Planejamento e síntese de novo candidato a fármaco útil para o tratamento de tumores sólidos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Arvore dos sonhos: uma metodologia de planejamento participativo

O presente trabalho tem como objetivo desenvolver e avaliar a aplicação da oficina de futuro “Árvore dos sonhos” com os alunos de uma escola estadual, localizada em um bairro periférico na cidade de Botucatu, e identificar os temas geradores, as necessidades e as motivações sobre o aprendizado na escola, para o desenvolvimento de propostas de um projeto interdisciplinar relacionado à melhoria do ambiente escolar. Para Doll(1997) um currículo construtivo é aquele que emerge da ação e interação dos participantes. Hernandez (1998) afirmou que o papel do currículo integrado é educar para compreender e que interpretar é manifestar explicitamente a compreensão. Professores e coordenadores, geralmente, tem dificuldade em planejar e realizar trabalhos articulados, com isto poucos estudantes são capazes de vislumbrar a integração dos conteúdos vistos nas diferentes disciplinas, esta situação é constatada na realidade de muitas escolas brasileiras, que vêem buscando alternativas que contribuam para superar alguns dos obstáculos relacionados ao processo de ensino e de aprendizado. A atividade de construção da árvore dos sonhos foi proposta ao Ensino Médio para sensibilizar os alunos, para que pudessem se expressar, através de uma atividade interativa envolvendo a participação coletiva da turma. Cada sala foi responsável pela elaboração da idéia, construção, finalização, exposição dos sonhos e preservação da sua árvore dentro da sala de aula. Em algumas salas os temas geraram polêmicas e indignações diante da situação atual na escola, em outras não houve muito envolvimento dos alunos em virtude do sentimento de impotência, desmotivação e fracasso diante dos problemas dificultando a emergência de processos de mobilização que promovam em mudanças. Os sonhos e propostas escolhidos pelos alunos foram levados ao HTPC, para que em conjunto com o corpo docente, coordenadores da escola e a DE (Diretoria ...

Planejamento, síntese e avaliação da capacidade de doação de óxido nítrico de novos derivados antiinflamatóios

A formação do trombo arterial, composto predominantemente por plaquetas, se dá sob condições de estresse de cisalhamento elevado, nos locais de lesão aterosclerótica vascular e fluxo sanguíneo perturbado e tem como consequência diminuição ou obstrução do calibre dos vasos dos diferentes órgãos podendo levar a eventos isquêmicos. As doenças cardiovasculares são consideradas as principais causas de morte no mundo. Nesse contexto, estima-se que a aterosclerose/aterotrombose seja a causa primária de doença arterial coronariana e acidente vascular cerebral representado mais de 50% das causas de mortes em países ocidentais . É sabido que a aterosclerose, primeiro evento que predispõe à aterotrombose, é considerada um processo inflamatório crônico, e que a utilização de antiinflamatórios não esteroidais (AINEs) COX-1, melhor estabilizam a estrutura da placa ateromatosa impedindo o rompimento e a consequente formação do trombo. Neste contexto, no presente trabalho foram obtidos de novos candidatos a fármacos com propriedades doadoras de NO e antiagregantes plaquetárias, através da estratégia de hibridação molecular dos AINEs contendo uma subunidade doadora de óxido nítrico, representada pelos furoxanos, e espaçada por uma subunidade N-acil hidrazônica. Dessa forma, a inibição da síntese de tromboxanos associada à doação de óxido nítrico permitiu atuação nas plaquetas através de um mecanismo múltiplo de ação com fins de diminuição da agregação plaquetária. Os produtos intermediários e finais apresentaram bons rendimentos e foram caracterizados por técnicas analíticas as quais predisseram que as estruturas propostas foram obtidas. Todos os compostos se como doadores de óxido nítrico. Os compostos 1a e 3a apresentaram atividade analgésica superior a dipirona, utilizada como controle. No ensaio de agregação plaquetária ―in vitro‖... (Resumo completo, clicar acesso eletrônico abaixo)

Zoneamento acústico urbano e mapeamento de níveis sonoros na zona central de Rio Claro (SP): diretrizes para o gerenciamento do ruído integrado ao planejamento ambiental urbano

Considering the growing degradation of the urban environmental quality resulting from the progressive sound pollution increase, as well as the consequent harmful effects about the human health, the present study had its central objective the argument and management tools implementation of the urban noise that can be integrated to the environmental planning in the city of Rio Claro (SP). Therefore, normative and bibliographical revisions were developed, that made feasible the directives of control argument and prevention of the urban noise, as well as the technical procedures of sound levels and evaluation’s definition and especially about the criteria applicable for the elaboration of an urban acoustic zoning methodology. Among the main results obtained detach: (1) the applicable legislation to the management of urban noise’s synthesis and argument; (2) the methodology of urban acoustic zoning development and (3) its implementation to determined areas of Rio Claro (SP) with the (4) respective cartography representation; (5) the mapping of sound levels in the central zone of Rio Claro (SP), (6) the obtaining and analysis of noise describers (LAeq, Lmáx, L10, L50, L90, Lmin and TNI) and the subsequent (7) acoustic maps elaboration for the main describers.

Experimentos de baixo custo para o ensino de eletrostática no nível fundamental

The experimentation in the teaching of physics has been extensively studied over the years because of its potential as a tool demonstration of physics phenomena studied in classroom. In such a perspective view of the action of apprentice student involving teaching future teachers of physics, under the Program PIBID CAPES, developed since 2009, seeks ways to improve the teaching of physics experiments using the theme chosen for the electrostatic work was . In this particular work, we report the development of the project in a State School located in the city of Rio Claro, in two rooms in the 9th grade in elementary school. It is planned with the activities of teaching physics at this level of education, look at how two different ways of displaying the contents of electrostatics in a playful way for elementary students and implement a library of experiments so that students can take the experiments to their homes

Análise de algoritmos computacionais utilizados em sistemas de planejamento de braquiterapia de alta taxa de dose: estudo comparativo com o Código MCNP-5C

In radiotherapy, computational systems are used for radiation dose determination in the treatment’s volume and radiometric parameters quality analysis of equipment and field irradiated. Due to the increasing technological advancement, several research has been performed in brachytherapy for different computational algorithms development which may be incorporated to treatment planning systems, providing greater accuracy and confidence in the dose calculation. Informatics and information technology fields undergo constant updating and refinement, allowing the use Monte Carlo Method to simulate brachytherapy source dose distribution. The methodology formalization employed to dosimetric analysis is based mainly in the American Association of Physicists in Medicine (AAPM) studies, by Task Group nº 43 (TG-43) and protocols aimed at dosimetry of these radiation sources types. This work aims to analyze the feasibility of using the MCNP-5C (Monte Carlo N-Particle) code to obtain radiometric parameters of brachytherapy sources and so to study the radiation dose variation in the treatment planning. Simulations were performed for the radiation dose variation in the source plan and determined the dosimetric parameters required by TG-43 formalism for the characterization of the two high dose rate iridium-192 sources. The calculated values were compared with the presents in the literature, which were obtained with different Monte Carlo simulations codes. The results showed excellent consistency with the compared codes, enhancing MCNP-5C code the capacity and viability in the sources dosimetry employed in HDR brachytherapy. The method employed may suggest a possible incorporation of this code in the treatment planning systems provided by manufactures together with the equipment, since besides reducing acquisition cost, it can also make the used computational routines more comprehensive, facilitating the brachytherapy ...

Método de Taguchi aplicado a um processo de corte por fusão de um tecido sintético

A company must have full knowledge and control of its operations so as to meet the market requirements and meet their production goals. Thus this paper uses the Taguchi method to extend the operational control of a cutting process by fusion of a synthetic fabric in the longitudinal direction. For process analysis and tracking of possible causes of the problem techniques of Production Engineering as the cause and effect diagram, also known as Ishikawa diagram, and design of experiments were used, the last one was applied to the design techniques of Taguchi. Finally the preparation method of understanding and design of experiment was due to the use of the software MINITAB v15 ®, which showed that the speed of rolling the fabric after cutting is crucial for controlling the entire operation

O ensino e a surpresa: experimentos surpreendentes e suas possibilidades no ensino de Física

Some experiments in Physics teaching have an amazing effect among the students, that is, generally be characterized by counteracting the initial expectations of students. This characteristic may contribute to the emergence of learning situations extremely promising. However, the privilege, by the teacher, the description of certain results shortens the involvement that the student could establish on teaching situations favor a more careful observation that can be done. We discuss in this paper, the that surprise may be manifested in the student on an experimental demonstration and its ability to mobilize the interest and curiosity of this student. We intend to observe the pedagogic value that represents the amazing effect such in situations of teaching and learning, particularly for the Teaching of Physics, as well as the possibilities for educational approaches.Through an extensive analysis of several authors who address about experimental learning activities, Epistemology of Science and Education, we found some results that lead us to understand some of the possibilities that the surprise element can propose. We describe a demonstration activity that we consider amazingly from our point of view and that was realized in a regular classroom in a of Rio Claro Public High School in the year of 2011

O uso de experimentos didáticos como ferramenta para o ensino de física nos anos iniciais da educação básica

When it comes to teaching physics in the early years of elementary school, the first question is: but there are opportunities to teach concepts to children of such complexity? This study sought to examine approaches and strategies to enter the Basic Education in Physics. To this end, we used low cost materials testing, taking as its starting point the work of Ferreira (1978) instrumentation for Teaching Physics, particularly with the theme electrostatics. The present study was made from the use of prototypes developed with the materials cited. Observations were made in the classroom looking for, from the records of teaching, analyzing the behavior of children and their arguments, possibilities for Physics Teaching this age group as well as some evidence of their cognitive development. In teaching discussions were held with students of the early years of elementary school involving conceptual and phenomenological aspects, adapting such knowledge at the level of logical and mathematical thinking that was still under development. The work shows that it is possible to work on electrostatic physical concepts with children belonging to the age group of nine to ten years. With the support of the group Pibid Physics city of Rio Claro, I realize my observations and practices at the Municipal School Marcelo Schmidt, which proved to be available and open for acceptance of this proposal

Diagnóstico ambiental do município de Ipeúna: subsídios para o planejamento do turismo

This study sought to address the tourism system in its various strands, compared to socioeconomic and environmental issues. Contextualizing the theme of sustainable tourism, or ecotourism, the reality of the city of Ipeúna, there is the incipient state of efforts in this activity because, predominantly, its territory is occupied by the monoculture of cane sugar and pastures, which damages the maintenance of vegetation fragments, as well as degrading areas that often could take a value tour. Through environmental planning, was intended to raise major issues of interface tourism / environment in order to seek alternatives to the implementation and development of tourism in Ipeúna. As a result, it presents an environmental diagnosis of the study area through which to assess the current status of tourist attractions in relation to environmental and socio-economic dynamics of the city.

Relações públicas e o planejamento estratégico nas instituições de ensino superior privadas

The society of the information brings with it a lot of changes day by day of the organizations, mainly for characterizing as a flexible society, in net and ruled in technological progress. The contemporary organizations are inserted in that reality and they need be maintained in markets more and more competitive. The Private Institutions of Higher education enter in this logic for they be organizations with lucrative ends that suffer strong influence of the external and internal atmosphere. To stand out, such Institutions need to count with a strategic administration, ruled in an own strategic planning for the branch in that acts. The professional of public relationships is shown capable to develop their main functions in such complex market. For so much it needs to participate in the global planning of the Private Institutions of Higher education, at the same time in that it develops it planning of the communication, intrinsic to the global strategic planning. This way, the present study treats of the professional's of Public Relationships possible contributions, ruled in theoretical data, inside of Private Institutions of Higher education in the Brazilian current scenery

Planejamento ambiental do distrito de Ameliópolis – Presidente Prudente - SP

The concern with the environmental planning has become important in Brazil recently. Until then, nature was conceived as a resource, because of the implementation of developmental policies that perdured to the 1970s, based on the expansion of the industrial complex, altogether hadn´t preoccupation by the federal government with the relationship between society and nature. During this period, after the threat of not receiving more international investment to finance large projects in the country, accompanied by pressure from civil society organizations, the federal government began to take some action related to the environment, such as the creation of federal agencies (IBAMA), application of environmental laws and decrees in order to create rules for the proper use of natural resources such as water, soil and air. From the decade of 1990 onwards the master plans have become a mandatory document for all municipalities in the country with a population over 20,000 inhabitants, ranging from health issues to the development of urban, rural and environmental planning. Thus, the environmental planning gained prominence in the political scene. Therefore, to achieve environmental planning is necessary to follow some social and environmental parameters, which for this survey, conducted in the District of Ameliópolis – Presidente Prudente... (Complete abstract click electronic access below)

Planejamento ambiental da bacia hidrográfica do córrego Embirí – UGRHI Pontal do Paranapanema – São Paulo: inventário e diagnóstico

This study aimed to contribute to the environmental planning of the watershed Embirí stream - UGRHI Pontal Paranapanema (belonging to the Paranapanema Management unit) in the cities of Presidente Prudente and Regente Feijó, São Paulo. This basin is located in the area of the Santo Anastácio river source, responsible for supplying water to about 30% of the population of Presidente Prudente. The methodological procedures based on Leal (1995) and Rodriguez et al. (2004), and the steps include inventory and diagnosis of the basin. We conducted extensive literature review, cartographic and documentary on the subject area of research, field work, preparation of thematic maps and summary chart of physical units and environmental use and land cover, participatory mapping of environmental risks, quality analysis of water. Most of the basin of the stream of twine had a high environmental fragility and the main problems found were lack of riparian vegetation, erosion, siltation of water bodies, irregular disposal of debris and the dumping of sewage. The results were summarized in the diagnosis and can identify the most important environmental impacts, environmental and spatial weaknesses of the legislation, and thus draw up proposals for action to the area that is substantially degraded

A utilização de modelos matemáticos para a otimização de processos

This dissertation has as main theme the discuss about how the use of mathematical models for process optimization. The current scenario of strong competition to conquer the consumer market necessitates the development of improvements to better performance of the process as a whole, is to reduce costs, increase efficiency or effectiveness. Thus, the use of methodologies to assist in this process is becoming increasingly viable. Methodologies developed in the past are being studied and improved. An example is the Desirability, the object of the present study, which was developed in the 80's and has been improved over time. To understand and study this methodology was applied to the desirability function in three instances, where it was used Design of Experiments (DOE), taken from scientific papers, using the Solver tool (Excel ®) and desirability (Minitab ®). Thus, in addition to studying the methodology, it was possible to compare the performance of tools used for optimization in different situations. From the results of this study, it was possible to validate the superiority of one of the models studied compared fairly

Planejamento ambiental da Bacia Hidrográfica do Córrego da Olga, UGRHI Pontal do Paranapanema – São Paulo: inventário e diagnóstico

This work, presented in order to obtain the environmental engeneer title, is to raise the current status of environmental conditions in the watershed of the stream of Olga and thus contribute to environmental planning for the recovery, conservation and preservation. To this end, we conducted literature surveys and survey of the characteristics of the watershed, analysis of water fron stream of Olga and making use of remote sensingand of the soil, environmental fragiityand spatialization of APPs in order to carry out further research on the environmental conditions of the basin, as well as inferences about possible causes of degradation of watershed.Most of the basin of the stream Olga had a high environmental fargility and the main problem was the lack of riparian vegetation is also considered the cause of environmental problems of the watershed.The results will be available to municipal governments in order to contribute to their planning and management of UGRHI the teh watershed pertence