On designing linearly-tunable ultra-low voltage CMOS gm-C filters

A linearly-tunable ULV transconductor featuring excellent stability of the processed signal common-mode voltage upon tuning, critical for very-low voltage applications, is presented. Its employment to the synthesis of CMOS gm-C high-frequency and voiceband filters is discussed. SPICE data describe the filter characteristics. For a 1.3 V-supply, their nominal passband frequencies are 1.0 MHz and 3.78 KHz, respectively, with tuning rates of 12.52 KHz/mV and 0.16 KHz/m V, input-referred noise spectral density of 1.3 μV/Hz1/2 and 5.0μV/Hz1/2 and standby consumption of 0.87 mW and 11.8 μW. Large-signal distortion given by THD = 1% corresponds to a differential output-swing of 360 mVpp and 480 mVpp, respectively. Common-mode voltage deviation is less than 4 mV over tuning interval.

Search for associated Higgs boson production WH→WWW *→l±νl′±ν′+X in pp̄ collisions at s=1.96TeV

We present a search for associated Higgs boson production in the process pp̄→WH→WWW*→l±νl′±ν′ +X in final states containing two like-sign isolated electrons or muons (e±e±, e±μ±, or μ±μ±). The search is based on D0 run II data samples corresponding to integrated luminosities of 360-380pb-1. No excess is observed over the predicted standard model background. We set 95% C.L. upper limits on σ(pp̄→WH) ×Br(H→WW*) between 3.2 and 2.8 pb for Higgs boson masses from 115 to 175 GeV. © 2006 The American Physical Society.

Digital system design process automation using place/transition petri nets

The constant increase in digital systems complexity definitely demands the automation of the corresponding synthesis process. This paper presents a computational environment designed to produce both software and hardware implementations of a system. The tool for code generation has been named ACG8051. As for the hardware synthesis there has been produced a larger environment consisting of four programs, namely: PIPE2TAB, AGPS, TABELA, and TAB2VHDL. ACG8051 and PIPE2TAB use place/transition net descriptions from PIPE as inputs. ACG8051 is aimed at generating assembly code for the 8051 micro-controller. PIPE2TAB produces a tabular version of a Mealy type finite state machine of the system, its output is fed into AGPS that is used for state allocation. The resulting digital system is then input to TABELA, which minimizes control functions and outputs of the digital system. Finally, the output generated by TABELA is fed to TAB2VHDL that produces a VHDL description of the system at the register transfer level. Thus, we present here a set of tools designed to take a high-level description of a digital system, represented by a place/transition net, and produces as output both an assembly code that can be immediately run on an 8051 micro-controller, and a VHDL description that can be used to directly implement the hardware parts either on an FPGA or as an ASIC.

Intensified peginterferon α-2a dosing increases sustained virologic response rates in heavy, high viral load hepatitis c genotype 1 patients with high low-density lipoprotein

BACKGROUND AND GOAL: Patients infected with hepatitis C virus (HCV) with elevated low-density lipoprotein (LDL) levels achieve higher sustained virologic response (SVR) rates after peginterferon (PegIFN)/ribavirin treatment versus patients with lower LDL. Our aim was to determine whether SVR rates in patients with low/elevated LDL can be improved by dose intensification. STUDY: In PROGRESS, genotype 1 patients with baseline HCV RNA≥400,000 IU/mL and body weight ≥85 kg were randomized to 48 weeks of 180 μg/wk PegIFN α-2a (40 kDa) plus ribavirin (A: 1200 mg/d; B: 1400/1600 mg/d) or 12 weeks of 360 μg/wk PegIFN α-2a followed by 36 weeks of 180 μg/wk, plus ribavirin (C: 1200 mg/d; D: 1400/1600 mg/d). This retrospective analysis assessed SVR rates among patients with low (<100 mg/dL) or elevated (≥100 mg/dL) LDL. Patients with high LDL (n=256) had higher baseline HCV RNA (5.86×10 IU/mL) versus patients with low LDL (n=262; 4.02×10 IU/mL; P=0.0003). RESULTS: Multiple logistic regression analysis identified a significant interaction between PegIFN α-2a dose and LDL levels on SVR (P=0.0193). The only treatment-related SVR predictor in the nested multiple logistic regression was PegIFN α-2a dose among patients with elevated LDL (P=0.0074); therefore, data from the standard (A+B) and induction (C+D) dose arms were pooled. Among patients with low LDL, SVR rates were 40% and 35% in the standard and induction-dose groups, respectively; SVR rates in patients with high LDL were 44% and 60% (P=0.014), respectively. CONCLUSIONS: Intensified dosing of PegIFN α-2a increases SVR rates in patients with elevated LDL even with the difficult-to-cure characteristics of genotype 1, high baseline viral load, and high body weight. Copyright © 2013 by Lippincott Williams & Wilkins.

Ambiente computacional para projetos de sistemas com tecnologia mista

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Caracterização química e energética de briquetes produzidos com rejeitos de resíduos sólidos urbanos e madeira de Eucaliptus grandis

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Efeito do ultra-som de baixa potência na reparação óssea em ratos sob ausência de carga: análise densitométrica e biomecânica

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Fertirrigação nitrogenada por gotejamento e época de aplicação foliar de ácido giberélico 'GA IND.3' em alface americana (Lactuca sativa L.)

Pós-graduação em Agronomia (Irrigação e Drenagem) - FCA

Sistema de tratamento anaeróbio, aeróbio e anóxico para águas residuárias de suinocultura: remoção de matéria orgânica, de nutrientes e de coliformes

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo longitudinal dos efeitos da deficiência estrogênica no fêmur de ratas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Alegorias da totalidade: as relações entre ciência e poesia em A máquina do mundo repensada, de Haroldo de Campos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo do comportamento dos gnaisses Casablanca, Juparaná Delicato e Giallo Falésia (Ceará - Brasil) em atmosfera salina

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Histórico e funcionamento das coletas cooperativada e autônoma de materiais recicláveis de Santa Gertrudes-SP e desenvolvimento de técnica para aferição de seus efeitos sobre o destino do lixo doméstico

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Períodos de interferência de plantas daninhas em algodoeiro cultivares BRS Safira e BRS Verde

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação das doses de cães submetidos a exames radiográficos de pulmão

This study aims to determine surface skin doses in dogs (with suspected pulmonary metastasis) submitted to chest X-rays using the technique of thermoluminescence dosimetry. Twenty seven exams from different dogs were performed at the Faculdade de Medicina Veterinária e Zootecnia da Universidade Estadual Paulista (FMVZ-UNESP/Botucatu). The doses were evaluated using thermoluminescent dosimeters of calcium sulphate doped with dysprosium (CaSO4:Dy) produced by the Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN). The pulmonary metastasis exams are carried out in three projections, one dorsal-ventral and two lateral-lateral. During the procedures the projection thicknesses and source-skin surface distances were registered. To simulate the dog phantom the dosimeters were positioned in a cubic simulator (30x30x30 cm) of polymethylmethacrylate (PMMA) filled with water and irradiated according to the parameters of projections with the X-ray energies ranging from 45 to 70 kV. To estimate the surface skin dose the dose-response curves were obtained for X-ray energies of 50 and 70 kV using the diagnostic X-ray beam machine of the Instruments Calibration Laboratory of IPEN for doses of 1.5, 2.0, 2.5, 3.5 and 4.0 mGy. The main difficulty of this work was the dog immobilization that is reflected in poor-quality diagnostic imaging and, consequently, demands the repetition of the exams, which contributes to the increase of the doses received by the animals being studied and the clinical staff. The doses evaluated in this type of procedure are between 0.43 and 4.22 mGy. This research has shown to be extremely important for the assessment of doses involved in veterinary diagnostic radiology procedures, and as a parameter in the individual monitoring of pet’s owners who assist the animal positioning and occupationally exposed workers of the Department of Veterinary Radiology