Effects caused by the spinal administration of ketamine S (+) 5% with no preservatives, using a single puncture, and located on the spinal cord and meninges in rabbits

PURPOSE: To evaluate the effect of ketamine S (+) 5% with no preservatives and administered as a subarachnoid single puncture on the spinal cord and meninges of rabbits.METHODS: Twenty young adult female rabbits, each weighing 3500-5000 g and having a spine length between 34 and 38 cm, were divided by lot into two groups (G): 0.9% saline in G1 and ketamine S (+) 5% in G2, by volume of 5 μg per cm column (0.18 mL). After intravenous anaesthesia with ketamine and xylazine, the subarachnoid space was punctured at S1-S2 under ultrasound guidance, and a random solution was injected. The animals remained in captivity for 21 days under medical observation and were sacrificed by decapitation. The lumbosacral spinal cord portion was removed for immunohistochemistry to assess the glial fibrillary acidic protein (GFAP), and histology was assessed using hematoxylin and eosin (HE) stain.RESULTS:No histological lesions were found in the nervous tissue (roots and cord) or meninges in either group.CONCLUSION: The ketamine S (+) 5% unpreserved triggered no neurological or histological lesions in the spinal cord or meninges of rabbits.

Autonomic modulation and its relation with body composition in swimmers

This study compared autonomic modulation in swimmers and non-athletes in relation to body composition. A total of 28 athletes with a mean age of 19.7 +/- 2.9 years were evaluated who had at least 2 years of swimming training, trained approximately 7,000 m per day, with a frequency of 5 days per week, and who competed at national level. The control group was made up of 21 volunteers (23.0 +/- 2.5 years), who did not practice regular physical activity (<2 hours per week). Body composition was estimated using dual-energy x-ray absorptiometry, and autonomic modulation was assessed by heart rate variability (HRV). The results show that there were significant differences in autonomic modulation and body composition between the groups, and that the athletes had a higher overall variability (standard deviation of all normal intervals between consecutive heart beats [SDNN]: 78.1 [72.5-93.5] x 61.1 [56.4-75.7], p = 0.022) and greater autonomic balance (LF/HF: 0.96 [0.88-1.35] x 0.71 [0.56-0.93], p = 0.023), compared with the non-athletes, respectively. In addition, a moderate and positive relation was obtained between fat-free mass and the square root of the squared differences between consecutive heartbeat intervals (RMSSD: r = 0.526, p = 0.004 x r = 0.456, p = 0.038), (SDNN: r = 0.617, p = 0.001 x r = 0.571, p = 0.007) and low frequency (LFms(2): r = 0.517, p = 0.005 3 r = 0.600, p = 0.004) in the athletes and non-athletes, respectively, without a correlation between fat mass (FM). The conclusion is that young highly trained swimmers had lower FM, increased fat-free mass, and better HRV than young adult non-athletes and suggests that a lower quantity of FM and, especially, a greater fat-free mass (FFM) are linked to better autonomic modulation. Thus, this study could contribute to coaches and trainers establishing greater performance by better autonomic modulation and greater quantity of FFM.

A single bout of exercise with a flexible pole induces significant cardiac autonomic responses in healthy men

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Perfil epidemiológico dos pacientes internados na unidade de tratamento de queimaduras do Hospital Estadual de Bauru

Burns are frequent accidents, and they are among the major causes of morbidity and mortality in our society. In Brazil, statistical data on such lesions are relatively scarce, and they are concentrated in a few treatment centers. Data on such accidents allow for specific care to be timely and properly taken in order to provide patients with a better prognosis, in addition to enabling the development of prevention programs as well as fire-prevention safety laws. To characterize the epidemiological profile of users at the Burn Treatment Unit of Bauru State Hospital. Collection of epidemiological data through the e-pront system and from charts of burned inpatients from April 2005 to April 2010. During the studied period, 906 hospitalizations of burned patients occurred, with an annual average of 181.2 individuals. Their mean age was 28.4 years, with a predominance of males. The mean hospitalization period was of 27.6 days, with a median of 16 days and a maximum of 216 days; 14.7% developed to death, with the highest mortality rate in the first two weeks of hospitalization. Second-degree burns were the most frequent; 36.8% of the patients burned less than 10% of their body surface, and there was a gradual frequency reduction when a larger burned surface was taken into account; the greater the affected areas, the higher the number of deaths; 91% resulted from thermal agents, 6% from electric and 2% from chemical agents; scalding was the major cause among all agents, followed by alcohol associated with fire and direct flame. The major area affected areas were the upper limbs. The study shows the need for educational and preventive measures, particularly for the young adult population, by means of educational programs and prevention campaigns

Validação de uma escala colorida de esforço percebido para adultas jovens e idosas em caminhada na esteira

The perceived exertion has been used for the intensity control and exercise prescription. Among the various scales that estimate the perceived exertion, the Borg’s RPE scale is one of the best known. However, for populations with low levels of schooling or with visual difficulties such as the elderly, the application of these scales becomes more difficult. In previous studies, a color scale of perceived exertion was developed to aim for assistance in application of the scale and interpretation of perceived exertion. This scale showed high correlation with the Borg’s scale and proved to be valid to estimate the perceived exertion. Thereby, the aim of this study was to assess the validity of the color scale of perceived exertion to measure the perceived exertion in adult women of different ages. Participated in the study 12 young adult women with age of 21,7 ± 1,5 years old, and 10 elderly women with age of 60,3 ± 3,5 years old. The participants were submitted to an incremental exercise of treadmill walking with stages of 2 minutes duration. The inicial load was 5,5 km/h and inclination of 6% for young women and 2% for elderly women, both with 2% increments at each stage completed, without changing the speed. Heart rate and oxygen comsuption responses were determined at the 30 finals seconds of each stage. At the 60 finals seconds of each stage participants indicated the perceived exertion for the overall body, for the legs and for the chest, primarily in the color scale and following in the tradicional Borg’s scale. The analysis of variance for repeated measures was used to assess the effect of different loads on the perceived exertion and physiological responses. The correlations betwen physiological variables, color scale and Borg’s scale were analyzed in group and individually. In all analysis the significance...(Complete abstract click electronic access below)

O passado no presente: João Gilberto Noll, leitor de Álvares de Azevedo

In the mid-nineteenth century, in his fruitful years of the perhaps best-known shortest literary career, Álvares de Azevedo wrote this verse “As ondas são anjos que dormem no mar” (“The waves are angels who sleep in the sea”). In the presentation of João Gilberto Noll’s young adult novel Anjo das ondas (Angel of the waves) in 2010, Ivan Marques states that the character in the novel, Gustavo, “with his adolescent passion, and torn spirit with overflowing lyrics, could even be compared to our tropical Byron”. João Gilberto Noll establishes a connection between him and Álvares de Azevedo that invites the reader to go beyond a first reading level of his work, seeking evidence of dialogue ratification between two apparently distant writers. The subtle intertextuality exceeds the initial clue and can be detected on Noll’s theme development from the history of Gustavo, a troubled teenager in search of his identity. Noll’s affinity to Álvares de Azevedo can still be captured in his narrative texture, in voices coming from his text; however, they also reveal to be unique and original features of his literary production. An apparent exercise in style shows that each author fulfills his mission by expressing, in his own way, the feeling of his time. In addition, it shows that through aesthetic emotion, literature allows us to transcend time and space.

Efeitos da administração subaracnoidea em punção única, de cetamina S(+) a 5%, sem conservantes, sobre a medula espinal e as meninges de coelhos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Ocorrência de Angiostrongylus cantonensis (Nematoda, Angiostrongylidae) em Achatina fulica (Mollusca, Gastropoda) na Baixada Santista

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Parotidite aguda em adulto jovem sistemicamente saudável: relato de caso clínico

This study reports an unusual case of acute parotitis in a healthy young adult with good oral hygiene. Case Report: The patient sought the Department of Stomatology, at Ponta Grossa State University due to a swollen on the right parotid gland region. The patient underwent clinical and radiological treatments and was prescribed anti-inflammatory drugs and antibiotics. On the fifth day the signs and symptoms had disappeared. Conclusion: The development of acute parotitis in healthy young adults with good oral hygiene is possible, but this makes the diagnosis more difficult. Anti-inflammatory, antibiotic and heat physiotherapy can contribute to the recovery of the signs and symptoms after 5 days of treatment.

Alterações na expressão do Hormônio Concentrador de Melanina (MCH) na área hipotalâmica lateral do rato ao longo do desenvolvimento pós-natal e envelhecimento

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Acoustic radiation force impulse elastography of the spleen in healthy dogs of different ages

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Maxillo-mandibular counter-clockwise rotation and mandibular advancement with TMJ Concepts (R) total joint prostheses Part I - Skeletal and dental stability

The purpose of this study was to evaluate skeletal and dental stability in patients who had temporomandibular joint (TMJ) reconstruction and mandibular counterclockwise advancement using TMJ Concepts total join, prostheses (TMJ Concepts Inc. Ventura, CA) with maxillary osteotomies being performed at the same operation. All patients were operated at Baylor University Medical Center, Dallas TX, USA, by one surgeon (Wolford). Forty-seven females were studied; the average post-surgical follow-up was 40.6 months. Lateral cephalograms were analyzed to estimate surgical and post-surgical changes. During surgery, the occlusal plane angle decreased 14.9 +/- 8.0 degrees. The maxilla moved forward and upward. The posterior nasal spine moved downward and forward. The mandible advanced 7.9 +/- 3.5 mm at the lower incisor tips, 12.4 +/- 5.4 mm at Point B, 17.3 +/- 7.0 mm at menton, 18.4 +/- 8.5 mm at pogonion, and 11.0 +/- 5.3 mm at gonion. Vertically, the lower incisors moved upward -2.9 +/- 4.0 mm. At the longest follow-up post surgery, the maxilla showed minor horizontal changes while all mandibular measurements remained stable. TMJ reconstruction and mandibular advancement with TMJ Concepts total joint prosthesis in conjunction with maxillary osteotomies for counter-clockwise rotation of the rnaxillo-mandibular complex was a stable procedure for these patients at the longest follow-up.

Impact of functional training on cardiac autonomic modulation, cardiopulmonary parameters and quality of life in healthy women

Coordenação de Aperfeiçoamentode Pessoal de Nível Superior (CAPES)

Efeitos da doxicilina na hipertensão arterial induzida pela exposiçao ao chumbo: quantificação de pepídeos vasoativos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise do consumo de extato hidrossolúvel de soja na qualidade do tecido ósseo de ratos jovens adultos

Pós-graduação em Ciência Animal - FMVA