254 resultados para Hemoglobina M
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Objective: To evaluate the efficacy of platelet-rich plasma regarding healing, pain and hemostasis after total knee arthroplasty, by means of a blinded randomized controlled and blinded clinical study. Methods: Forty patients who were going to undergo implantation of a total knee prosthesis were selected and randomized. In 20 of these patients, platelet-rich plasma was applied before the joint capsule was closed. The hemoglobin (mg/dL) and hematocrit (%) levels were assayed before the operation and 24 and 48hours afterwards. The Womac questionnaire and a verbal pain scale were applied and knee range of motion measurements were made up to the second postoperative month. The statistical analysis compared the results with the aim of determining whether there were any differences between the groups at each of the evaluation times. Results: The hemoglobin (mg/dL) and hematocrit (%) measurements made before the operation and 24 and 48hours afterwards did not show any significant differences between the groups (p > 0.05). The Womac questionnaire and the range of motion measured before the operation and up to the first two months also did not show any statistical differences between the groups (p > 0.05). The pain evaluation using the verbal scale showed that there was an advantage for the group that received platelet-rich plasma, 24hours, 48hours, one week, three weeks and two months after the operation (p < 0.05). Conclusions: In the manner in which the platelet-rich plasma was used, it was not shown to be effective for reducing bleeding or improving knee function after arthroplasty, in comparison with the controls. There was an advantage on the postoperative verbal pain scale.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Medicina Veterinária - FCAV
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Pós-graduação em Medicina Veterinária - FCAV
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Fundação de Apoio à Pesquisa do Estado de São Paulo (FAPESP)
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We investigated estradiol benzoate effects on oocytes/embryos recovery rate and the influence of this drug on the hematopoietic system. Twenty four bitches were divided in two groups, Group I, 12 females that received a single shot of estradiol benzoate, 0.2 mg/kg intramuscularly, between 2 and 7 days after the date of the last mismating or insemination and, Group II (control), 12 bitches that received 0.2 ml/kg of oily diluent, in corresponding dates. The bitches were ovary-hysterectomized and the uterus/oviduct were isolated and flushed with a PBS, heparin and polyvinyl alcohol solution. Oocytes and embryos were quantified and classified according to their stage of development. Blood counts were performed on M1 (before drug administration), M2 (15 days after drug administration) and M3 (40 days after drug administration). Pearson correlation coefficient was used to analyze the variable retrieval structures, while Fisher exact test was used for the analysis of embryonic viability. ANOVA was used to analyze repeated measurements and Tukey test for hematological parameters. All tests were performed at 5% significance level. The recovery rate of total structures in group I was lower (22.88%) than group II (65.85%). A lower embryo recovery (ratio 3: 52) rate and a greater number of degenerated structures (ratio 11: 1) were observed in group I. Hematological parameters showed significant difference in erythrocytes, hematocrit and hemoglobin concentrations 15 days after drug administration and difference in leukocytes concentration 40 days after using the medication in bitches of group I, however, at the end of the experiment all bitches had blood counts considered normal.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Ciência e Tecnologia Animal - FEIS
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Pós-graduação em Biociências - FCLAS
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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O trabalho que será aqui apresentado teve como finalidade reunir os resultados obtidos dentro do Laboratório de Organometálicos II em relação aos estudos realizados acerca da interação de íons metálicos com ligantes orgânicos naturais. Os dados apresentados foram obtidos pela autora deste trabalho, e também pelos professores Francisco Otávio Cintra Ferrarini, José Roberto Stefanelli Junior e pela aluna de Iniciação Científica Angélica Romão Carvalho. Hidrolisado proteico de soro de leite bovino e torta de linhaça foram os materiais obtidos, após uma série de operações que envolveram filtração com caulim, diálise, hidrólise enzimática, liofilização, etc., após as quais foram utilizados neste trabalho como ligantes de origem natural. Os metais de transição cobre, ferro, cobalto, zinco, paládio, platina e prata foram utilizados nas reações de complexação com os hidrolisados para obtenção de complexos metálicos, através do uso de diferentes rotas sintéticas (convencional, micro-ondas, hidrotérmica, difusão) e parâmetros experimentais (pH, solvente, natureza do precursor, etc.). A escolha dos íons metálicos baseou-se no interesse em preparar compostos que apresentassem ao mesmo tempo alta biodisponibilidade, baixa citotoxicidade e diversas aplicações biológicas. O uso do cobalto deveu-se à reconhecida propriedade que os micro-organismos do sistema digestório dos ruminantes apresenta de sintetizar a vitamina B12 e, portanto, os compostos desse metal podem ser usados em rações visando um melhor desenvolvimento do animal. O ferro, conhecidamente, é um importante metal para os seres humanos, estando presente na hemoglobina, sendo assim, também consiste em uma substância nutracêutica de relevado interesse. À propósito, cabe salientar que os compostos de ferro (III) obtidos nesse trabalho serão objeto de avaliação do uso como suplemento alimentar, em colaboração com o Departamento de...