224 resultados para Citotoxidade de mediação celular


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The use of pesticides in Brazil has intensified over the years. And since 2009 it was ranked as the largest market for pesticides worldwide. The consequential diffuse contamination of the environment is therefore due to the increasing number of chemicals of different classes, origins and modes of action. Little is known about the action of pesticides on human health in situations of co-exposure. Possible toxic effects are not restricted to agricultural and industrial workers, but also the general population that may be exposed continuously to its residues in food and water. Although these pesticides are mostly present in the environment at low doses, it must be considered that possible cumulative or synergistic effects may occur when there are concurrent or sustained exposure for two or more of these agents, which can lead to late manifestation of subclinical damages, sometimes irreversible. Thus, the specific objective of this study was to assess the effect of carcinogenesis promotion of a mixture of pesticides at low doses and analyze the phenomena of cell proliferation and apoptosis in rat liver. A total of 50 male Lewis rats was separated into 5 groups for 8 weeks in a medium term hepatocarcinogenesis model. The three different classes of pesticides (dieldrin, dicofol, endosulfan, dichlorvos and permethrin), whose residues were detected by ANVISA during the period from 2001 to 2005 in tomatoes cultures, were added to the feed of rats initiated to hepatocarcinogenesis with diethylnitrosamine (DEN- 200mg/kg ip). We used two different mixtures, one with no toxic effects at doses (MEX1) referring to the NOEL (no-observed-effect level) and another at doses LOEL / LEL / LOAEL (Lowest-observed-effect level / Lowest-effect level / Lowest -observed-adverse-effect level), to the installation of adverse effects (MEX2), derived from chronic studies. All animals ...(Complete abstract click electronic access below)

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Articular cartilage is the structure that coats the bone ends in regions where two bones are articulated, allowing movement. It has inefficient intrinsic and extrinsic mechanisms of repair, usually resulting in fibrocartilage formation after injury. Such repair have lower strength, stiffness and usability features when compared to hyaline cartilage. The mesenchymal stem cells have the potential to regenerate tissue without the production of scar, and because of this feature it is well studied. But to have its maximum chondrogenic potential, it is necessary to use scaffolds and growth factors. Biomaterials play the role of scaffold for the cells allowing them to become attached, grow and produce extracellular matrix, leading to formation of repair with hyaline cartilage. In this sense, the purpose of this study is to provide information on the various studies using cell therapy and / or biomaterials to produce hyaline cartilage

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Nos últimos anos, as pesquisas com células-tronco têm despertado um grande interesse nos meios de comunicação, levando a população a encarar esse novo conhecimento científico como sendo um método promissor para a cura de inúmeras doenças até agora, tidas como incuráveis. Deste modo, mostra-se fundamental que o ensino de Biologia se volte para o desenvolvimento de competências que permitam ao aluno entender, discutir, questionar, analisar, adquirir um posicionamento crítico diante das informações postas e fazendo uso dos conhecimentos adquiridos, servir como multiplicadores do conhecimento científico. Este trabalho tem como objetivo central a produção de um material didático contendo informações a respeito das células-tronco, quanto aos tipos, características, classificações, métodos de coleta e as terapias desenvolvidas no Brasil. Informações estas que servem como auxílio para professores de Ciências e Biologia, na compreensão e atualização perante as inovações científicas relacionadas às células-tronco. O capítulo 6 vem como uma sugestão de atividades possíveis a serem desenvolvidas a partir desse tema. Apresenta ainda um CD-ROM contendo uma síntese do assunto proposto a servir como suporte no preparo de aulas didáticas relacionadas ao tema

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em Educação Escolar - FCLAR

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Este texto tem por objetivo apresentar as representações do mundo do trabalho dos alunos do Ensino Médio, da Escola Estadual Prof. Dr. João Deoclécio da Silva Ramos, Distrito de Talhado, São José do Rio Preto (SP), através do uso de mídias virtuais, especificamente o Blog de Aula - Mutirão de Sociologia (www.mutiraodesociologia.com.br). Compreender as representações de mundo trabalho possibilita aos alunos pensar em uma profissão a qual se identifiquem, além de estimular a reflexão enquanto futuros profissionais. As mídias virtuais, especialmente os blogs, possibilitam aos alunos expressar seus modos de viver e pensar o mundo do trabalho. No contexto da cidade de Rio Preto, é especialmente relevante aquelas representações do mundo do trabalho rural, de modo que este projeto vem a colaborar na elaboração de pesquisas interessadas na descrição e compreensão de processos que envolvem relações entre trabalho, educação e mundo rural.

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Pós-graduação em Educação Escolar - FCLAR

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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The paper talks about the education of persons with disabilities severe mental retardation based on the idea of Reuven Feuerstein mediation. The collected data were analysed mainly under the focus quantitative, allowing extraction of details of everyday life investigated. Aims to describe and analyze the implementation process their educational, focusing on teaching strategies used by Special Education teachers in the Araraquara’s city. In addition, seeks to address the educational process of a population slightly investigated by uniting two strands of thread in an innovative way: the Theory of Structural Cognitive Modifiability (SCM) and Reuven Feuerstein education of students with severe cognitive impairment. The methodology initiated by the establishment of the teacher’s profile, their mapping and location. Data collection was achieved through three instruments: interviews with teachers, observation protocol and field diary for registration. Our results describe the work of a teacher, showing their practice, and enlist the pedagogical strategies used, mainly those related to the criteria medication. According to the Theory of Structural Cognitive Modifiability (SCM) and the idea of Mediated Learning Experience (MLE), the teacher acts as mediator, interposing themselves between stimuli the environment and the student. The work of the teacher observed indicates that the environment and the student. The work of the teacher observed indicates that she exerts her functions in teaching using pedagogical strategies which are found in her heart, precepts essential to mediation. This shows it is possible to associate the ideas of Feuerstein practices aimed at teaching students with severe mental disabilities.