224 resultados para Citotoxidade de mediação celular


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Pós-graduação em Serviço Social - FCHS

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O livro Gestão, mediação e uso da informação vai ao encontro dos estudos teóricos e metodológicos de objetos e fenômenos que envolvem a gestão, a mediação, uso e apropriação da informação em distintos ambientes

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The main feature of pulmonary emphysema is airflow obstruction resulting from the destruction of the alveolar walls distal to the terminal bronchioles. Existing clinical approaches have improved and extended the quality of life of emphysema patients. However, no treatment currently exists that can change the disease course and cure the patient. The different therapeutic approaches that are available aim to increase survival and/or enhance the quality of life of emphysema patients. In this context, cell therapy is a promising therapeutic approach with great potential for degenerative pulmonary diseases. In this protocol proposition, all patients will be submitted to laboratory tests, such as evaluation of heart and lung function and routine examinations. Stem cells will be harvested by means of 10 punctures on each anterior iliac crest, collecting a total volume of 200 mL bone marrow. After preparation, separation, counting and labeling (optional) of the mononuclear cells, the patients will receive an intravenous infusion from the pool of Bone Marrow Mononuclear Cells (BMMC). This article proposes a rational and safe clinical cellular therapy protocol which has the potential for developing new projects and can serve as a methodological reference for formulating clinical application protocols related to the use of cellular therapy in COPD. This study protocol was submitted and approved by the Brazilian National Committee of Ethics in Research (CONEP - Brazil) registration number 14764. It is also registered in ClinicalTrials.gov (NCT01110252). (c) 2013 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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The oral cancer model in hamsters shows many simílarities with developmental oral cancer in humans. The proliferating capacity is one the most characteristics of neoplásica ce/Is and detection of these ce/Is allow us, throughout of its counting, to achieve an estimated tumour growing index, with a consequent repercussion about prognostic and in the treatment of those lesions. 40 golden Syrian hamsters, both genders, aged between two to six mouth and weight 150g in average were used. The left síde of tangue of each animal was painted for eight consecutive weeks, with a solution of DMBA. Tongues were removed, fixed in 10% buffered fonnal solution. The histological slides were stained by AgNOR technique and by PCNA and β-catenin immunohistochemical antibodies. Statistical analyzes were performed by ANOVA one-way test and Tukey test. We may conclude that an association between AgNOR and PCNA might indicate the higher proliferating activity of the analyzed celIs. The experimental carcinogenesis model in hamster tongue is an available methodology for immunohistochemistry study. And finally, PCNA and β-catenin immunohistochemical antibodies may be used to analyze possible premalignant areas in oral leukoplakia

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Information Science has for its object of study the general properties of information and analysis of their construction, communication and use processes. Organic information, one of the information types, is the one recorded in the archives, which can be split into two distinct groups based on users: current and permanent, used by administrators, historians/citizens, respectively. After defining the information behavior of each group, the articles directs the discussion to the mediation of information in the permanent archives. The interaction between user and information professionals through references services aiming the user needs is presented. In addition, the standards of archival description and the research instruments as tools to reference service are discussed. Moreover, it argues the importance of information technologies and the new possibilities for the promotion of organic information in permanent archives, especially concerning the information architecture of websites and the conversion of the DTD standards of archival descriptions.

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The life expectancy increase has been augmenting studies on human aging. Among these studies are those that address the interaction between the elderly and the information and communication technologies, which may facilitate the execution of daily activities by elderly people. Therefore, the goal of this article was to investigate the application of constructivist elements in computer courses offered to Universidade Aberta à Terceira Idade – UNATI – UNESP – Campus of Marília, contributing to the digital inclusion of this community. The constructivist elements focused on the role of the teacher as a mediator in the teaching-learning process. It was found that most of these elements are already being applied in this universe, but some changes need to be undertaken in order to expand the opportunities for education and to allow students to have more autonomy for information seeking and use in the web environment.

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Introduction: This paper presents preliminary results of the research project "Information access: actions and strategies of the Chamber of Deputies to meet 12.527/2011 Law”. Finally some considerations about the implementation of the Law within the Chamber of Deputies are presented. Objectives: Discuss the matter of public information access after the new Brazilian information access law and his relationship between the theories information policy, information regime and informational state. Methodology: Bibliographic research about several theoretical topics related to information access were raised, for example: the concept of information, information policy, informational state, information regime, electronic government and information asymmetry. Results: The preliminaries data shows a convergence of information policies from many countries, for example, Finland, Canada and South Africa, to a same point, which indicates an increase of transparency and a bigger active disclosure of information public. Conclusion: In Brazilian case, in the relationship between State and citizen, the new information access law means a materialization paradigm change or the concretization de other information regime. The sanction of this law can be interpreted as another step to increase the transparency and the affirmation of democratic relationship between State and society.

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This article discusses literary education from early childhood, understanding early childhood as the nursery period from zero to five years. This paper aims to make some observations about the teaching and learning of reading, their relationships with children’s literature, and the formation of literary taste. It also discusses the mediating role of the teacher in the process of literary education, and the school as a space in which this mediation should occur.

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In the context of the studies in the Information Science, the information not just depends on meaning, but the social bows are current of this. The research in development analyse conceptual elements to answer the question about the semiotic foundations of the information mediation processes. This paper aim to know and analyse the semiotic foundations of the information mediation processes in the Information Science context. It presents concepts and reflections regarding the relationship of the information mediation process Charles Peirce's Semiotics, especially, the discussion about the semiotic bases to information mediation process. It discusses the information mediation as a specialization of the communication process, developed, fundamentally, for the human action trying to solve communication and technical problems in sociocultural order.

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Corporate governance can be understood as management mechanisms that through external and internal controls are going to reduce the distance between minority stakeholders and the control power of the company. In that context, the information management, the information mediation and the information dissemination is very necessary, because the establishment of the good communication, quick, clear and voluntary, in order to establish a confidence climate in the relation of the company with the society, creditors, and collaborators especially with investors. In Brazil, the model created by the stock exchange of São Paulo called of new market , brings in his additional conduct rules purpose to them required by the Brazilian legislation and possessed like base the equity in the handling between part, the transparency in the disclosure of information and responsibility in the installment count. This article presents some considerations about the model of information management and accountability based on legal criteria, in additional standards of information disclosure, and the information mediation process relationship the corporate governança in the business environment.

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The way teachers will coordinate the writing appropriation process assumes an especial importance, sharing their knowledge with the deaf student, assigning importance and meaning for what this student was capable to produce, even if his production isn’t resembled to the idealized pattern of an adult writing. This study is proposed to investigate the mediation in rewriting activities, along with deaf students, held by eight trainee students of a Pedagogy course, with ages between 20 and 28 years old. Thereunto, this activities were recorded on video, for later transcription and descriptive analysis, subsided by a new model proposed in the literature. The results indicate: the importance of the rewriting in the understanding of write contents produce by deaf students, the participants’ attitudinal change about their role like coordinator and interlocutor in such activities and the greater teacher’s comprehension about notational and discursive aspects involved in the deaf student write production. These results allowed to conclude the future teachers’ need that will work in inclusive classes or in multifunctional classes, understand and use rewriting activities in their daily pedagogical practice for the appropriation for the promotion of the Portuguese write by the deaf student, user of LIBRAS. It should be noted these teachers’ need to know the LIBRAS’ grammar and have access to linguistic knowledge enabling them to comprehend the nature of the occurrences present in the texts produced by deaf students.

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The information process should be understood as essential to the success of any institution, mainly those that produce knowledge. Information mediation being part of this process must be understood as an action capable of directing the knowledge construction of individuals. The information mediation in universities is a way of mediating the knowledge generated within and outside the university environment, including its specialized audience and to society. Thus the concept of information mediation is discussed in this work and its role within universities and the role of information professionals as information mediators. The social responsibility of universities needs to be reaffirmed into the society and the information is a possible way for the success of this action.