On the stability of the RuCl2(triphenylphosphine)(2)(amine) complexes: Ligand substituent effects of cyclic and acyclic amines

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Espectalina, cassina e análogos semissintéticos como potenciais candidatos a fármacos para o tratamento da doença de Alzheimer

This paper describes the main steps in the study of Senna spectabilis, as part of our bioprospection studies, with the isolation of spectaline, cassine and other piperidine alkaloids, as well as the preparation of semi-synthetic analogues, and the studies of their pharmacological and toxicological properties, which led to the establishment of two candidate drugs for the treatment of Alzheimer disease.

Síntese de tetra-hidropiridinas por meio de reações multicomponentes

Multicomponent Reactions are defined as reactions between three or more reagents in a single reaction step in the same reaction vial, forming a product that includes the majority of atoms and structural characteristics of the reagents. Thus these reactions save time and energy. One of the ways to improve the yield and reaction time of a multicomponent reaction is to use different catalysts, an example of catalyst that shows great potential and has been studied in recent years is the molecular iodine is known to be a Lewis acid with high catalytic power. The functionalized piperidines, also known as tetrahydropyridines, are alkaloids that have pharmacological potential, this is due to the piperidine ring present in many natural product structures with muscarinic activity, nicotine, analgesic, antipsychotic, anti-proliferative, among others. In this paper we describe studies about on the application of molecular iodine (I2) in the multicomponent reaction between aniline derivatives, benzaldehyde and β-ketoester (methyl acetoacetate) for the synthesis of functionalized piperidines and the synthesis of a corresponding piperidone by acid hydrolysis. Data analysis allowed us to demonstrate the efficacy of molecular iodine in the synthesis of functionalized piperidines, obtaining results with yields 44-87% and short reaction time of 8 to 24 hours, and the efficacy of acid hydrolysis of enamine in the structure of the tetrahydropyridine derivative in a yield of 81%

Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)