218 resultados para Transformação de fases
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O objetivo geral deste trabalho foi o de investigar os sentidos e concepções sobre a infância e a adolescência na sociedade atual e suas implicações no âmbito escolar. Buscamos entender os porquês que esse processo vem ocorrendo tendo como pressuposto sua associação com os modos de tutela e a consequente autonomia e independência precoce que crianças e adolescentes parecem estar adquirindo na sociedade atual. Ao examinar as concepções de infância e adolescência de crianças e adolescentes, buscamos investigar os limites e a autonomia das crianças e dos adolescentes, caracterizando os modos de tutela que os pais empregam na relação com seus filhos e analisar as implicações destas concepções no âmbito escolar
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Experimental models are necessary to elucidate pathophysiological mechanisms not yet understood in humans. To evaluate the repercussions of the diabetes, considering two methodologies, on the pregnancy of Wistar rats and on the development of their offspring. In the 1st induction, female offspring were distributed into two experimental groups: Group streptozotocin (STZ, n=67): received the β-cytotoxic agent (100mg STZ/kg body weight - sc) on the 1st day of the life; and Non-diabetic Group (ND, n=14): received the vehicle in a similar time period. In the adult life, the animals were mated. After a positive diagnosis of pregnancy (0), female rats from group STZ presenting with lower glycemia than 120 mg/dL received more 20 mg STZ/kg (ip) at day 7 of pregnancy (2nd induction). The female rats with glycemia higher than 120mg/dL were discarded because they reproduced results already found in the literature. In the mornings of days 0, 7, 14 and 21 of the pregnancy glycemia was determined. At day 21 of pregnancy (at term), the female rats were anesthetized and killed for maternal reproductive performance and fetal development analysis. The data were analyzed using Student-Newman-Keuls, Chi-square and Zero-inflated Poisson (ZIP) Tests (p<0.05). STZ rats presented with increased rates of pre (STZ=22.0%; ND=5.1%) and post-implantation losses (STZ=26.1%; ND=5.7%), reduced rates of fetuses with appropriate weight for gestational age (STZ=66%; ND=93%) and reduced degree of development (ossification sites). Conclusion: Mild diabetes led a negative impact on maternal reproductive performance and caused intrauterine growth restriction and impaired fetal development
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The research addresses the need for detailed geological and geotechnical investigations in pipeline’s design, given the diversity of geological units crossed by these works along its layout, which often extends for hundreds of miles. For its large size, this type of work often goes through different states and regions with very different characteristics in terms of topography, vegetation, geology and geotechnical conditions. For a better use of these investigations in order to avoid unnecessary costs and inefficient results, some authors recommend that steps be taken to study, seeking a progressive detail of the pipeline’s implantation area. The main objective of the study is to describe, analyze and correlate the proposals for geological and geotechnical’s investigation recommended by the authors selected. Nogueira Junior & Marques (1998) suggest that for better effectiveness of geological and geotechnical investigations associated with the deployment of pipelines, different research methods are applied sequentially in five major stages of the building. Rocha et al (2008) recommend that, for the pipeline’s implantation using horizontal directional drilling, investigations are performed in three phases of study, to be developed in coordination with the project stages. For Gelinas & Mathy (2004), when time and budget constraints permit, geotechnical investigations for directional drilling projects for pipelines must be made in four sequential phases. Heinz (2008) suggests that the geotechnical investigations for pipeline’s implantation using horizontal directional drilling at crossings of water bodies are carried out in three successive stages. By the development of research, we could see that all the different proposals recommend studies in sequential phases, starting from a more general scale for a more specific, seeking a progressive understanding of the geological model of the area where you intend to deploy the pipeline
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Aiming to reduce the cost of electrocatalysts and a greater resistance to CO poisoning this work was to study the adsorption and oxidation of carbon monoxide on ordered intermetallic phases AuIn, AuSb2, AuSn, PdSb and PdSn using voltammetric techniques in alkaline electrolyte solution. The results suggest that the AuSn and PdSn intermetallics has some form of resistance to CO poisoning. It is assumed that this behavior is a result of electronic effect and the effect of the third body has been achieved by adding a second metal to Au and Pd. However, further studies should be conducted to confirm this hypothesis as to test these materials as electrocatalysts in the reaction of oxidation of fuels
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The Organizational Culture has been in the spotlight in the last 25 years, studies show the influence of the culture in the production processes and in the strategy decisions of the companies. Changes in the organizational culture is necessary in key-moments of the corporation and this transformation moment influences directly the personal life and the professional life of the employees. The objective of this monograph is to verify the application of the “Transformation Program”, which is the changing program of a technology enterprise, and to attest the acceptation degree and the knowledge of the employees about the program, as well the main difficulties found by the company while implementing the project. Using a quantitative pool, the acceptation degree, the knowledge of the employees and their engagement with the Transformation Program were analyzed by checking the favorability of the answers and comparing the percentage of the whole company and its locations, besides with the results an understanding change curve was created, it identifies the stage that he employees are during the changing process. An interview with the actual and the previous program officers and two project managers was done, in order to identify their alignment with the theory and their perception about the difficulties found while applying the program. It was noted that the employees have heard about the Transformation Program and the majority is in the exploration phase of the understanding change curve, although it is necessary an special attention with the leaders, because the researches showed that the leaders are acting like a bottleneck in the communications by keeping the information that should be shared
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The Environmental Protection Areas (EPA) are a type of sustainable use conservation unit, therefore its territory have public and private areas. To establish and reorganize the use of EPA’s territory, aiming the environment conservation along with human actions, it is necessary a management plan that should be conducted within five years from the date of its creation. The EPA Botucatu, established in 1983, does not have its management plan completed until the present day. The consequences of lack of organization about the use and occupation of its territory can be observed in a comparative study of territorial classification between the years 1985 and 2010, which was the objective of this study. As a result, it could be observed the decrease of the remaining fragments and intense fragmentation of them, pointing to the need for projects that aim the restoration, conservation and connectivity between these fragments and the subsequent application
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Neste artigo descrevemos o comportamento de orações subjetivas e objetivas diretas nas fases arcaica (séculos XIII a XV) e moderna (séculos XVI e XVII) do português. Adotamos o quadro teórico da gramaticalização e dessentencialização de orações e discutimos resultados para os parâmetros tipo semântico do predicado matriz, unidade semântico funcional representada pela oração encaixada e formato da oração encaixada. Observamos, ao longo das sincronias, correlações sistemáticas entre os parâmetros investigados para os dois tipos oracionais. Orações subjetivas apresentam menor variedade de padrões do que orações completivas objetivas, principal diferença a interferir em suas estabilidades sintático-semânticas nos períodos investigados.
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Durante a transformação maligna dos melanócitos, padrões de metilação do DNA encontram-se alterados, afetando a expressão gênica. As citosinas metiladas (5mC) podem ser hidroxiladas pelas dioxigenases dependentes de 2-oxoglutarato e Fe(II), Tet1, 2 e 3, resultando na formação de 5-hidroximetilcitosina (5hmC) (Globisch et al., 2010; Ko et al., 2010). A 5hmC pode agir tanto como um produto intermediário na desmetilação ativa do DNA quanto na desmetilação passiva ao longo de sucessivas replicações, o que pode contribuir com a dinâmica da metilação do DNA (Tahiliani et al., 2009). Além disso, demonstrou-se que Tet1 e Tet2 são expressas em células tronco embrionárias (Ito et al., 2010) e que 5hmC desempenha importante papel na manutenção e diferenciação destas células (Koh et al., 2011). No entanto, o papel da 5hmC e das proteínas Tet tanto na fisiologia normal quanto em doenças como o câncer ainda não está claro. Utilizando um modelo linear de progressão do melanoma, observamos aumento na expressão gênica de Tet1 nas linhagens celulares correspondendo a melanócitos pré-malignos (4C) e células de melanoma não metastático (4C11-), comparado a melanócitos não tumorigênicos (melan-a) e células de melanoma metastático (4C11+). Em relação à expressão proteica, há um aumento da expressão de Tet1 nas linhagens 4C e 4C11+, o que pode ser relacionado às fases de transição epitélio-mesênquima (EMT) e mesênquima-epitélio (MET), respectivamente. Além disso, constatamos aumento na expressão gênica e proteica de Tet2 na linhagem metastática 4C11+, o que pode indicar diferenças funcionais entre as proteínas Tet1 e Tet2. Também verificamos aumento significativo do conteúdo de 5hmC na linhagem 4C11+, o que se correlaciona com maior expressão gênica e proteica de Tet2. Por fim, linhagens humanas de melanoma metastático menos agressivas apresentaram aumento significativo na expressão dos genes TET1 ...
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Pós-graduação em Ciência dos Materiais - FEIS
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Pós-graduação em Zootecnia - FCAV
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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No presente trabalho analiso uma experiência piloto de implementação de um projeto de parceria de teletandem português e español, entre a UNESP campus de Assis/São Paulo/Brasil e a UTU – Salto – Uruguay. Nesse contexto, saliento a trajetória de uma professora uruguaia e sua inserção na utilização das TICs no processo de ensino-aprendizagem de LE.