Perfil clonal e fatores de patogenicidade de Staphylococcus spp. no prognóstico das peritonites em diálise peritoneal

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comunidades mediadas pela internet: fatores de sucesso e modelo de ciclo de vida

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Regulação da expressão dos receptores de fatores de crescimento fibroblásticos 3c e 4 (FGFR-3c e FGFR-4) em folículos antrais bovinos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Dimensões de competitividade para a empresa Brasileira: informação e conhecimento, qualidade, tecnologia e meio ambiente

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Expressão dos fatores de regulação miogênica em cultura de mioblastos submetidos ao TNF-α/IFN-γ

A insuficiência cardíaca (IC) está associada a miopatia dos músculos esqueléticos dos membros, com perda da massa muscular, diminuição na proporção das fibras do tipo I (contração lenta) e aumento na proporção das fibras do tipo II (contração rápida). É provável que alterações na expressão de fatores de transcrição pertencentes à família “basic helix-loop-helix” (bHLH), da qual fazem parte a MyoD, Miogenina, Myf5 e o MRF-4, conhecidos como fatores de regulação miogênica (MRFs), sejam responsáveis pelas mudanças nos tipos de fibras. Enquanto que a Miogenina é expressa em níveis superiores aos da MyoD em músculos lentos, o oposto é verdadeiro para músculos rápidos. Similarmente, a MyoD está associada com a expressão das isoformas de miosina de cadeia pesada rápidas dos tipos IIX e IIB. Estudos in vitro, demonstraram que o TNF-α inibe a expressão de MyoD e miogenina diminuindo a atividade de genes músculo específicos. A ação do TNF-α diminuindo a expressão da MyoD mostra-se mais acentuada quando em associação com o IFN-γ, no entanto, há poucas informações na literatura a respeito do papel desta associação na expressão dos fatores de regulação miogênica, in vitro. Avaliar a expressão dos fatores de regulação miogênica, MyoD, miogenina, Myf5, e MRF-4 em cultura de mioblastos C2C12 submetidos ao TNF-α/IFN-γ. Nossos resultados mostraram um aumentou na expressão dos gene MyoD, Myf5 e miogenina sob tratamento com IFN-γ quando comparado aos grupos controle e TNF-α/IFN-γ. A expressão gênica do MRF-4 na cultura de células não foi detectada em nenhum dos grupos analisados. O GAPDH foi utilizado para normalizar os valores de expressão dos outros genes analisados. O presente estudo demonstrou que o IFN-γ exógeno administrado à culturas de mioblastos... (Resumo completo, clicar acesso eletrônico abaixo)

Fatores facilitadores e restritivos no processo de gestão de franquias sob o ponto de vista do franqueado: um estudo multicasos no setor de alimentação

The present study sought to identify which are the facilitators and restrictive in the creation and management of franchises from the point of view of process factors franchisees. For this, we first proposed to critically analyze its creation and management.The specific objectives of this work are: a) to understand in the light of the theory , the basic requirements for creating franchises b ) identify, from the literature review , facilitators and restrictive factors in the process of franchise management , c) develop a survey tool to critically analyze the processes of creating and managing a franchise from the point of view of the franchisee , and d ) to review the process of creating and managing franchises , from the perspective of four franchised food services in the municipalities of Ribeirão Preto and Sao Jose do Rio Preto - SP . A descriptive qualitative work, which found the most important features about the franchises, through a study of 4 franchises in the food industry of São Paulo was performed. To complete the survey was conducted a semi-structured interview, containing questions regarding the main elements of a business: creating, planning, organization, direction and control. It was found that franchising is a business model with controversies. There are people who deal well with the system and that through him realize dreams such as owning their own business. Others need to think many times before embarking in business since the entrepreneurship factor can be so intense that it hinders the acceptance of norms and duties to the system. This causes some factors such as communication, measurement of outcomes, implementation plan and among others are considered restrictive or facilitators in the process of strategy management of franchises

Avaliação de funcionamento das bombas hidráulicas do sistema de tratamento de efluentes da Empresa Parker Hannifin

On the field of the projects of hydraulic systems exists a lot of worries when we talk about the calculate of hydraulic pumps. In this case some facts must be considerate: length of tubes, fluid characteristics, height gauge, temperature, pressure, characteristics of tubes, flow required and others. For that mathematic calculates must be developed with the objective to optimize hydraulic pumps and agree to find an ideal machine (that don't requires more energy than necessary or less energy than it requires; that is the more critical case, cause exists the risk that the fluid pumped do not agree to become in your destiny). The wrong calculate of this machine can super-size its, bringing an excessive energy consumption. Actually it's an important subject because we are in the age of lack of energy what turn it more expensive. So the correct sizing of a hydraulic pump is connected with the fact that you have to uses the enough energy resources avoiding waste. The calculate of ideal pump in the pumping system is studied during years and a lot of specialists in this subject develop equations and theories to calculate its. Some researches study about this subject and all of them become to the same conclusion: to find the ideal pump we have to know the characteristics of fluid (cinematic viscosity), the required flow , overall yield (overall of motor x overall of pump) the high gauge or discharge pressure and the loss of repression. The pressure drop can be calculated with different theories: using Hazen-Williams, Darcy e Weisbach or Chézy (1775 - that starts the researches to calculate the pressure drop). Although the most used theory and what is most near to reality is the Darcy's equation. So, in this job the Darcy's equation were choice to calculate the drop pressure that consider what kind of flow we are studying: laminar or turbulent. The determination of the best pump to be used in the ... ( complete abstract click eletronic access below)

Avaliação da produtividade no trabalho organizado em turnos em uma empresa vidreira

Work organized in shifts, either for technological, social or economic imposition, allows the best use of means of production, increasing the overall productivity of the enterprises. At the same time, this type of work harms the individual productive capacity of workers, particularly those involved in the night shift. The objective of this work was to assess the behaviour of production in a continuous line and subjected to work organized in shifts. Through the statistical method of analysis of variance, Spearman's test and Tukey's method, was analysed the distribution of the productivity index measured in three fixed shifts of work in a glass company. The productivity index, provided by the integrated management system of the company, refers to the ratio of actual productivity to total productivity. The statistical analysis shows that factors of production, such as allocation of workers, do not interfere with productivity, showing an unexpected pattern, where the average productivity for the three shifts are close and the correlation between the number of workers on the line and productivity is low. The conditions of production had an adverse work environment with exposure to noise, heat, vaporized mist of lubricating oil and risk of accidents. The findings show that the calculation of productivity in use is limited and its use in company’s production control may produce distortions. It is proposed to examine alternative calculations methods that consider the overall productivity

Análise quantitativa de demanda em uma empresa siderúrgica

Companies, in general, operate due to the work of its subsystems and this is possible thanks to operational planning that tries to promote the best way to integrate them without giving up the mission, vision and values of the company. The main purpose of a business is to serve customers, but to be successful must take into account other factors such as survival, profitability, growth and operational standpoint to use their resources effectively. The use of tools to support the process of analysis of management decision-making is gaining importance in the context of competitiveness in the world market. The objective of this paper is to present a simulation of the process of forecasting demand to obtain optimal results for a steel company, compare the actual results with order entry and assess the magnitude of the error

Estudo da implementação do Warehouse Management System em uma empresa produtora de embreagens

In the supply chain management there are several risk factors that must be mitigated to increase the flow of production and as a possible solution the literature cites the implementation of a warehouse management system, but this subject is few explored. This thesis has as main objective the study of the implementation of a warehouse management system in a company from the automotive sector that produces clutches. As results, are shown data of the characterization of items; as well as data and comparisons between disruptions in production reports due to lack of material before and after the implementation of WMS and is presented the result of a questionnaire applied to the involved on the implementation of the system, the results were associated with the risk factors on the implementation of the system studied on the literature review, and enumeration of the results that are not associated with any factors previously studied. And finally, the study is concluded and are recommended future studies related to the theme

Uma Experiência de implantação do método da corrente crítica no gerenciamento de portfólio de projetos de uma empresa tecnológica

TFor companies to remain competitive should seek investment in the project management through new tools. The method Critical Chain has been considered an innovative way to manage projects, to promote change and give great results. However, there are still some questions to be answered and there are few papers reporting on the implementation of CCPM method in real environment of multiple projects. This work analyze the deployment process of Critical Chain at a company in the technology sector, in order to check the risk factors, advantages and difficulties in that process. Showing not only the likely benefits, but also the possible difficulties, mainly cultural and behavioral, inherent in all business transformation processes in order to support the implementation of all theoretical architecture for corporate reality

O papel dos fatores ambientais e espaciais sobre a fauna de Ephemeroptera (insecta) em riachos de mata atlântica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fatores sócio-político-culturais na formação do professor de matemática: análise em dois contextos de formação

Pós-graduação em Educação Matemática - IGCE

Fatores microbiológicos e imunológicos envolvidos no desenvolvimento da cárie precoce da infância

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência dos fatores organizacionais no sucesso de projetos no setor automotivo

Pós-graduação em Engenharia de Produção - FEB