A synthesis of captopril through a Baylis-Hillman reaction
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
18/03/2015
18/03/2015
01/01/2003
|
| Resumo |
A synthesis of the antihipertensive amide 1, named captopril, is described. The strategy is based on a Baylis-Hillman reaction between N-acryloylproline and formaldehyde. Subsequential diastereoselective hydrogenation step and functional group interconversion provided captopril in good overall yield. |
| Formato |
1141-1146 |
| Identificador |
http://dx.doi.org/10.1081/SCC-120017189 Synthetic Communications. New York: Marcel Dekker Inc, v. 33, n. 7, p. 1141-1146, 2003. 0039-7911 http://hdl.handle.net/11449/116965 10.1081/SCC-120017189 WOS:000182804200011 |
| Idioma(s) |
eng |
| Publicador |
Marcel Dekker Inc |
| Relação |
Synthetic Communications |
| Direitos |
closedAccess |
| Tipo |
info:eu-repo/semantics/article |
