Produção de cerveja, utilizando méis de diferentes origens botânicas como adjuntos

This study aimed to produce beer, using different botanical origins of honeys (orange, eucalyptus and wild), as malt adjuncts, and their Physical-chemical and sensorial characterizations. The production was made with malt, water, hops and honey. All musts were adjusted to 12 Brix, and the concentration of honey in the formulation was 45% (based on the extract), except for the control (0%). The physical and chemical analysis were performed on malt (extract content), honey (pH, free acidity, lactonic acidity, total acidity, color, turbidity, extract content, moisture content, reducing sugar, total reducing sugar and sucrose) in wort (content extract, pH, color, turbidity, fermentability ,bitterness and total acidity) and beer apparent extract, apparent fermentability, real extract, real fermentability, alcohol content, pH, total acidity, total foam, foam density , bitterness, carbon dioxide, color and turbidity). Sensory analysis was performed by nine-points hedonic scale testing. The attributes evaluated were appearance, aroma, flavor and overall. The results were submitted to ANOVA and means compared by Tukey testing at a 5% of probability. Beer with honey as adjuncts’ had high fermentability and low content of fat, compared to the pure malt beer. The addition of honey as an adjunct did not affect the majority of the physical-chemical parameters, except for turbidity, whereas beer with honey showed the highest value for this feature, in addition, it has also presented their biterness differences the values for beer with honey were lower. The different types of honeys did not affect the acceptability of beer, however, the beer with honey showed greater acceptance between beer with malt and honey

Estudo para determinação da kVp em equipamentos de raios X convencional

The quality assurance control program (QACP) in clinical radiology is very important to acquire, image quality, patient dose reduction and cost for the institution. The verification of the real tension on the x ray tube, it is one of many parameters that may be determined on a QACP. This act on image quality as absorbed dose in patient. Once proved the importance of this fact, this study come up with the determination of tension to any X ray tube used on medical routine, on quick, safe and low cost manner. To reach the aim of this study, the methodology consisted on measuring expose rates (ER) using different thicknesses of copper (Cu) plates like filters and relating these results with Half Layer Value (HLV). Afterwards, the HLV was associated to real tension that was acquired with kilo voltage of peak (kVp) measurers used on clinical routine. So walking in this path, when performed the ER, on any X ray tube, it’s possible acquire the HLV and consequently the real kVp, considering measures obtained before, on the methodology of kVp estimative development

Análise da confiabilidade de equipamentos em uma indústria química com aplicações de ferramentas da melhoria contínua

The constant search for improvements and the survival of organizations makes the strategic guidelines are deployed and executed at the operational levels. This work is the approach to critical analysis of the equipment of a chemical industry through a case study based on the classification of each equipment manufactures through qualitative and quantitative analysis on the pillars of maintenance costs, loss of production, MTBF, contribution margin, Health Safety and Environment (SHE). From this study and future data collection, along with the flow diagram show the main equipment that should be special attention. To this can be prepared an action plan with deadlines and responsible. With the results one can measure the maintenance costs, loss of production and technical availability of the plant, with future gains

Compostos bioativos presentes em cultivares de maracujá

A produção de maracujá vem ganhando grande importância no Brasil, notadamente a partir das últimas três décadas, o que coloca o país numa situação de destaque no ranking mundial, sendo o maior produtor do mundo. As principais espécies produzidas e exploradas comercialmente são: Passiflora edulis Sims f. flavicarpa Deg., o maracujá amarelo ou azedo e Passiflora alata Dryand, o maracujá doce. Apesar de serem espécies bem difundidas, há poucos estudos que as relacionem. Desta forma, o presente trabalho objetivou comparar as polpas das duas espécies, avaliando suas semelhanças e diferenças através de testes físico-químicos e determinando seus compostos bioativos. O estudo foi conduzido no Laboratório de Controle de Qualidade de Alimentos, no Departamento de Alimentos e Nutrição, da Universidade Estadual Paulista “Júlio de Mesquita Filho”, Faculdade de Ciências Farmacêuticas, campus Araraquara. Para analisar e comparar as espécies estudadas foram utilizadas amostras “in natura” e congeladas de ambas as espécies e foram determinados os compostos bioativos (carotenoides totais, fenólicos totais e flavonóides totais), ácido ascórbico, acidez total titulável (ATT), atividade sequestrante de radicais livres (DPPH) e sólidos solúveis totais (SST). Todas as análises foram realizados em triplicata. Em todas as determinações, o maracujá doce, Passiflora alata Dryand, apresentou valores menores em relação ao maracujá azedo, Passiflora edulis Sims f. flavicarpa Deg..Os valores demonstram maiores quantidades de antioxidantes em maracujá amarelo em relação ao maracujá doce. Também demonstram que a indicação de consumo para Passiflora alata Dryand, é do fruto “in natura”, uma vez que para haver industrialização e processamento, há necessidade de maior acidez. Já Passiflora edulis Sims f. flavicarpa Deg. demonstra-se adequado para a industrialização.

Desenvolvimento e validação de método analítico para a quantificação de ofloxacino colírio por turbidimetria

O ofloxacino, uma fluorquinolona de segunda geração, foi sintetizada em 1982, apresenta eficácia e segurança no tratamento comprovadas. A determinação da potência dos antimicrobianos é importante no controle e na garantia da qualidade das preparações farmacêuticas e faz-se necessário o desenvolvimento de procedimentos práticos e econômicos que possam ser validados e aplicados no doseamento desses fármacos. Dentre os ensaios microbiológicos, os mais comumente empregados são o de difusão em ágar e o turbidimétrico. Na literatura, apenas são encontradas descrições de ensaios para o ofloxacino utilizando o método de difusão em ágar. O método turbidimétrico tem como uma das principais vantagens, a necessidade de menor tempo de análise. O método consiste na avaliação quantitativa de substâncias em função da turbidez de suas suspensões, proporcional a seu poder de difração sobre luz incidente (efeito Tyndall) (FB 5, 2010). O objetivo desse trabalho foi desenvolver um método microbiológico analítico para quantificação do ofloxacino que possa ser usado para análises rotineiras em laboratórios de controle de qualidade. Os parâmetros estudados para a validação do método analítico para quantificação do ofloxacino não atenderam a todas as especificações recomendadas. Assim sendo, pode-se concluir que este trabalho de conclusão de curso, não conseguiu atingir seu objetivo que era de desenvolver e validar uma metodologia analítica. O método demonstrou desenvolvimento complexo e trabalhoso e não apresentou o paralelismo e exatidão necessários para validação

Desenvolvimento e validação de método analítico para a quantificação de teicoplanina injetável por turbidimetria

A teicoplanina é um complexo antibiótico glicopeptídico derivado do Actinoplanes teichomyceticus, ativo contra bactérias Gram-positivas resistentes a outros antibióticos. Seu espectro de ação é similar ao da vancomicina, sendo, porém mais ativo para Streptococcus faecalis e Clostridium difficile. Seu uso é indicado para profilaxia de endocardite, peritonite, osteomielite e para septicemia estafilocócica. No Brasil, a teicoplanina é comercializada sob a forma farmacêutica de pó liofilizado, que deve ser reconstituído antes da administração. O medicamento de referência é o Targocid®, produzido pelo laboratório Sanofi-Aventis, em duas apresentações, 66 mg/mL e 133 mg/mL. A teicoplanina, bem como a vancomicina, inibe a síntese da parede celular bacteriana, pois a molécula se liga ao precursor da parede D-alanil-D-alanina, formando um complexo, impedindo a ligação à porção terminal do peptidoglicano, que é o alvo das enzimas transglicolase e transpeptidase. Desse modo, não há incorporação de aminoácidos aos glicopeptídeos integrantes da parede celular das bactérias Gram-positivas. No estudo de validação, foram aplicados os parâmetros de linearidade, intervalo, precisão, sensibilidade, especificidade, exatidão e robustez. O método desenvolvido e validado para a quantificação de teicoplanina pó liofilizado foi: Ensaio microbiológico por turbidimetria na faixa de concentração de 20,0 a 80,0 μg/mL, utilizando o micro-organismo Staphylococcus epidermidis ATCC 12228 IAL 2150. Os parâmetros estudados para a validação do método turbidimétrico atenderam a todas as especificações para a adequada quantificação de teicoplanina na forma farmacêutica pó liofilizado

O efeito da autocorrelação no desempenho dos gráficos de X e R e dos gráficos de X e S²

Control charts are very important tools in statistical quality control of industrial processes and its use started last century. Since its development, the charts have always been attributed to independent processes, i.e. without any correlation between samples. But nowadays, with the high level of automation in the industrial environment, it is noticeable the autocorrelation factor between samples. The main Xcharts used in monitoring quality characteristics represented by continuous variables are the mean (X ), amplitude (R) and variance (S²). Therefore, this work aims to analyze the performance of X and R charts and in of X and S² charts with different sample sizes (4 and 5) for monitoring autocorrelated processes. Through computer simulations using the Fortran software and the use of mathematical expressions was possible to obtain data and performance analysis of the detection power charts for independent observations and for autocorrelated observations according to the model AR (1). The results show that the effect of autocorrelation reduces the ability of monitoring the control charts and that, the greater this effect, the slower the chart becomes in misfits signaling

Método de Taguchi aplicado a um processo de corte por fusão de um tecido sintético

A company must have full knowledge and control of its operations so as to meet the market requirements and meet their production goals. Thus this paper uses the Taguchi method to extend the operational control of a cutting process by fusion of a synthetic fabric in the longitudinal direction. For process analysis and tracking of possible causes of the problem techniques of Production Engineering as the cause and effect diagram, also known as Ishikawa diagram, and design of experiments were used, the last one was applied to the design techniques of Taguchi. Finally the preparation method of understanding and design of experiment was due to the use of the software MINITAB v15 ®, which showed that the speed of rolling the fabric after cutting is crucial for controlling the entire operation

Análise da implantação do TPM em uma empresa do ramo farmacêutico

Through observation of the production process industries today, one can encounter the needs of the large uncertainties related improvements and changes in the production environment, a fact that inspired the search for solutions that can respond quickly to these changes. Thus, this paper describes the review of implementation of TPM (total productivity management), which aims to optimize two distinct processes in the Vale do Paraíba´s pharmaceutical industry one of through the pillar of specific improvement. The main objective is to propose an efficient alternative to proposing loss management processes by identifying and eliminating the same in a systematic process. To develop this analysis was necessary to explore concepts of TPM and tools that help in taking data, identification and clarification of the phenomena that cause failures in the process, which were essential to ensure the development of the analysis. The concepts covered are usually presented during an undergraduate degree in Engineering. Data compiled by the analysis are able to serve as a strategic benchmark for decision making by managers, providing alternative response variables and uncertainty of the organizational environment, a fact that facilitates the management of human resources and productive

Análise de matérias primas e solução comercial empregada na perfusão e no transporte de órgãos destinados ao transplante

A solução HTK (histidina, triptofano e cetoglutarato) foi especialmente desenvolvida para preservar a heterogeneidade morfológica e bioquímica dos órgãos destinados ao transplante. Contém exclusivamente substâncias existentes no organismo tais como cloretos de sódio, potássio e magnésio, histidina, triptofano, manitol e cetoglutarato de potássio. Sua composição promove a inibição de todos os processos de ativação muscular, nervosa ou endócrina nas estruturas estimuláveis das membranas. Nos compêndios oficiais encontram-se métodos de análise qualitativa e quantitativa para matérias primas. Análises das matérias primas foram realizadas nos Laboratórios de Controle de Qualidade da faculdade de Farmácia e Laboratório de Eletroanalitica (NDcom) do Instituto de Química aplicando os métodos preconizados nos códigos oficiais. Os resultados obtidos com as matérias primas foram satisfatórios e confiáveis. Os mesmos métodos não possibilitaram a análise da Solução HTK acabada como proposto inicialmente. Esses métodos não apresentaram sensibilidade suficiente para a determinação das matérias primas empregadas no preparo desta solução, pois estas se encontram em concentrações bastante reduzidas, necessitando métodos mais sensíveis que realizem análise de traços de eletrólitos.

Determinação por meio de planejamento de experimentos da influência do lixamento nas medidas de dureza com durômetro portátil de método UCI

The hardness has an important role in quality control, in research studies and metallurgical and mechanical specification, selection and comparison of various materials. This property is of extreme importance in the oil industry because it is a determining factor to ascertain the safety of the material used in pressure vessels and pipelines. Due to the inability to stop the equipment while checking the hardness, the hardness testers are widely used portable method UCI, its great advantage is the fact that an essay fast, simple realization and not be considered a non-destructive testing with a good relationship money. The objective is to determine if there is significant difference in hardness measurements between 80 and 1200 sandpaper using a portable hardness tester UCI method, the material applied in gas storage spheres composition ASTM 516 Gr 70. After determining the number of homogeneity, we performed the hardness profile to isolate the major factors influencing the hardness part: cold rolling and segregation of impurities. Factors Cooling and sanding were analyzed using the method of design of experiments (DOE), in which it was demonstrated that neither variables nor their interactions, has significant influence on the hardness measurements by portable MIC 10. This fact will lead to reduction in time and cost for surface preparation

Aplicações práticas de proteção radiológica nas áreas de medicina nuclear e radiodiagnóstico em instalações hospitalares

After the discovery of ionizing radiation, its applications in various fields of science began to take significant proportions. In the case of medicine, there are the application areas in radiotherapy, diagnostic radiology and nuclear medicine. It was then necessary to create the field of radiological protection to establish the conditions necessary for the safe use of such ionizing radiation. Apply knowledge obtained during the graduation stage and in the practice of radiological protection in the areas of nuclear medicine and diagnostic radiology. In the area of nuclear medicine, tests were made in the Geiger-Muller counters (GM) and the dose calibrator (curiometer), the monitoring tests of radiation, waste management, clean of the Therapeutic room and testing the quality control of gamma-chambers. In the area of radiology, were performed tests of quality control equipment for conventional X-ray equipment and x-ray fluoroscopy, all following the rules of the National Health Surveillance Agency (ANVISA), and reporting of tests. The routine developed in the fields of nuclear medicine in hospitals has proved very useful, since the quality control of GM counters contribute to the values of possible contamination are more reliable. The control of dose calibrator enables the patient not to receive different doses of the recommended amounts, which prevents the repetition of tests and unnecessary exposure to radiation. The management of waste following the rules and laws established and required for its management. Tests for quality control of gamma chambers help to evaluate its medical performance through image. In part of diagnostic radiology, tests for quality control are performed in order to verify that the equipment is acceptable for usage or if repairs are needed. The knowledge acquired at the internship consolidated the learning of graduation course

Considerações sobre o gerenciamento da construção civil em obras residenciais verticais

The civil construction is an industrial sector of great economic importance and that it comes exponentially growing in the country. However, this activity is deficient in its management processes, and in this context that the management of construction as a way of organizing and controlling all the technical and construction of an enterprise. The literature shows that the manager has a key role throughout the process of planning, execution and analysis of the results of the work being of prime importance that all steps have its due attention in order to avoid any technical problems or lack information. The management’s main objective is the transparency of technical and financial information to investors and their assessments of physical and financial performances of the work intervened positively in quality, deadlines and costs. In this sense, this paper aims to present consideration about the proper management of a residential development in vertical construction

Implementação de FMEA em uma linha de produção de caminhonetes

Currently the quality of a final product is as important as the price they pay for it, to the satisfaction of having something durable and exercising its function as well as has been informed. This work aims to define the stages of the process of implementing a new project in a production line in order to ensure product quality and process, defining each step with those responsible for each area of the factory, implementing new tools and methods, improving process with lessons learned from previous projects, gathering information on the production line to analyze the need for rigorous controls to prevent errors. With the definition of schedule after studies of the plant where the new project was implemented, establish the goals of each phase to ensure the quality of process and product

Gama Câmara CZT: alteração de paradigmas em aquisição de imagens de medicina nuclear

Nuclear medicine is a medical specialty related to imagery that deals with imaging techniques, diagnosis and therapy, allowing observing the physiological state of tissues noninvasively by marking the molecules participating of these physiological processes with radioactive isotopes, thus creating the called radionuclides. The image of a radionuclide is one of the most important applications of radioactivity in nuclear medicine. The equipment’s of nuclear medicine imaging use the principle of radiation detection, turning it into an electrical signal which, through specific algorithms, allows forming tomographic images that provide information about the functional status of organs. New detection systems have been developed for tomographic acquisitions using solid state detectors. These devices use crystals of cadmium zinc telluride (CdZnTe). Some of the advantages of this detector are a significant improvement of signal to noise ratio, the increased spectral and spatial resolution, which in sum, result in greater clarity of the images obtained, opening new perspectives for imaging protocols previously unattainable. In contrast, all other gamma-cameras equipped with vacuum tubes have remained relatively unchanged for nearly fifty years. In these gamma-cameras, the images are obtained using two steps significantly less efficient: the gamma rays are converted to light through a first device, and then the light is converted into an electrical signal through a second device. One of functions the Medical Physicist is related to the quality control of equipment. This control ensures that the information and images provided are true and thus credible to be used in medical reports. To perform this type of analysis the physicist must understand the performance characteristics and operation of all equipment of the department concerned; besides, in the absence of specific legislation, proposing...(Complete abstract click electronic access below)