Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
21/10/2015
21/10/2015
15/05/2015
|
| Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Processo FAPESP: 03/02176-7 Processo FAPESP: 2013/07600-3 Processo FAPESP: 2010/52327-5 Previously we designed a series of pyridinic anticholinesterasic compounds based on molecular hybridization between tacrine and the natural piperidine alkaloid (-)-3-O-acetylspectaline isolated from Senna spectabilis. Based on the information that the cholinergic system has an important role in the treatment of schizophrenia and depression, we herein report the evaluation of a series of pyridinic compounds in animal models for antipsychotic and antidepressant-like activities. Compound 2 decreased the immobility time of mice in the forced swimming test (5 and 10 mg/kg p.o.) and prevented the climbing behavior induced by apomorphine (10 mg/kg, p.o.), without impairing animals locomotor activity. |
| Formato |
2247-2250 |
| Identificador |
http://www.sciencedirect.com/science/article/pii/S0960894X15001705 Bioorganic & Medicinal Chemistry Letters. Oxford: Pergamon-elsevier Science Ltd, v. 25, n. 10, p. 2247-2250, 2015. 0960-894X http://hdl.handle.net/11449/129122 http://dx.doi.org/10.1016/j.bmcl.2015.02.050 WOS:000353526300043 |
| Idioma(s) |
eng |
| Publicador |
Elsevier B.V. |
| Relação |
Bioorganic & Medicinal Chemistry Letters |
| Direitos |
closedAccess |
| Palavras-Chave | #Pyridinic alkaloid analogs #Antidepressant-like activity #Antipsychotic #Apomorphine-induced climbing #Forced swimming test |
| Tipo |
info:eu-repo/semantics/article |
