344 resultados para Medicamentos (Controle de qualidade)
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The purpose of this work is to provide quality control requirements and security in dental x-rays in order to obtain good quality image which allows the correct diagnosis, which reduces the dose to the patient, mainly due to the repetition of tests, and decreasing cost. The requirements apply to related activities to quality control and procedures using ionizing radiation for diagnostic imaging in dentistry by evaluating a minimum set of parameters to be tested or verified. Quality control follows the Ordinance No. 453 of the Ministry of Health of 06.01.1998, SS Resolution No. 625 of 12.14.1994 and Resolution No. 64 of the Health Surveillance Center – Department of Health of Sao Paulo and National Health Surveillance Agency – Ministry of Health of Brazil. This study was conducted in the city of Marilia, Sao Paulo, along with the Company P&R Consulting and Medical Physics, in a dental clinic of the University UNIMAR in the x-ray equipment used on that site. The physical parameters of the device were tested with the aid of ionization chambers to measure rates of radiation, electrometer to measure rates of time, kV and doses, radiographic films and positioning devices. Finally, this work demonstrates the need and importance of quality control, which one ensures the proper use of x-ray machines, maintaining efficiency and at the same time it reduces the risks to the patient, to the dentist and to the general public
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Befor the vast economical growth and wild scientific and technological development, the companies are demanding, more and more qualification and acting of the services rendered by their employees. Like this, tasks are restricted the they be done with excellence, because the companies are always controlling the worker's development. They are several the tools used by the companies, as acting indexes to control the course of the worker's activities or certain section, integrations for new employees with the objective to present the line of work of the company so that the new employee is framed in these patterns, trainings offered for the employees to carry out their services with quality and compromising, evaluations of year end in order to test the worker's knowledge and to demand better results, finally, the companies hope the employee integrates normativamente into the reality of the company, in way to contribute for the atingimento of the organizational strategies, always collecting for this to obtain the best results and contribute to the growth of the company. This way, that research will present a tool of control of the total quality applied in a company in Rio Clearing's city and that it is managed by an educador. They will be verified the objectives that the company has in relationship a this control, the worker's subjectivity as participant subject of the tool of control of the System of Administration of the Quality and the worker's different glances before these aspects throught an interview.
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The progress in radiology is related with the development of new systems of image formation with the lesser dose in the pacient. The improve of the dose in the pacient, without compromising the quality of the image, is one of the responsibilities of a medical physicist in a sector of diagnosis for image. This research has as objective to evaluate the conditions of use of an equipment of x-rays, from tests of quality control. The results gotten in this work have been part of data of an Effective Program of Quality Control (PECQ) of the sector of diagnosis for image of the Hospital das Clínicas da Faculdade de Medicina de Botucatu - UNESP (HCFMB-UNESP)
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Along with the advance of technology, in terms of the expansion of medical exams that uses the ionizing radiation for diagnosis, there is also the concern about quality control for maintaining quality in radiographic imaging and for delivering low dose to the patient. Based on the Federal Order 453 of the Secretariat of Health Surveillance, which takes account of the practical and justification of individual medical exposures, the optimization of radiological protection, limitation of individual dose, and the prevention of accidents, were done through this paper radiodiagnostic tests on medical equipment in order to accept it or not, according to SVS-453. Along with the help and support of P&R Consulting and Medical Physics Marilia, SP, were made Quality Control and Radiometric Control in equipment from various cities across the state of São Paulo. The equipment discussed in this work is classified as conventional X-ray. According to the Federal Order SVS-453, the quality control in the program of quality assurance should include the following minimum set of constancy tests, with following minimum frequency: biennial tests for representative values of dose given to the patients of radiography and CT performed in the service; annual tests for accuracy of the indicator tube voltage (kVp), accuracy of exposure time, half-value layer, aligning the central axis of the beam of x-ray tube, performance (mGy / mA.min.m²), linearity of the rate of kerma on air with the mAs, reproducibility of the kerma on air rates, reproducibility of the automatic exposure, focal spot size, integrity of accessories and clothing for individual protection; semiannually for collimation system accuracy; weekly for temperature processing system and sensitometry processing system. For the room Radiometric Survey it was done a sketch...(Complete abstract click electronic access below)
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This paper considers a study of the anatomical features of the cardiac system and a three-dimensional model of the different tunics that comprise the heart wall, for processing and quality control of radiological images. The structures are built by the layer overlapping method, where a layer can be understood as a slice of the three-dimensional object. The pericardium, myocardium and endocardium were represented with three-dimensional cylinders and hexagons. The spatial arrangement of the cardiac system is determined by an background image of a real model, which values are defined according to the shape of the region and on the anatomical patients characteristics. The results are significant, considering the anatomical structures details, as well as the representation of the thicknesses of the regions of the heart wall. The validation of the anatomical model was accomplished through comparisons with dimensions obtained from a real model and allows verifying that the model is appropriate. The degree of representation will allow the verification of the influence of radiological parameters, morphometric peculiarities and stage of the diseases on the quality of the images, as well as on the performance of the Computer-Aided Diagnosis (CAD).
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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ANVISA (National Health Surveillance Agency) has published in recent years, laws that regulate the stages of the control of plants derivatives, including tests of macro and microscopic botanical identification, phytochemical determination, tests of authenticity and purity, microbiological testing, among other parameters. All the analytical procedures of plant drugs control required by law must be based on the Brazilian Pharmacopoeia, other Pharmacopoeias recognized by ANVISA or quality control guides of plant species published by the World Health Organization (WHO). This study aimed to evaluate some pharmacognostic, phytochemical screening and microbiological control of plant species of the Brazilian cerrado, which have indicated ethnopharmacological: Byrsonima intermedia (Bi), Bauhinia holophylla (Bh) and Myrcia bella (Mb). In addition, certain parameters were determined for obtaining extracts from plants sprayed and dried. These data are important to obtain new scientific information from Brazilian plants with therapeutic potential.
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Vitamin C is vulnerable to oxidative degradation and then the aim of this study was conducting a literature review about quality control of vitamin C in finished products. The conclusion is determined multiple emulsions and products which contain encapsulant materials are able to protect it from oxidation ensuring its efficacy.
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Pós-graduação em Agronomia (Ciência do Solo) - FCAV
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Pós-graduação em Ciências Farmacêuticas - FCFAR
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Validation of analytical methodology for quantification of cefazolin sodium by liquid chromatography
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A reversed-phase high performance liquid chromatography method was validated for the determination of cefazolin sodium in lyophilized powder for solution for injection to be applied for quality control in pharmaceutical industry. The liquid chromatography method was conducted on a Zorbax Eclipse Plus C18 column (250 x 4.6 mm, 5 μm), maintained at room temperature. The mobile phase consisted of purified water: acetonitrile (60: 40 v/v), adjusted to pH 8 with triethylamine. The flow rate was of 0.5 mL min-1 and effluents were monitored at 270 nm. The retention time for cefazolin sodium was 3.6 min. The method proved to be linear (r2 =0.9999) over the concentration range of 30-80 µg mL-1. The selectivity of the method was proven through degradation studies. The method demonstrated satisfactory results for precision, accuracy, limits of detection and quantitation. The robustness of this method was evaluated using the Plackett–Burman fractional factorial experimental design with a matrix of 15 experiments and the statistical treatment proposed by Youden and Steiner. Finally, the proposed method could be also an advantageous option for the analysis of cefazolin sodium, contributing to improve the quality control and to assure the therapeutic efficacy
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It is known that a high microbial count can compromise the stability of medicines, thus reducing their therapeutic efficacy. This work tried to demonstrate that the microbial contamination can be directly related to the inadequate handling of the medicines stored in homes, making it possible to draw strategies to reduce the possible risks of medical therapy offering correct information and advising. The objective of this work was to evaluate the quality of the medicines containing paracetamol found in the residences of Américo Brasiliense-SP, using the microbial analysis of non-sterile method described in the Brazilian Pharmacopoeia (1988). The medicine samples (30 samples) were obtained directly from the interviewed local residents, who had received new medicine bottles of the same product. An analysis of viable microorganisms (bacteria and fungus) was carried out to identify pathogens found in the collected samples. Although 90% of the analyzed samples have shown some microbial contamination, the results indicated the absence of pathogenic microorganisms, and the total count of viable microorganisms was below the maximum value for non-sterile (104 UFC/g or mL). It was also verified that the local residents stored the medicines in appropriate places, according to the orientations received when they bought the medicines in pharmacies and drugstores, showing the importance of information for the correct use and conservation of pharmaceuticals.
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Pós-graduação em Química - IQ