Modelo sistêmico de ocorrência de ações coletivas: um estudo multicaso na comercialização de frutas, legumes e verduras

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O efeito da autocorrelação no planejamento das cartas de controle de x̄ e EWMA

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Consenso em reumatologia pediátrica: parte II - definição de melhora clínica para o lúpus eritematoso sistêmico e dermatomiosite juvenil

OBJETIVO: avaliar as medidas de atividade e critérios de melhora clínica para o lúpus eritematoso sistêmico juvenil (LESJ) e dermatomiosite juvenil (DMJ), desenvolvidos por meio de consenso entre especialistas. MÉTODOS E RESULTADOS: para o LESJ, as medidas essenciais em cinco domínios e as respectivas variáveis foram: 1) avaliação global pelo médico por escala analógica visual de 0-10 cm; 2) avaliação da qualidade de vida relacionada à saúde (índice Físico - CHQ-PF50); 3) avaliação da atividade pelos pais/paciente por escala analógica visual de 0-10 cm; 4) avaliação renal (proteinúria 24 h); e 5) avaliação global da atividade por instrumento específico (SLEDAI ou ECLAM). A definição preliminar de melhora clínica para o JSLE foi: melhora > 50% em pelo menos 2 das 5 variáveis e não mais que uma com piora > 30%, a qual não pode ser a proteinúria de 24h em casos com envolvimento renal. Os seis domínios e as respectivas variáveis selecionadas para a atividade na DMJ foram: 1) avaliação global pelo médico por escala analógica visual de 0-10 cm; 2) avaliação da força muscular proximal por meio de teste específico - CMAS-Childhood Myositis Assessment Scale 0-52; 3) avaliação da capacidade funcional (CHAQ); 4) avaliação da atividade pelos pais/paciente por escala analógica visual de 0-10 cm; 5) avaliação da qualidade de vida relacionada à saúde (Índice Físico - CHQ-PF50); 6) avaliação global da atividade por meio de instrumento específico (DAS - Disease Activity Score). A definição preliminar de melhora clínica para a DMJ foi: pelo menos 3 de quaisquer das 6 variáveis com melhora > 20% e não mais que uma com piora > 30%, a qual não pode ser o CMAS. CONCLUSÕES: estas variáveis foram testadas em uma casuística representativa e mostraram propriedades estatísticas adequadas de responsividade e validade discriminativa, podendo ser estudadas em ensaios terapêuticos.

Ensino de conceitos físicos de termologia para alunos com deficiência visual: dificuldades e alternativas encontradas por licenciandos para o planejamento de atividades

Relatamos aqui resultados parciais de um estudo que analisou o desempenho de futuros professores quando, durante o desenvolvimento de uma disciplina de Prática de Ensino de Física, foram solicitados a planejar, elaborar e ministrar, em situações reais de sala de aula, tópicos de ensino de termologia a uma turma de estudantes, dentre os quais se incluíam alunos com deficiência visual. Os dados coletados mostram que as principais dificuldades apresentadas pelos futuros professores referem-se à abordagem do conhecer fenômenos físicos como dependente do ver. Por outro lado, como alternativas, os futuros professores mostraram criatividade em superar atitudes passivas relativas à problemática educacional considerada e a elaboração de estratégias metodológicas destituídas da relação conhecer/ver.

Áreas ecologicamente estáveis como instrumento de planejamento ambiental

The population growth phenomenon, coupled with recent urbanization, is seen in all continents and generates huge pressures on the physical and biotic environment, resulting in floods in several areas, desertification in others, and also various forms of pollution that cause serious problems to human health. It is appropriate to ask, what actions can be implemented in consolidated urban areas to improve the quality of life in this environment? What growth alternatives present themselves to today's society in order to keep an acceptable level of environmental quality in urban centers? A possibility is presented herein, stemming from the application of the Biotope Area Factor (BAF; www.stadtentwicklung.berlin.de) to an area of a Brazilian municipality. Current growing waterproofing requirements fur lots of the area were assesed, comparing them with those that would be desirable by the implementation of the BAF. The associated costs of this deployment are also discussed.

Planejamento de Fontes Reativas em Sistemas de Energia Elétrica utilizando a técnica de Decomposição de Benders e o algoritmo de Branch-and-Bound

This paper presents the Benders decomposition technique and Branch and Bound algorithm used in the reactive power planning in electric energy systems. The Benders decomposition separates the planning problem into two subproblems: an investment subproblem (master) and the operation subproblem (slave), which are solved alternately. The operation subproblem is solved using a successive linear programming (SLP) algorithm while the investment subproblem, which is an integer linear programming (ILP) problem with discrete variables, is resolved using a Branch and Bound algorithm especially developed to resolve this type of problem.

Estudo comparativo das complicações terapêuticas no Lúpus Eritematoso Sistêmico e nas glomerulopatias idiopáticas.

PURPOSE: To evaluate the therapeutic complications due to the use of immunosupressors in patients with nephropathy. METHODS: 76 patients who had used steroids and cyclophosphamide were retrospectively studied. The cases were divided into three groups: G1= 15 patients with Systemic Lupus Erythematosus without renal lesion; G2= 33 patients with lupus nephritis and G3= 28 patients with nephrotic syndrome owing to idiopathic glomerulopathy. RESULTS: There were no differences related to time of follow up (G1= 42.4 +/- 51, G2= 52.3 +/- 51, G3= 41.8 +/- 47.8 months), total used dosage of steroids (G1= 20, G2= 28, G3= 16 grams) and time of drug use (G1= 20, G2= 26, G3= 14.5 months). About cyclophosphamide use, there was no difference in the percentage of patients who used it (13% in G1, 51% in G2, 28% in G3), but the patients from G1 received lower total dosage than those from G2 (p<0.05). Cushingoid appearance, epigastric distress, psychiatric disorders, diabetes mellitus and ocular alterations occurred in all the three groups, with no statistically significant differences. The infections complications, those considered more severe clinically, were more frequent in G2 (G1= 6%, G2= 15%, G3= 0% - p<0.05), the same occurring with the deaths (7% in G1, 30% in G2, 0% in G3 - p<0.05). CONCLUSION: In patients with lupus nephritis there were more infections complications owing to prolonged immunosuppresion what may indicate a severity marker of this type of lesion.

Sistemas para liberação colônica: Uma alternativa para a veiculação de fármacos para efeito local ou sistêmico

Problems related to the systemic administration of drugs, such as biodistribution, difficulty of targeting, necessity of high doses to achieve adequate levels of the drug in specific sites, toxicity, and undesirable side effects have lead to the development of systems able to direct the drug to specific sites in the body. Among the possible organs to the targeting of drugs, the colon can be used for local and systemic therapies. By developing such systems some models have been tested, using pH dependent release, release controlled by enzymatic degradation, time controlled release systems and pressure controlled release systems. This review presents an overview of the colonic release of drugs and the strategies used to achieve such targeting.

Planejamento urbano e geração de empregos: A cidade de São Paulo (Brasil) nos anos 90

This paper attempts to show the convergence of principles between labor market politics and urban management, emphasizing it relationship with pro-market theories. Limits and possibilities of the application of this theoretical frame were investigated by examining the changes in both composition and stock of labor in three important business spaces in São Paulo: Central Area, Paulista Avenue and the new expansion front near Luiz Carlos Berrini and Águas Epraiadas avenues. Despite the claims of pro-market theoreticians, information provided by Labor Ministry showed that between 1996 and 2000, a re-arrangemenet of the workers contingent among the investigated areas occurred, instead of the expected growth. The favorable behavior registered in Berrini/ Águas Espraiadas, because of the bulky volume of investments, took place at the same time that a decrease of labor in the Downtown; meanwhile, in Paulista, a growth of the number of employees was observed, in spite of the landing less elevated of investments.

Dificuldades e alternativas encontradas por licenciandos para o planejamento de atividades de ensino de óptica para alunos com deficiência visual

Partial outcomes of a study aimed to verify future High School teachers performance during the development of a Teaching Practice undergraduate course. The student teachers were asked to plan, elaborate and teach, in a classroom situation, optics topics to a class which included visual handicapped pupils. Data analysis shows that the main difficulties found by the student physics' teachers are related to which approach will be used to perceive phenomena dependent on vision and also to the need to break away from traditional pedagogy.. On the other hand, as alternatives, future teachers have shown creativity in order to overcome passive aptitudes related to this educational problem, working out methodological strategies that do not require the knowing/seeing relation, as well as, emphasizing oral communication within the physics teaching context. Copyright by the Sociedade Brasileira de Física.

Planejamento agrícola e implantação de sistema de cultivo de cana-de-açúcar com auxílio de técnicas geoestatísticas

Sugarcane is one of the most important crops of the Brazilian agribusiness and this importance justifies the use of techniques that allow the implementation of cultivation systems capable of reducing the variability of soil characteristics and the establishment of efficient agricultural planning. The aim of the present work was the planning and implementation of cultivation systems for sugarcane using geostatistical techniques, in the Pereira Barreto region, SP. An area of 505 ha was mapped using the global positioning system (GPS) and a Digital Elevation Model was elaborated (MDE). Soil samples were collected for 0-0.25 m depth, in each 7 ha, for their chemical attributes and texture characterization. Data were analyzed by descriptive statistics and geostatistics. The determination of the spatial distribution of soil granulometric and chemical attributes allowed the allocation of the studied sugarcane varieties according to soil fertility and clay content. The kriging maps of soil granulometric and chemical attributes brought useful information to the establishment of production environments with different soil and crop managements. The identification of different environments by means of geostatistical techniques allowed the precise planning of the sugarcane cultivation, as well as the adequacy of fertilization practices and the allocation of suitable sugarcane varieties adapted to the conditions imposed by differences in the soil attributes.

Planejamento, síntese e avaliação farmacológica de compostos híbridos potencialmente ativos para o tratamento da anemia falciforme

Sickle cell disease (SCD) is a hereditary hemolytic anemia caused by the inheritance of one S hemoglobin gene from each ancestor. Patients with SCD present increased circulating levels of cytokines, including TNF-alpha (TNF-α). Hydroxyurea (HU) is the available therapeutically strategy for treatment; it acts as a source of nitric oxide and benefits patients by increasing the levels of fetal hemoglobin (HbF). Thus, within one research line that aims at finding new drugs, a series of compounds with TNF-α inhibition and nitric oxide donation properties have been synthesized in order to explore possible synergism of actions beneficial in the treatment of the disease. Six compounds were synthesized: five derivatives of organic nitrates and one of sulfonamide. The compounds, (1,3-dioxo-1,3-dihydro-2Hisoindol-2-yl) methyl nitrate (compound I); (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) ethyl nitrate (compound II); 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound III);4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxybenzenesulfonamide (compound IV); 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound V) and 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]ethyl nitrate (compound VI), were synthesized using linear synthetic methodology, with excellent overall yields. All compounds showed anti-inflammatory and analgesic effects with a reduction in 43%-65% of ear edema in mice and a reduction of 25%-42% of writhing induced by acetic acid. All compounds showed comparable reductions in the leukocyte infiltration capacity and ability to generate nitric oxide. The aryl compounds (III, IV and V) presented less mutagenic activity compared to compounds I, II and VI according to the salmonella mutagenicity assay (Ames test). Compounds IV and VI showed activity in K562 culture cells, with increases in gamma globin gene expression to levels higher than with hydroxyurea suggesting a potential to increase fetal hemoglobin. This data set characterizes new potentially useful drug candidates for the treatment of symptoms of sickle cell anemia.