Desenvolvimento de sistema para gerenciamento de dados de pesquisa

Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

Fenologia remota: uso de imagens digitais no acompanhamento fenológico de plantas em uma área de cerrado sensu stricto, no município de Itirapina, São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O léxico da apicultura e da melinponicultura no Brasil: limites e flexibilidade para sua fixação em um dicionário terminológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Traços de tradução em artigos de anestesiologia: uma comparação entre os resultados de um corpus paralelo e de um corpus comparável

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ineraction Model Between HRSV G-Protein and Flavonoids

Background: Acute respiratory infections (ARI) are the leading cause of infant mortality in the world, and human respiratory syncytial virus (HRSV) is one of the main agents of ARI. One of the key targets of the adaptive host immune response is the RSV G-protein, which is responsible for attachment to the host cell. There is evidence that compounds such as flavonoids can inhibit viral infection in vitro. With this in mind, the main purpose of this study was to determine, using computational tools, the potential sites for interactions between G-protein and flavonoids. Results: Our study allowed the recognition of an hRSV G-protein model, as well as a model of the interaction with flavonoids. These models were composed, mainly, of -helix and random coil proteins. The docking process showed that molecular interactions are likely to occur. The flavonoid kaempferol-3-O-α-L-arabinopyranosil-(2 → 1)-α-L-apiofuranoside-7-O-α-L-rhamnopyranoside was selected as a candidate inhibitor. The main forces of the interaction were hydrophobic, hydrogen and electrostatic. Conclusions: The model of G-protein is consistent with literature expectations, since it was mostly composed of random coils (highly glycosylated sites) and -helices (lipid regions), which are common in transmembrane proteins. The docking analysis showed that flavonoids interact with G-protein in an important ectodomain region, addressing experimental studies to these sites. The determination of the G-protein structure is of great importance to elucidate the mechanism of viral infectivity, and the results obtained in this study will allow us to propose mechanisms of cellular recognition and to coordinate further experimental studies in order to discover effective inhibitors of attachment proteins.

Modelação de redes de distribuição de energia elétrica com carregamento não linear, incluindo elementos de regulação e compensação

Pós-graduação em Engenharia Elétrica - FEIS

Otimização da operação de sistemas de distribuição radiais usando um algoritmo genético especializado

Pós-graduação em Engenharia Elétrica - FEIS

Lean construction como estratégia para melhorias em canteiros de obras: uma revisão sistemática na literatura nacional

Pós-graduação em Engenharia de Produção - FEB

Sinais de vibração no monitoramento do processo de retificação plana de cerâmicas avançadas

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Associações entre borboletas frugívoras em áreas de floresta com diferentes históricos de perturbação antrópica

Pós-graduação em Ecologia e Biodiversidade - IBRC

Arborização de vias urbanas: potencial de sombreamento das espécies

Pós-graduação em Arquitetura e Urbanismo - FAAC

Structural studies of prephenate dehydratase from Mycobacterium tuberculosis H37Rv by SAXS, ultracentrifugation, and computational analysis

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Applying GIS tools for analysing urban thermal environment

A methodology for analyzing the solar access and its influence on both air temperature and thermal comfort of the urban environment was here developed by applying the potentiality of GIS tools. Urban canyons in a specific area of a Brazilian medium sized city were studied. First, a computational algorithm was applied in order to allow the determination of sky view factors (SVF) and sun-paths in urban canyons. Then, air temperatures in 40 measurement points were collected within the study area. Solar radiation values of these canyons were determined and subsequently stored in a GIS database. The creation of thermal maps for the whole neighbourhood was possible due to a statistical treatment of the data, by promoting the interpolation of values. All data could then be spatially cross-examined. In addition, thermal comfort maps for summer and winter periods were generated. The methodology allowed the identification of thermal tendencies within the neighbourhood, what can be useful in the conception of guidelines for urban planning purposes.