Comparison of initial loading doses of 5 mg and 10 mg for warfarin therapy

CONTEXTO:A melhor dose para o início do tratamento anticoagulante com varfarina vem sendo debatida nos últimos dez anos. Em nosso meio, não observamos nenhum estudo comparativo quanto a estas características.OBJETIVO:Comparar segurança e eficácia de dois esquemas de dosagem inicial de varfarina para tratamento anticoagulante.MÉTODOS:Foram estudados prospectivamente 110 pacientes de ambos os sexos, consecutivos, com indicação de anticoagulação por tromboembolismo venoso ou arterial. Durante os três primeiros dias de tratamento, estes pacientes receberam doses adequadas de heparina (RT - razão dos tempos - alvo entre 1,5 e 2,5) e 5 mg de varfarina, cuja dose foi reajustada a partir do quarto dia pelo Razão Normatizada Internacional - RNI (alvo entre 2 e 3). Esse grupo foi comparado com série histórica de 110 pacientes que receberam 10 mg nos dois primeiros dias, 5 mg a partir do terceiro dia, com ajuste posterior de dose baseado no RNI. Os desfechos foram: recorrência do tromboembolismo, sangramentos e tempo para alcançar níveis terapêuticos.RESULTADOS:A eficácia, a segurança e o tempo de internação foram similares entre os grupos. O grupo que recebeu 10 mg atingiu níveis terapêuticos mais precocemente (média de 4,5 dias × 5,8 dias), sendo as doses na alta menores e os níveis terapêuticos mais adequados na primeira visita de retorno.CONCLUSÃO:O esquema de dosagem de 10 mg proporcionou menor tempo para alcançar nível terapêutico, com menores doses de varfarina na alta e RNI mais adequado no retorno.

Significados atribuídos por graduandos de enfermagem aos cuidados paliativos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estratégias de leitura e o ensino do ato de ler

Pós-graduação em Educação - FFC

O imaginário coletivo de estudantes de psicologia sobre distúrbios psicossomáticos

Pós-graduação em Psicologia - FCLAS

Parkinson's disease severity and motor subtype influence physical capacity components

The severity of Parkinson's disease (PD) and PD's motor subtypes influence the components of physical capacity. The aim of this study was to investigate the impact of both PD severity and motor subtype in the performance of these components. Thirty-six PD patients were assigned into four groups: Tremor (TD) initial and TD mild, akinetic-rigid (AR) initial, and AR mild. Patients' strength, balance, coordination, mobility and aerobic capacity were evaluated and groups were compared using a two-way ANOVA (severity and subtype as factors). AR presents a poorer performance than TD in almost all tests. Also this performance was worsened with the advance of the disease in AR, contrary to TD. We conclude that AR and TD subgroups are different about their performance on physical capacity components, moreover, this performance worsens with the advance of the disease of the AR group, but not for TD.

Monitoring muscle damage markers during a four-week downhill walking exercise program

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Conservação pós-colheita de melões inteiros e minimamente processados

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Pitaya: melhoramento e produção de mudas

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Discrepâncias de assentamento ocorrido em coroas totais metálicas, com e sem alívio interno, variando-se os términos cervicais e os agentes cimentantes

Pós-graduação em Odontologia Restauradora - ICT

Biometry by ultrasonography of the epaxial and pelvic musculature in equines trained with Pessoa's rein

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeito do fosfito de potássio isolado e em mistura com fungicidas no controle da requeima do tomateiro

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Potencial predatório de Carabidae e Staphylinidae (Coleoptera) sobre a lagarta-da-soja

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Risk factors that may signify a propensity to the use of drugs in students at a public university

Introduction: We sought to evaluate the risk factors that may increase the propensity to use licit and illicit drugs among students at a public university. Methods: The project involved students (n = 268) enrolled in the first and fourth years of courses in the areas of the social and biological sciences at a public university. Data collection was conducted by means of self-administered, semistructured questionnaires, based on such standardized assessment instruments as Audit, Assist, Cage and Duse. Collected data were analyzed quantitatively by calculating the percentages and evaluating the data in terms of categories of risk, classifying them by age, gender, religion, schooling, use (before or after entering university) and contexts of use. By means of this survey the researchers were able to correlate the use of drugs to the risk factors that might increase the students’ propensity to use these substances. Results: The results revealed a high proportion of current drug-using students, but showed no significant differences between the first and fourth year students as regards contexts of use. However, 67% of students regarded the university environment as encouraging the use of drugs. Students pointed to such major risk factors as friends’ and fellow-students’ influence, university parties, excessive curiosity and desire to experiment. Conclusion: Due to the high rate of drug use among university students, by the determination of the risk factors related to the university environment and also knowing that the process of addiction is one of growing chemical dependence, the importance of the development and implementation of public health policies at all levels, especially in terms of approaches and specific interventions addressing this population, should be noted.

Atitudes sociais em relação à inclusão: o curso de Pedagogia da Faculdade de Ciências e Tecnologia da UNESP

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Programa de Atividade Física Adaptada com Uso de Vídeo Game: o que Pensam os Alunos?

Exergames are a new educational tool, and have been used by teachers in physical education classes because it is an activity that provides entertainment and caloric expenditure. The goal of this study was to verify the opinion of students in an elementary school class on a program of adapted physical activity using the videogame, developed during physical education classes. Study participants were students in a fourth-grade elementary school class that had a student with disability. The researcher and the Physical Education teacher elaborated the planning program of an adapted physical activity with the use of videogames. The classes were recorded in a log book and group interviews were conducted at the end of each class. The results showed that the classes were nice, fun and interesting experiences. The study concluded that the program was successful.