Análise de pedigree e estimativas de parâmetros genéticos para características de importância econômica em bovinos Tabapuã

Pós-graduação em Genética e Melhoramento Animal - FCAV

A systematic review and meta-analysis of cohort studies of echocardiographic findings in OSA children after adenotonsilectomy

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A synthesis of captopril through a Baylis-Hillman reaction

A synthesis of the antihipertensive amide 1, named captopril, is described. The strategy is based on a Baylis-Hillman reaction between N-acryloylproline and formaldehyde. Subsequential diastereoselective hydrogenation step and functional group interconversion provided captopril in good overall yield.

DEVELOPMENT OF AN ALGORITHM TO ANALYZE CARTOGRAPHIC FEATURES EXTRACTION METHODS IN DIGITAL IMAGES

The algorithm creates a buffer area around the cartographic features of interest in one of the images and compare it with the other one. During the comparison, the algorithm calculates the number of equals and different points and uses it to calculate the statistical values of the analysis. One calculated statistical value is the correctness, which shows the user the percentage of points that were correctly extracted. Another one is the completeness that shows the percentage of points that really belong to the interest feature. And the third value shows the idea of quality obtained by the extraction method, since that in order to calculate the quality the algorithm uses the correctness and completeness previously calculated. All the performed tests using this algorithm were possible to use the statistical values calculated to represent quantitatively the quality obtained by the extraction method executed. So, it is possible to say that the developed algorithm can be used to analyze extraction methods of cartographic features of interest, since that the results obtained were promising.

Revisitando a dicotomia fala/escrita

This work has by main objective revisit the dichotomy speech/writing from the perspective of scholars in the field of linguistics in relation to the communicative and interactional aspects of language. The research is based on the study of traditional dichotomies that classically distinguish between the oral form and the written form of the language. It is noted here the importance of the study of communication and interaction of individuals, as language being the main aspect responsible for the organization of society, and, of course, also being indispensable for the development of human being. This study shows that the distinctive peculiarities between speech and writing are not of the characteristics of a particular procedure, but differences that are necessary due to the specific moment of creation of an utterance or text, because both the oral and the mode writing may have traces of formality/informality; completeness/incompleteness, among other things. In other words, there is not a distinctive feature that is present only in speech or writing. Thus, this research shows that, by the numberless technological advances, the communication between people has gone through changes and crossed barriers. Therefore, it is clear that with the collaboration of the media, the old dichotomies recommended for speech and writing are being overcome and can no longer be treated strictly to any of the modalities

O conceito de Técnica da Natureza na Crítica da Faculdade do Juízo de Kant

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

On the Bhabha scattering for z=2 Lifshitz QED

In this paper, we compute and discuss the differential cross-section of the Bhabha scattering in the framework of the z = 2 Lifshitz quantum electrodynamics (QED). We start by constructing the classical solutions for the fermionic fields, in particular the completeness relations, and also derive the theory's propagators. Afterwards, we compute the photon exchange and pair annihilation contributions for the Bhabha's process, and upon achieving the results we establish the magnitude of the theory's free parameter by looking for small deviations of the QED tree results.

De novo transcriptome assembly for a non-model species, the blood-sucking bug Triatoma brasiliensis, a vector of Chagas disease

High throughput sequencing (HTS) provides new research opportunities for work on non-model organisms, such as differential expression studies between populations exposed to different environmental conditions. However, such transcriptomic studies first require the production of a reference assembly. The choice of sampling procedure, sequencing strategy and assembly workflow is crucial. To develop a reliable reference transcriptome for Triatoma brasiliensis, the major Chagas disease vector in Northeastern Brazil, different de novo assembly protocols were generated using various datasets and software. Both 454 and Illumina sequencing technologies were applied on RNA extracted from antennae and mouthparts from single or pooled individuals. The 454 library yielded 278 Mb. Fifteen Illumina libraries were constructed and yielded nearly 360 million RNA-seq single reads and 46 million RNA-seq paired-end reads for nearly 45 Gb. For the 454 reads, we used three assemblers, Newbler, CAP3 and/or MIRA and for the Illumina reads, the Trinity assembler. Ten assembly workflows were compared using these programs separately or in combination. To compare the assemblies obtained, quantitative and qualitative criteria were used, including contig length, N50, contig number and the percentage of chimeric contigs. Completeness of the assemblies was estimated using the CEGMA pipeline. The best assembly (57,657 contigs, completeness of 80 %, < 1 % chimeric contigs) was a hybrid assembly leading to recommend the use of (1) a single individual with large representation of biological tissues, (2) merging both long reads and short paired-end Illumina reads, (3) several assemblers in order to combine the specific advantages of each.

Comparing de novo and reference-based transcriptome assembly strategies by applying them to the blood-sucking bug Rhodnius prolixus

High Throughput Sequencing capabilities have made the process of assembling a transcriptome easier, whether or not there is a reference genome. But the quality of a transcriptome assembly must be good enough to capture the most comprehensive catalog of transcripts and their variations, and to carry out further experiments on transcriptomics. There is currently no consensus on which of the many sequencing technologies and assembly tools are the most effective. Many non-model organisms lack a reference genome to guide the transcriptome assembly. One question, therefore, is whether or not a reference-based genome assembly gives better results than de novo assembly. The blood-sucking insect Rhodnius prolixus-a vector for Chagas disease-has a reference genome. It is therefore a good model on which to compare reference-based and de novo transcriptome assemblies. In this study, we compared de novo and reference-based genome assembly strategies using three datasets (454, Illumina, 454 combined with Illumina) and various assembly software. We developed criteria to compare the resulting assemblies: the size distribution and number of transcripts, the proportion of potentially chimeric transcripts, how complete the assembly was (completeness evaluated both through CEGMA software and R. prolixus proteome fraction retrieved). Moreover, we looked for the presence of two chemosensory gene families (Odorant-Binding Proteins and Chemosensory Proteins) to validate the assembly quality. The reference-based assemblies after genome annotation were clearly better than those generated using de novo strategies alone. Reference-based strategies revealed new transcripts, including new isoforms unpredicted by automatic genome annotation. However, a combination of both de novo and reference-based strategies gave the best result, and allowed us to assemble fragmented transcripts.

Projeto pedagógico e estrutura curricular de um curso de odontologia: análise crítica fundamentada na percepção acadêmica

Considering that the current pedagogical project for the Dentistry course at FOA-Unesp was structured in 2001, a year before the national resolution that introduced the new curricular guidelines for the dental field, the aim of this study was to analyze critically this document and assess the academic perception of the pedagogical project, as well as the current curricular structure. A previously tested and validated semi-structured questionnaire was used to obtain the needed information, and a documentary analysis was conducted. The questionnaire was drafted based on data from the National Curricular Guidelines (DCN) and Unified Health System (SUS) guidelines. The sample consisted of almost all the graduating students of 2007 (n = 61). Of these, 95% had no knowledge of the pedagogical project for the undergraduate course; 53% found the integration between the disciplines offered by the course insufficient; 66% pointed out that there was duplication of the revised contents; 41% said that the interdisciplinary relation was unsatisfactory, and 67.2% said they preferred the modular system of teaching. Furthermore, 55.7% of the students said that that the course does not fully cover the principles of completeness and resolution of actions, and 37.7% pointed out that clinical care was not humanized. As for the competence and skills needed to exercise the profession, the students admitted feeling secure about carrying out preventivecurative clinical actions, and feeling insecure about developing broad ranging actions, like managing and planning. Analysis of the documents showed a certain disagreement in the organization of the pedagogical project and the curricular structure, when confronted with the course of action set down by the National Curricular Guidelines. The data prove the urgent need to restructure the FOA-Unesp curriculum and confirm the importance of a continuous evaluation in higher education.

Redes de atenção à saúde para gestantes usuárias de álcool e/ou outras drogas

Pós-graduação em Saúde Coletiva - FMB

A neighbourhood semantic for the Logic TK

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Aplicação de técnicas de processamento e análise de imagens para detecção de edificações e vegetação a partir de dados LiDAR

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)