423 resultados para capacidade antioxidante
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Câncer é o nome dado a um conjunto de mais de 100 doenças que têm em comum o crescimento desordenado (maligno) de células que invadem tecidos e órgãos, podendo espalhar-se (metástase) para outras regiões do corpo. Dividindo-se rapidamente, estas células tendem a ser muito agressivas e incontroláveis, determinando a formação de tumores (acúmulo de células cancerosas) ou neoplasias malignas. As causas de câncer são variadas, podendo ser externas ou internas ao organismo, estando inter-relacionadas. As causas externas referem-se ao meio ambiente e aos hábitos ou costumes próprios de uma sociedade. As causas internas são, na maioria das vezes, geneticamente pré-determinadas, e estão ligadas à capacidade do organismo de se defender das agressões externas (Sistema Imunológico ou acúmulo de mutações no DNA). A compreensão dos exatos mecanismos e a tentativa de inativar genes ou impedir as ações tóxicas de substâncias contribuirá para a elucidação de diversos pontos importantes para o entendimento da carcinogênese e, portanto, para novas estratégias de tratamento e de prevenção do câncer. O presente estudo tem como objetivo, avaliar o efeito da substância pura, morelloflavona, isolada da folha de Garcinia xanthochymus, planta típica do Cerrado no Estado de São Paulo, conhecida por sua variada atividade biológica (analgésica, antibacteriana, antioxidante, antiviral e antitumoral) devido aos seus grupos de metabólitos: xantonas, flavonóides, fenóis e acridonas. Assim, foram realizados: o ensaio da Quinona Redutase em paralelo com o ensaio do Violeta Cristal para análise da viabilidade celular em células de hepatocarcinoma murino (Hepa 1c1c7); o ensaio de Sulforrodamina B para análise da viabilidade celular em células de hepatocarcinoma humano (HepG2) e o ensaio do Cometa nos protocolos de genotoxicidade e antigenotoxicidade em células... (Resumo completo, clicar acesso eletrônico abaixo)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Medicina Veterinária - FCAV
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The purpose of the present investigation was to characterize the pitanga seeds on centesimal composition, and also to evaluate its antioxidant potential and fatty acid profile. For obtaining the extract, the dehydrated and ground seeds were treated with ethyl alcohol for 30 minutes, at a proportion of 1:3 of seeds:ethyl alcohol, under continuous agitation at room temperature. Afterwards, the mixture was filtered and the supernatant was placed into a rotoevaporator at 40ºC for determining the extract’s dry matter yield, by direct weighing. According to the results, the seeds of cherry showed high amounts of carbohydrates, and offer relevant content and antioxidant activity of phenolic compounds. In the seed oil, cherry high lighted a higher percentage of unsatured fatty acids, oleic being the main component.
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Pós-graduação em Agronomia (Energia na Agricultura) - FCA
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Pós-graduação em Biologia Geral e Aplicada - IBB
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There are cassava varieties that present compounds as carotenoids, beta-carotene, lycopene and minerals important for human and animal health. The present study evaluated the antioxidant activity of the white, yellow and pinkish varieties of Manihot esculenta, by mean of the DPPH test and by the ferrous ion-chelating activity. Furthermore, the total phenols, carotenoids, beta-carotene, lycopene and zinc contents were also determined. Utilizing the DPPH test it was possible to find that extracts of boiled samples presented higher antioxidant activity (89.53% - pinkish) in comparison to the fresh samples (1.97% - white). For the ferrous ion-chelating test, the highest activity was found for the boiled pinkish variety extract (63.43%) and the lowest was for fresh yellow extract (17.34%) the white sample did not present activity. The highest concentration of total phenols and zinc content was obtained for the boiled pinkish variety extract 136.12 mg EAG/g of extract and 0,811ppm, respectively, in the concentration of 1000 µg/mL. The pinkish variety presented also higher quantity of pigments, including carotenoid (29.40 µg/g), beta-carotene (9.14 µg/100g) and lycopene (68.92%). According to the results obtained in this study it was possible to conclude that the yellow and pinkish varieties of M. esculenta present quantity of phenolic compounds and minerals sufficient to attribute the antioxidant activity and may thus contribute to reduce oxidative damage and be used as nutraceuticals or directly ingested in the diet to maintain good health.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Ciência Odontólogica - FOA
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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The education research guidelines have shown the important contribution of the investigations that focus on analysis of the discursive dimension of teaching and learning of Science in actual classroom. An interesting proposal to analyze the effectiveness of an educational activity is to assess the potential of investigative activities in the development of argumentation in science classes. Several studies have taken into account the use of argument in the classroom as a way to provide students with new ways to know the science. Argument refers to the process of associating components that play a central role in the construction of explanations, models and theories. In order to investigate the potential of these activities took place the application of investigative activities with third-year high school students, recorded in audio and video, focusing on the development of the argument. The search, conducted ranks as a qualitative research with characteristics of a case study. The arguments collected during the activities contained the students' conceptions about the concepts discussed and all were recorded in audio and video. With the encouragement of the argument by the investigative activity we evaluate the learning experienced by the speech of students. It may be noted that students have appropriated the concept of oxidation involving electron transfer, thus the activity reached the goal, so that was planned, making it effective for the introduction of electrochemical concepts