Busca de novos alvos terapêuticos no tratamento de câncer de pulmão utilizando ferramentas de biologia de sistemas

A quimioterapia e uma das formas de tratamentos para o câncer, cujo processo e pela aplicação de medicamentos que alteram a síntese de DNA, interrompendo a divisão celular. No caso do câncer de pulmão, a difículdade está no fato de que as células cancerígenas criam quimiorresistência após um determinado período de tempo. Se o indivíduo desenvolver o câncer de pulmão novamente, deverá ser aplicado outro quimioterápico no paciente, e assim por diante. Nos tratamentos atuais são utilizados combinações de drogas para contornar o problema da quimiorresistência. Este trabalho utilizou a biologia de sistemas para encontrar novos alvos protéicos para auxiliar no desenvolvimento de novos quimioterápicos para o tratamento do câncer de pulmão. Foi construída uma rede baseada nos alvos protéicos já conhecidos. A rede foi expandida com o intuito de buscar quais são as proteínas que interagem com os alvos protéicos á conhecidos. Após a expansão, foram utilizadas análises de centralidades para evidenciar as proteínas mais importantes na rede, e correlacionamos com informação de expressão gênica para verificar se as proteínas mais importantes do ponto de vista topológico estão diferencialmente sub ou super expressas. A análise de centralidade junto a mostra dos dados de expressão gênica convergiu para um bom resultado, foi possível evidenciar algumas proteínas que podem ser utilizadas como novos alvos quimioterápicos

Identidade e estudos organizacionais: em direção a um novo paradigma?

This paper aimes to contribute to the analyzes of Caldas and Wood Jr (1997) concerning to the concept of identity. That concept has been developed in Organization Studies under the propositions of Albert and Whetten (1985). In that way, identity concept has been defined by the following characteristics: centrality, distinctiveness and continuity. Nevertheless, a new paradigm has been emerging within social science. In this paper, we present a synthesis on how the concept of identity has been discussed in Social Psychology and Cultural Studies. For both theoretical perspectives, the ideas of centrality and durability are put into doubt, as identity is seen as dynamic and fragmentary. Besides that, we intend to show how the new paradigm is getting formed within Organizational Studies, especially considering international context. Considering that the emerging organizational ideas concerning identity show proximity with those proposed by Social Psychology and Cultural Studies, we raise possible questions that the new paradigm will have to face.

Dirigiu-se para a sede social da Elite Flor da Liberdade e ofereceu um banquete aos visitantes: sobre a variação de proposições em complementos verbais

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Clíticos e preposições: a norma e o normal em jornais paulistas (1900 a 1915)

Based on the assertions of the Theory of Linguistic Variation and Change, this paper proposes a discussion about the possible action of linguistic norms over two variable phenomena in Brazilian Portuguese: the position of clitic pronouns associated with a single verb, and the use of prepositions with verbal complements indicating a ?goal/recipient?. By the analysis of data from the newspapers from São Paulo and Rio Claro between (the years of) 1900 and 1915, we intend to describe each phenomenon; compare these descriptions and evaluate the role played by the standard and the common usage which is (already) perceptible in the ?paulistas? continuous published pages of that period.

Cronopoiese e cronotrofia na história em quadrinhos

This article proposes a reflection on the “continuities of the process” in narratives, defined by the closure of the space and by the waiting in time (chronopoiesis), as well as on the “halts of the process” in narratives, defined by the opening of the space and by the repose in time (chronotrophy). In Claude Zilberberg?s proposal about the missive making (le faire missif ), it means, the profound making that governs the becoming of the narratives, temporality and spatiality are related to the categories of closure and opening. The terms chronopoiesis and chronotrophy, established by Zilberberg from the Greek stems, have etymologically in common the stem “krónos”, the time. The first term is added to “poiesis”, “creation”; the second comes together with “trophê”, the “feeding”, the “development”. The remissive making, that carries the “continuities of the process”, is chronopoietic (the expectant temporality, which creates the waiting time), and spatially closed. On the other hand, the emissive making, which carries the “halts of the process”, is chronotrophic (the “originating” temporality, because it is “fed”, creating the passing time) and spatially open. Our reflection on chronopoiesis and chronotrophy aims at verifying if these temporal operations of the missivity necessarily correspond to spatial closures and openings, respectively, as the Zilberberg’s model proposes, in verbo-visual narratives, specifically in comics.

Metalinguagem semiótica: empréstimos e redefinições

This paper deals with the issue of terminology and conceptualization in the construction of the semiotic metalanguage. The starting point of this discussion is the scientific thought of C. S. Pierce, R. Bastide and É. Benveniste, who understand that the creation of a new science requires a new and precise terminology. This position is relativized and magnified by the point of view of A. J. Greimas, who defends the centrality of the conceptualization rather than the formalization and the terminological production. Thus, this study proposes and analyses two types of metalinguistic elaboration based on the dialogue with previous theories and disciplines: the borrowing and the redefining.

As políticas curriculares da educação profissional técnica de nível médio: desafios/correlações do princípio de competência da Resolução CNE/CEB 4/99

This paper proposes some reflections from activities developped in the context of a research supported by FAPESP called “As políticas de educação profissional e tecnológica no Brasil pós LDB 9394/96”. Our purpose is to analyze the federal legislation of professional and technological education, by enphasizing its impacts in technical schools of São Paulo (Brazil).

O caso comitativo

Comitative is a semantic case not much studied. Traditional grammar includes it sometimes as Indirect Object, sometimes as Adverbial Adjunct of Company. In this paper, we show that it is a nuclear element, therefore it is a Complement not an Adjunct; in other words, being a deep semantic case, it constitutes an Argument selected by the verb in the sentence organization.

Subjetividade no processo de subordinação substantiva: a expressão da evidencialidade

In this paper, we intend to reflect on the subordination process based on a functionalist-cognitive approach. For this, we analyze syntactic constructions in which the main clause predicator is a speech act verb, a mental activity verb or a perception verb. One of the pragmatic functions of these constructions is to express evidentiality, which is basically the indication of the information source contained in a sentence. Evidentiality allows the Speaker to manage information in order to preserve his/her face and also allows the Addresser to assess the reliability of this information. We take the evidentiality expression as a functionality of the subordination process in order to rethink the teaching of syntax as a tool for an effective development of students’ communicative abilities.

Notas sobre os historiadores e suas fontes

The aim of this text is to discuss the different meanings attributed to notions of historical sources and documents from the nineteenth century, when history was constituted as a discipline. It is important to point out the centrality of this issue to the different conceptions about the production of knowledge in this field.

O apoio institucional como uma das faces da função apoio no Núcleo de Apoio à Saúde da Família (NASF): para além das diretrizes

The aim of this study was to add to the debate about Family Health Support Centers (FHSCs), starting from reflections about the support function. Support is generally presented, in official documents from the Ministry of Health and in academic-scientific publications, accompanied by descriptors that characterize it. Differences in terminology are commonly encountered: “institutional support”, “managerial support”, “matrix support” and so on. With regard to FHSCs, published papers have highlighted the central role played by matrix support. However, we pose the question: what are the faces that the support function has been taking on in implementing such programs? To reflect on this and other issues, we developed a study of qualitative nature within a FHSC team in Paraná, outside of the state capital, using the methodological tools of participant observation, semi-structured interviews and discussion groups. We sought to demonstrate that the dynamics of the support function in FHSCs make it possible for both matrix support and institutional support to emerge.

O vestibular da UNESP: sobre acesso à educação superior e o currículo de geografia na educação básica (2006-2012)

Pós-graduação em Geografia - IGCE

A linguagem do consenso nos marcos da regressão cultural: o fim da consciência e a construção do neocontratualismo de Jürgen Habermas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Esquerda pós-moderna e emancipação social: uma resposta ao Fórum Social Mundial

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Deslocamentos pendulares, consumo e shopping centers em cidades médias paulistas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)