cardíaco

Pós-graduação em Serviço Social - FCHS

Um dos desafios da questão social: adolescentes em cumprimento de medida sócioeducativa em Araraquara-SP

Pós-graduação em Serviço Social - FCHS

Os caminhos da participação e do controle social na saúde: estudo das realidades do Brasil e Espanha

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise organizacional do partido da social democracia brasileira no estado de São Paulo (1988-2006): a estrutura relacional e o capital político

Pós-graduação em Ciências Sociais - FCLAR

Influence of the dopaminergic system, CREB, and transcription factor-B on cocaine neurotoxicity

Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damage is complex and involves interactions of the drug with several neurotransmitter systems, such as the increase of extracellular levels of dopamine and free radicals, and modulation of transcription factors. The aim of this review was to evaluate the importance of the dopaminergic system and the participation of inflammatory signaling in cocaine neurotoxicity. Our study showed that cocaine activates the transcription factors NF-κB and CREB, which regulate genes involved in cellular death. GBR 12909 (an inhibitor of dopamine reuptake), lidocaine (a local anesthetic), and dopamine did not activate NF-κB in the same way as cocaine. However, the attenuation of NF-κB activity after the pretreatment of the cells with SCH 23390, a D1 receptor antagonist, suggests that the activation of NF-κB by cocaine is, at least partially, due to activation of D1 receptors. NF-κB seems to have a protective role in these cells because its inhibition increased cellular death caused by cocaine. The increase in BDNF (brain-derived neurotrophic factor) mRNA can also be related to the protective role of both CREB and NF-κB transcription factors. An understanding of the mechanisms by which cocaine induces cell death in the brain will contribute to the development of new therapies for drug abusers, which can help to slow down the progress of degenerative processes.

Aplicação de análise de sobrevivência no estudo da imobilidade tônica e do comportamento de reintegração social de perdizes (Rhynchotus rufescens)

Pós-graduação em Genética e Melhoramento Animal - FCAV

Perinatal Periodontal Disease Reduces Social Behavior in Male Offspring

Objective: Our objective was to verify whether prenatal maternal periodontitis is a risk factor for the development of central nervous system disorders in rats. Methods: Periodontitis was induced by placing a ligature around the upper and lower first molars in 9 female Wistar rats (experimental group); 9 rats were left unligated (control group). The maternal general activity in an open field was observed on gestational day (GD) 0, GD 4, and GD 14, and the maternal performance was assessed on the second day after birth. The pups' play behavior was assessed on postnatal day 30. The relative level of reelin was measured in the frontal cortex by real-time PCR analysis. Results: The results showed that, compared with the control group, (1) the general activity in female rats with periodontitis was decreased, (2) the maternal performance of these rats was not modified by periodontitis, (3) the play behavior of pups from dams with periodontitis was decreased, and (4) there were no differences in the frontal cortex reelin levels of pups from dams with periodontitis. Conclusions: We conclude that pre- and postnatal periodontitis induces maternal sickness behavior and reduces the pups' play behavior without interference with frontal cortex reelin expression. Copyright (C) 2012 S. Karger AG, Basel