Soluções quase periódicas para equações diferenciais funcionais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Diretrizes de conduta e tratamento de síndromes febris periódicas associadas à criopirina (Criopirinopatias–CAPS)

To establish guidelines based on cientific evidences for the management of cryopyrin associated periodic syndromes. The Guideline was prepared from 4 clinical questions that were structured through Pico (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 1215 articles were retrieved and evaluated by title and abstract; from these, 42 articles were selected to support the recommendations. 1. The diagnosis of Caps is based on clinical history and clinical manifestations, and later confirmed by genetic study. Caps may manifest itself in three phenotypes: FCAS (mild form), MWS (intermediate form) and Cinca (severe form). Neurological, ophthalmic, otorhinolaryngological and radiological assessments may be highly valuable in distinguishing between syndromes; 2. The genetic diagnosis with NLRP3 gene analysis must be conducted in suspected cases of Caps, i.e., individuals presenting before 20 years of age, recurrent episodes of inflammation expressed by a mild fever and urticaria; 3. Laboratory abnormalities include leukocytosis and elevated serum levels of inflammatory proteins; 4. Targeted therapies directed against interleukin-1 lead to rapid remission of symptoms in most patients. However, there are important limitations on the long-term safety. None of the three anti-IL-1β inhibitors prevents progression of bone lesions.

Diretrizes de conduta e tratamento de síndromes febris periódicas: síndrome de febre periódica, estomatite aftosa, faringite e adenite

To establish guidelines based on scientific evidence for the management of periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 806 articles were retrieved and evaluated by title and abstract; from these, 32 articles were selected to support the recommendations. 1. PFAPA is a diagnosis of exclusion established on clinical grounds, and one must suspect of this problem in children with recurrent and periodic febrile episodes of unknown origin, or with recurrent tonsillitis interspersed with asymptomatic periods, especially in children in good general condition and with preservation of weight and height development; 2. Laboratory findings are nonspecific. Additional tests do not reveal pathognomonic changes; 3. The evidence supporting an indication for surgical treatment (tonsillectomy with or without adenoidectomy), is based on two non-blinded randomized clinical trials with small numbers of patients; 4. The use of prednisone at the onset of fever in patients with PFAPA proved to be an effective strategy. There is still need for more qualified evidence to support its use in patients with PFAPA; 5. Despite promising results obtained in studies with IL-1ß inhibitors, such studies are limited to a few case reports.

Estabilidade de pontos de equilíbrio e existência de soluções periódicas em alguns modelos bidimensionais

Pós-graduação em Matemática Universitária - IGCE

A pesquisa em televisão digital no Brasil: apontamento sobre o levantamento bibliográfico realizado de 1995-2008 sobre o assunto

In Brazil, the discussion about thereplacement of analog television signals to digitaland its impact on society, in media companies andgovernment began in the 90s. Embryonic steps towardsdigitalisation of the television signal ground were thegovernment of Fernando Collor de Mello (1990-1992),with advances during the government of FernandoHenrique Cardoso (1994-2001) and in the governmentof Luiz Inacio Lula da Silva (2002). The academy startsthe discussion in 1996. This article aims to bring to lightthe results obtained from the survey Digital television:a historical perspective , which received the supportof CNPq for funding of two scholarships for scientifi cinitiation between August 2008 and July 2009. Theproject sought to identify what has been published onthe subject in the fi eld of Social Sciences and from threemacrodescritores (information management, publicpolicy and value chain), providing the li ing of a virtualcollection Zotero bibliographic innovative platform.The mapping serves to show the growing interest anddevelopment of research in the country during theperiod - when the number jumped to three works inthe fi rst seven years (1995-2001) to 198 in the last sevenyears (2002-2008). The research sought to identify themajor authors and works related to digital televisionand published in the country. The survey took intoaccount books, articles published in books, journals,Annals of Compós and Intercom, and dissertations andtheses. Data and refl ections on the survey are containedin this communication.