Análise da expressão protéica de moléculas de adesão celular em melanomas cutâneos

Cutaneous melanoma is a malignancy caused by the uncontrolled proliferation of melanocytes. Has been increasing in incidence and mortality over the years. This type of tumor may arise in the skin or any other place where there was migration of neural crest cells. Melanocytes are located in the basal layer of the epidermis forming the epidermal melanin unit, involving a melanocyte to 36 keratinocytes. The proliferation of melanocytes depends on this relationship with the keratinocytes, gap junctions, E-cadherin and desmoglein. The basal membrane is responsible for promoting the integrity of the skin, their adhesion structures shown to be altered in several skin diseases. Some molecules that play the role of adherence in this membrane are the laminins, type IV collagen and type XVII and perlecan. Analysis of protein expression of cell adhesion molecules in melanoma by immunohistochemistry on tissue microarray (TMA). We selected paraffin blocks of patients who were diagnosed with cutaneous melanoma in the period 1995 to 2010, reaching a sample of 124 cases. All these have gone through review of preparation for subsequent histological analysis of tissue microarray (TMA). The protein expression will be analyzed by immunohistochemistry, using markers anti-laminin, anti-collagen type IV and type XVII and anti-perlecan. There was a predominance of female patients, Caucasians and southeastern Brazil. There were frequent in type of extensive superficial ulcers with Breslow depth greater than 4 mm, Clark level IV and mitotic index greater than 6 mitoses per cga. The patients, most of them were female with mean age of 57.13 years and Caucasian. The most frequent histological type was extensive superficial followed by acral lentiginous. Predominated cases very deep, with Breslow thickness greater than 4 mm, Clark IV, ulcerated and on average by 9 cga mitosis, leading to worse prognosis in this sample. It...(Complete abstract click electronic access below)

Diagnóstico turístico do município de Álvares Machado-SP

Este trabalho apresenta um estudo e levantamento dos potenciais turísticos da cidade de Álvares Machado-SP, bem como alguns benefícios que essa prática poderá trazer. Através desse levantamento, objetivamos propor alternativas para que o município aproveite melhor seus pontos turísticos, além de reforçar o sentimento dos munícipes pela cultura e história de formação da comuna. Dessa maneira, pautados pelo diagnóstico turístico, apresentamos na câmara dos vereadores a proposta da criação de uma Divisão de Turismo na prefeitura de Álvares Machado-SP, além do processo de tombamento histórico do conjunto de prédios da extinta FEPASA, onde será encaminhado para o CONDEPHAAT

Efeito da silibinina sobre o fator de transcrição nuclear-kB e produção de citocinas inflamatórias por células mononucleares de gestantes portadoras de pré-eclâmpsia

Pre-eclampsia (PE) is a complication of human pregnancy characterized by hypertension and proteinuria after 20 weeks of gestation. Its incidence varies from 5% to 7% of pregnancies and is a major cause of morbidity and maternal and fetal mortality. This is a multisystemic disease, with focus on vascular dysfunction and is closely related to the exacerbated activation of the immune system. In addition to increased activation of monocytes and granulocytes, there is an elevated production of proinflammatory cytokines in pregnant women with PE. The nuclear transcription factor-kB (NF-kB) is present in the cells of the immune system and is responsible for transcription of genes related to inflammation. Whereas the PE is associated with intense inflammatory response, the use of substances modulating the activity of NF-kB factor could be useful in alleviating the inflammation present in these patients. Silibinin is the main component of silymarin, a polyphenolic extract obtained from fruits and seeds of Sylibum marianum with potent hepatoprotective, anti-inflammatory and anti-fibrotic activities. The silibinin mechanism of action includes the ability to inhibit NF-kB activation and, consequently, its migration to the nucleus. The objective of this study was to assess whether silibinin modulates the activity of NF-kB and the production of inflammatory cytokines in mononuclear cells of patients with PE. We evaluated 34 pregnant women with PE, 20 normotensive pregnant women (GN) and 15 non-pregnant women (NG). Peripheral blood mononuclear cells (PBMC) were obtained from those groups of women and cultured in the presence or absence of silibinin (5 uM or 50 uM) and stimulated or not with lipopolysaccharide (LPS) for 18 h to obtain supernatant for determination of tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1β) by enzyme immunoassay (ELISA). The cells were...(Complete abstract click electronic access below)

A precarização do trabalho: migrantes nordestinos no município de Leme-SP : caminhos, estradas e sonhos

This paper aims to examine the genesis of migration to the city of Leme-SP, as well as the influence of the social matrix northeastern expansion and redevelopment through the territorialization of the migrant population, particularly workers from the state of Ceará, migration from the 1970s. This process is evidenced by the territorial division of labor, through the economic, political and cultural insecurity through the work of cutting sugar cane, the territoriality of culture and northeastern faith in the city, and becomes another object before the materiality in which occurs. In this aspect, through dialogue between the sciences and arts, it was possible to show the historical importance of the phenomenon of migration in the country, in different scales and relationship that encompasses everything and everyone

Os bolivianos e uma nova territorialidade na metrópole: o bairro do Brás

The flux of Bolivian migrants to the city of São Paulo had its beginning in the 1950 decade, following bilateral agreements between Brazil and Bolivia, and was intensified since the beginning of 1980 decade, when existed a necessity of manpower in the textile sector of the city. The migratory fluxes previously stemmed of the North and Northeast regions of the country become less intense, having then the entrance of migrants coming from neighboring countries, the so called South Cone. The Bolivians leave their country in the search for better life conditions and find in São Paulo the possibility to insert them in the biggest concentration of financial capital in the Latin America. The objective of this research is to analyze the arrival of the Bolivian migrants to the city, having its locus of analysis the Brás region and the reflection about the foreigners that influenced the modification of the structure, both territorial and cultural, of the district and how is the relation between the Bolivians and the habitants previously established there

Estudo e análise do risco e da viabilidade econômica do mercado cativo e do mercado livre de energia elétrica no terceiro ciclo tarifário

In 2004 two trading environment for contracts of purchase and of electricity energy were established, the Regulated Contracting Environment (RGE) and the Free Contracting Environment (FCE). In the first one, consumers can only buy their energy directly from local electricity distribution, and in the second one, consumers can choose their delivery, amount and type of energy that they will burn through bilateral contracts. Thus, before deciding to migrate to the FCE, it is necessary understanding the rules of marketing, the risk involved and the economic viability of the two markets so can determine which environment has more benefits to the consumer. This paper aims to offer tools to support takeover decision of potentially free costumers, who have the option to migrate to market in order to evaluate the benefits and disadvantages of each market. This paper has also considered the new rules of the third rate cycle, where consumers can opt for green tax. The methodology presented is based on calculations of spending with energy and the risk of flag in captive market and free market in one year

Brasil, Japão: centenário de interação cultural e sexual

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Rafard (SP) e a cultura da cana-de-açúcar: considerações sobre a urbanização e as relações sociais

We intend to expose this paper a brief review about the social factors that include the capitalist system. Having the city of Rafard as our focus of study, we are going to analyze how agribusiness and migration have great political significance in this small town, and still are determining factors for socio-cultural training of its citizens, as well the formation and economic development of their own city. We are going to observe how a town with only 8.599 inhabitants is subjected to the laws dictated by capital through the interference of a large sugarcane agro industrial production unit present in its territory

Dynamic behavior, stochasticity and enviromental heterogeneity in Tribolium castaneum

In this study we analyzed the influence of demographic parameters on the population dynamics of Tribolium castaneum, combining empiricism and population theory to analyze the different effects of environmental heterogeneity, by employing Ricker models, designed to study a two-patch system taking into account deterministic and stochastic analysis. Results were expressed by bifurcation diagrams and stochastic simulations. Dynamic equilibrium was widely investigated with results suggesting specific parametric spaces in response to environmental heterogeneity and migration. Population equilibrium patterns, synchrony and persistence in T. castaneum were discussed

Território migratório - contigüidade socioterritorial de terras distintas: os Dekasseguis e a busca pela reterritorialização

This paper analyzes the new trends of Brazilian migration to Japan, more specifically in the process of redefining its territoriality on the political and administrative Japanese territory. This migration, known as Dekassegui movement, is based on the flow of Brazilians of Japanese descent in this country. The working part of a periodization of the movement, considering the political and economic situations of countries and account for aspects of the difficult adjustment of the pioneers, the change the temporal expectation of return and search for repossession of these immigrants in their most recent time frame After more than 27 years of migration is still common difficulties in the integrating the Brazilian front of Japanese society, and it is in this context, however, that migration projects take new directions, new meanings are created networks, strengthens relationships, change and so plans to build a new interaction with the territory. To understand this process, we consider as a theoretical analysis and territorial consolidation of field research in Japan, through questionnaires, to identify the processes of social integration of immigrants

A construção social da identidade territorial em dois assentamentos humanos na cidade de Huánuco - Peru

O trabalho analisa como se estabelece o processo de construção social de uma identidade territorial em dois assentamentos humanos na cidade de Huánuco, Peru. Os processos de assentamento se configuram por movimentos migratórios autônomos, por processo de migração forçada (refugiados), ou por políticas públicas específicas de assentamentos humanos, seja por instrumentos de reforma agrária e ou por reordenamento territorial, bem como por iniciativas concretas construídas pelos sujeitos a partir de sua atuação em movimentos sociais. Estes últimos se estabelecem de forma mais acentuada na América Latina, no campo e na cidade, por meio dos movimentos sociais de luta pela terra; no Brasil, em particular no campo, o MST se constitui em um grande protagonista, assim como em lutas por moradia também se encontra um movimento mais articulado denominado Movimento dos Sem Teto. Buscou-se compreender melhor como esses movimentos ocorrem no Peru e tendo como base empírica o município de Huánuco. Destaca-se que esse processo de reorganização espacial dos sujeitos gera dúvidas quanto a se constituir em um território de emancipação, de constituição de liberdade organizativa e de gestão, com capacidade de se transformar em elemento de alteridade, ou simplesmente de subordinação, confinamento, não permitindo a constituição de uma comunidade livre e autônoma. Diante destas questões exige-se uma reflexão sobre o processo de construção social de uma identidade territorial, como forma de entender as dinâmicas de apropriação territorial que se efetiva por comunidades nesta nova espacialidade ocupada e vivenciada, delimitando claramente se esta espacialidade constitui um território per si ou em si. Para Sartre o per si é o fazer conscientemente, construindo para si significação sobre sua existência prática e cotidiana no mundo... (Resumo completo, clicar acesso eletrônico abaixo)

A produção do espaço em cidades pequenas: o caso de Emilianópolis

In this paper we analyze some factors of urban life in small towns, among which we can highlight the political, economic and social, more specifically in the city of Emilianópolis, and its great dependence on other cities. The number of small towns has grown in recent years and this study shows is of great importance for understanding the differences that exist between them and the larger cities. Where Emilianópolis, having its location next to a city average (Presidente Prudente), we realize that its existence depends largely on the proximity of that with a bigger city. The study looked at the origin of the city, its spatial structure, its insertion into the urban network and the degree of dependence with other cities, notably Presidente Prudente, which generates a steady stream of people moving from Emilianópolis to study, work, leisure, between others, besides the permanent migration, which often makes life easier for those residents. With this study, we intend to demonstrate how Emilianópolis is inserted into the urban network, how is its interaction with other cities and how they live their inhabitants

Narrativa e experiência: percepções, práticas culturais e memórias de pessoas migrantes

Based in the contact with adults with little education that living in two suburbs of Rio Claro-SP, whose population is largely coming from other states, there were some questions, including: What are reasons for migration are pointed in the narratives of adults little schooling participants EJA classes? So, in the first moment of this research, we present some data collected through a questionnaire applied to students of EJA, we taking information about the state and county of origin of each student. In the second stage methodology was used Oral History pointed questions about the motives of migration reported by subjects who migrated, access and search for education and practice in reading and writing. It was also realized, an activity imagery (or walker interview) with the student, highlighting elements of the landscape of the neighborhood that brings memory's birthplace. Therefore, we present here the stories of women who had migratory experience

Neoplasias mamárias de cadelas: expressão gênica e proteica da via Wnt/b-catenina, sua associação com a transição epitélio-mesênquima e prognóstico

Pós-graduação em Medicina Veterinária - FCAV