Desenvolvimento de emulsões o/a contendo extrato glicólico de açai e avaliação da atividade fotoprotetora

Sunscreen use is the most common photoprotection alternative used by the population, and so these products should offer improved protection with broad - spectrum, UVA and UVB protection . Vegetal substances have recently been considered as resources for sunscreen formulations due to their UV spectrum absorption and antioxidant properties. The Euterpe oleracea Mart., popularly known as açai, in its che mical composition contain polyphenols compounds, such as anthocyanins and flavonoids , to which antioxidant properties have been attributed . The aim of this work was to develop O/W sunscreens emulsions con taining açai glycolic extract ( AGE) and to evaluate both their physical stability , safety and photoprotective efficacy. The safety of the extract was evaluated by in vitro phototoxicity and cytotoxicity tests. Emulsions containing AGE and sunscreens were formulated using different types and concentrations o f polymeric surfactant (Acrylates/C 10 - 30 Alkyl Acrylate Crosspolymer and Sodium Polyacrylate). The influence of two rheology modifiers (Polyacrylamide (and) C13 - 14/Isoparaffin (and) Laureth - 7 and Carbomer) on the stability was also investigated. Physical stability was evaluated by preliminary and accelerated studies. The macroscopic analyses, pH value and electrical conductivity determinations and rheological behavior were evaluated at different time intervals . The in vivo Sun Protect Factor ( SPF ) was determined according to the International Sun Protection Factor Test Method – 2006 and UVA Protection Factor (FPUVA), wavelength critical and reason SPF/FPUVA were performed according to the method Colipa 2011. The extract did not present cytotoxic ity and phototoxic ity . The stable emulsion containing 5% glycolic extract of açai and 1.0% of sodium poliyacrylate showed pseudoplastic and thixotropic behavior . The sunscreen emulsion containing açai glycolic extract showed a SPF 25.3 and PF - UVA = 14.97. Whe n açai glycolic extract was added in the emulsion sunscreen, no significant increase in the in vivo SPF and FPUVA values were observed. This emulsion showed 1.69 of the SPF/PF - UVA ratio and a critical wavelength value of 378 nm, so may therefore be conside red a sunscreen with UVA and UVB protection.

Programa Nacional de Incentivo à Leitura - PROLER: avaliação da implementação pelo Comitê Potiguar

The National Reading Incentive Program (PROLER) is a national initiative to promote and encourage reading throughout the country, linked to the National Library Foundation (FBN) of the Ministry of Culture (MinC). This research aims to assess the PROLER’s implementation process in the state of Rio Grande do Norte, from the actions of their local committee. The framework is based on contextualize the policies that seek to encourage the book and reading, as well as the processes of implementation and evaluation of public policies. The research is understood as a qualitative descriptive-exploratory study, comprising a single case study. Makes use of semi-structured interview as a tool for data collection, which was attended by 8 members of Potiguar Committee as respondents. The techniques of bibliographical and documentary analysis were used for the analysis and discussion of data obtained from surveys and documents on PROLER; as to the content of the interviews, the technique used was the analysis of conversations. As for the results, the existence of four barriers to program implementation in the state that are worth mentioning is observed: a) the political-administrative discontinuity; b) the limited resources and few partnerships; c) the management of school libraries and absence from the post of librarian in the state and; d) the absence of a process or assessment tool able to evaluate the results or the impacts of actions taken by the Potiguar Committee. It was noticed that these limiting four come PROLER making the implementation of the Rio Grande do Norte a process that, although complying with the national regulations of teacher training and follow school libraries and their needs, not flawed to develop assessments that can measure program impacts, making the feedback process of ineffective policy. Another observation of this study is seen in the fact that the Committee did not get enough to supply their shares resources, as well as not being able to articulate new partnerships, thus contributing negatively to the scope of the program form and, consequently, for the effectiveness of their actions. Has even mentioning the fact that the Committee do nothing regarding the mismanagement of the libraries that are in their care, ie, do not use the power of coercion as guaranteed by the National Policy on Reading and federal laws that treat the school library, and is therefore ineffective in relation to compliance with the program guidelines

Desenvolvimento teórico e experimental de FSS com elementos fractais de Gosper em estruturas de multicamadas

The fractal self-similarity property is studied to develop frequency selective surfaces (FSS) with several rejection bands. Particularly, Gosper fractal curves are used to define the shapes of the FSS elements. Due to the difficulty of making the FSS element details, the analysis is developed for elements with up to three fractal levels. The simulation was carried out using Ansoft Designer software. For results validation, several FSS prototypes with fractal elements were fabricated. In the fabrication process, fractals elements were designed using computer aided design (CAD) tools. The prototypes were measured using a network analyzer (N3250A model, Agilent Technologies). Matlab software was used to generate compare measured and simulated results. The use of fractal elements in the FSS structures showed that the use of high fractal levels can reduce the size of the elements, at the same time as decreases the bandwidth. We also investigated the effect produced by cascading FSS structures. The considered cascaded structures are composed of two FSSs separated by a dielectric layer, which distance is varied to determine the effect produced on the bandwidth of the coupled geometry. Particularly, two FSS structures were coupled through dielectric layers of air and fiberglass. For comparison of results, we designed, fabricated and measured several prototypes of FSS on isolated and coupled structures. Agreement was observed between simulated and measured results. It was also observed that the use of cascaded FSS structures increases the FSSs bandwidths and, in particular cases, the number of resonant frequencies, in the considered frequency range. In future works, we will investigate the effects of using different types of fractal elements, in isolated, multilayer and coupled FSS structures for applications on planar filters, high-gain microstrip antennas and microwave absorbers

Efeitos da sinalização por Sonic Hedgehog sobre a proliferação de células-tronco neurais e gliogênese no córtex cerebral em desenvolvimento

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES

Cloud Stratus: uma plataforma de middleware para desenvolvimento de aplicações em nuvem

Cloud Computing is a paradigm that enables the access, in a simple and pervasive way, through the network, to shared and configurable computing resources. Such resources can be offered on demand to users in a pay-per-use model. With the advance of this paradigm, a single service offered by a cloud platform might not be enough to meet all the requirements of clients. Ergo, it is needed to compose services provided by different cloud platforms. However, current cloud platforms are not implemented using common standards, each one has its own APIs and development tools, which is a barrier for composing different services. In this context, the Cloud Integrator, a service-oriented middleware platform, provides an environment to facilitate the development and execution of multi-cloud applications. The applications are compositions of services, from different cloud platforms and, represented by abstract workflows. However, Cloud Integrator has some limitations, such as: (i) applications are locally executed; (ii) users cannot specify the application in terms of its inputs and outputs, and; (iii) experienced users cannot directly determine the concrete Web services that will perform the workflow. In order to deal with such limitations, this work proposes Cloud Stratus, a middleware platform that extends Cloud Integrator and offers different ways to specify an application: as an abstract workflow or a complete/partial execution flow. The platform enables the application deployment in cloud virtual machines, so that several users can access it through the Internet. It also supports the access and management of virtual machines in different cloud platforms and provides services monitoring mechanisms and assessment of QoS parameters. Cloud Stratus was validated through a case study that consists of an application that uses different services provided by different cloud platforms. Cloud Stratus was also evaluated through computing experiments that analyze the performance of its processes.

Desenvolvimento de estruturas integradas de filtros e antenas para aplicações em sistemas de comunicações sem fio

This paper presents a study of the integration of filters and microstrip antennas, yielding devices named as filtennas for applications in wireless communications systems. The design of these structures is given from the observation of filtennas based integration between horn antennas and frequency selective surfaces (FSS), used in the band X. The choice of microstrip line structures for the development of a new configuration filtennas justifies the wide application of these transmission lines, in recent decades, always resulting in the production of circuit structures with planar light-weight, compact size, low cost, easy to construct and particularly easy to integrate with other microwave circuits. In addition, the antenna structure considered for the composition of filtennas consists of a planar monopole microstrip to microstrip filters integrated in the feed line of the antenna. In particular, are considered elliptical monopole microstrip (operating in UWB UWB) microstrip filters and (in structures with associated sections in series and / or coupled). In addition, the monopole microstrip has a proper bandwidth and omnidirectional radiation pattern, such that its integration with microstrip filters results in decreased bandwidth, but with slight changes in the radiation pattern. The methods used in the analysis of monopoles, and filters were filtennas finite elements and moments by using commercial software Ansoft Designer and HFSS Ansoft, respectively. Specifically, we analyze the main characteristics of filtennas, such as radiation pattern, gain and bandwidth. Were designed, constructed and measures, several structures filtennas, for validation of the simulated results. Were also used computational tools (CAD) in the process of building prototypes of planar monopoles, filters and filtennas. The prototypes were constructed on substrates of glass-fiber (FR4). Measurements were performed at the Laboratory for Telecommunications UFRN. Comparisons were made between simulated and measured, and found good agreement in the cases considered

Análise da dinâmica deposicional das praias de Cacimbinha e do Madeiro, Tibau do Sul-RN, Brasil

The Cacimbinha and Madeiro beaches are located in the eastern coast of Rio Grande do Norte state, in the municipality of Tibau do Sul. Given the indicative of erosion in the coast of this district and the coastal processes acting on the beaches, the global aim of this project is comprehend the evolution of depositional environment on the Cacimbinha beach, moreover, the project seeks to characterize deposits from the Cacimbinha and Madeiro beaches, according to the geomorphologic compartments identified on these beaches; distinguish the coastal features which possibly interact with the Cacimbinha beach; identify the potential relationship between the sediments from the coastal features and the deposits from Cacimbinha beach; understand which depositional processes that prevail at each facies deposited on the beach; and identify the probable sedimentary environments and its energy of deposition through of the materials recorded on the Cacimbinha beach. This study was based on previous bibliographic and field research, both guided by academic works, laws, concepts and theories concerning the physical geography, geomorphology of the quaternary, sedimentary geology and stratigraphy. Thus, the methodology was divided in three steps: Prefield step: office work was performed; Field step: Sampling of facies of sedimentation; PosField step: analysis and integration of data obtained during the research period. Thus, the results showed deposicional facies with distinguished energy in the relief compartments, beach and terrace. After the sedimentary analysis and its interpretation linked to the architecture of the mounted sections based on drilling, it became possible to trace the evolutionary history of this stretch of beach. Therefore, it can be stated that studies performed on coastal areas are of great importance, as long as, around the world, the most part of urban zones are seated on deposits of quaternary age and, then this work improve the knowledge regarding the sedimentary dynamics of this beach, becoming scientific support for management and planning of this area which focus on, mainly, the foreign tourism

Desenvolvimento de novos biolubrificantes hidráulicos derivados dos óleos de maracujá e de moringa in natura e epoxidados

With the increasing environmental awareness, maximizing biodegradability and minimizing ecotoxicity is the main driving force for new technological developments. Thus, can be developed new biodegradable lubricants for use in environmentally sensitive areas. The aim of this study was to obtain new bio-lubricants from passion fruit (Passiflora edulis Sims f. flavicarpa Degener) and moringa (Moringa oleifera Lamarck) epoxidized oils and develop a new additive package using experimental design for their use as a hydraulic fluid. In the first stage of this work was performed the optimization of the epoxidation process of the oils using fractional experimental design 24-1 , varying the temperature, reaction time, ratio of formic acid and hydrogen peroxide. In the second step was investigated the selectivity, thermodynamics and kinetics of the reaction for obtaining the two epoxides at 30, 50 and 70 °C. The result of the experimental design confirmed that the epoxidation of passion fruit oil requires 2 hours of reaction, 50 °C and a ratio H2O2/C=C/HCOOH (1:1:1). For moringa oil were required 2 hours reaction, 50 °C and a ratio of H2O2/C=C/HCOOH (1:1:1.5). The results of the final conversions were equal to 83.09% (± 0.3) for passion fruit oil epoxide and 91.02 (±0,4) for moringa oil epoxide. Following was made the 23 factorial design to evaluate which are the best concentrations of corrosion inhibitor and anti-wear (IC), antioxidant (BHA) and extreme pressure (EP) additives. The bio-lubricants obtained in this step were characterized according to DIN 51524 (Part 2 HLP) and DIN 51517 (Part 3 CLP) standards. The epoxidation process of the oils was able to improve the oxidative stability and reduce the total acid number, when compared to the in natura oils. Moreover, the epoxidized oils best solubilized additives, resulting in increased performance as a lubricant. In terms of physicochemical performance, the best lubricant fluid was the epoxidized moringa oil with additives (EMO-ADI), followed by the epoxidized passion fruit oil with additives (EPF-ADI) and, finally, the passion fruit in natura oil without additives (PFO). Lastly, was made the investigation of the tribological behavior under conditions of boundary lubrication for these lubricants. The tribological performance of the developed lubricants was analyzed on a HFRR equipment (High Frequency Reciprocating Rig) and the coefficient of friction, which occurs during the contact and the formation of the lubricating film, was measured. The wear was evaluated through optical microscopy and scanning electron microscopy (SEM). The results showed that the addition of extreme pressure (EP) and anti-wear and corrosion inhibitor (CI) additives significantly improve the tribological properties of the fluids. In all assays, was formed a lubricating film that is responsible for reducing the coefficient of metal-to-metal wear. It was observed that the addition of EP and IC additives in the in natura vegetable oils of passion fruit and moringa did not favor a significant reduction in wear. The bio-lubricants developed from passion fruit and moringa oils modified via epoxidation presented satisfactory tribological properties and shown to be potential lubricants for replacement of commercial mineral-based fluids.

Caracterização morfológica-sedimentar do vale inciso Apodi-Mossoró e plataforma continental adjacente - Bacia Potiguar Offshore

Systems of incised valleys have been studied in different continental shelves, including the Brazilian continental margin. The interest to characterize this feature is given by the information that it can provide variations on sea level, as well as the ability to host economically significant quantities of hydrocarbons in reservoirs located in deposits filling of the incised valleys. This thesis has the overall objective to characterize the morphology and sedimentary cover of the incised valley Apodi-Mossoró, located in the Northern Continental shelf of Rio Grande do Norte state, adjacent to Areia Branca city. The methodology included the integration of satellite imagery, bathymetric data, sedimentological data, shallow seismic, and the identification of foraminifera. The results indicate that the ApodiMossró incised valley is currently formed by two channels, shallow channel and deep channel, which have distinct morphological and sedimentological characteristics. The deep channel has connection with one of the heads of the Apodi Canyon, located in the slope area. The acquisition, processing and interpretation of shallow seismic data allowed the recognition of the depositional surface, erosional surface, discordance, and sismofaceis. The erosional surface mapped from shallow seismic sections is possibly a indicative of an ancient surface of valley incision, where it would probably be associated with the limit Pleistocene/Holocene. Different sismofaceis were identified and reflect the rise in sea level with standards sometimes agradacional, sometimes progradational. The thickness of sediments on this surface was estimated at a maximum of 22m thick in the central portion of the incised valley. Statistically, there are differences between the adjacent continental shelf and channels, and between these channels, for the content of calcium carbonate, organic matter, sand and mud perceptual, except for the gravel grain size. The analysis of living and dead foraminifera showed the presence of fifty species distributed in regards to morphology, depth and type of sediment. Four type of seismic echocharacteres were identified and mapped, as well as their bedforms, indicating different sedimentary processes along the incised valley. The integration of results suggests an activation of the Apodi-Mossoró incised valley in the Late Pleistocene.

Tendências e projeções da mortalidade pelos cânceres específicos ao gênero no Brasil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES

Desenvolvimento e caracterização de nanoemulsões cosméticas contendo extrato de Opuntia ficus-indica L. Mill e avaliação in vivo da eficácia hidratante

Nanoemulsions are emulsified systems, characterized for reduced droplet size (50- 500nm), which the main characteristic are kinect stability and thermodynamic instability. These are promising systems on cosmetic area due to their droplet size that provide different advantages when compared to conventional systems, among others, larger surface area and better permeability. The Opuntia ficus-indica (L.) Mill is a plant cultivated on Caatinga Brazilian biome, which has great socioeconomic importance to region. This plant shows carbohydrates utilized for cosmetic industry as moisturizing active in their chemical composition. The aim of study was to develop, characterize, evaluate stability and moisturizing efficacy of cosmetic nanoemulsions added to Opuntia ficus-indica (L.) Mill extract. Nanoemulsions preparation was made using a low energy method. Different nanoemulsions were formulated varying the ratio of oil, water and surfactant phases beyond xanthan gum (0.5% e 1%) and Opuntia ficus-indica (L.) Mill hydroglycolic extract addition on 1% and 3%. Obtained nanoemulsions were submitted to preliminary and accelerated stability tests. The evaluated parameters monitored were: macroscopic aspect, pH value, droplet size, zeta potential and polydispersion index, during 60 days on different temperatures. Stable formulations were submitted to moisturizing efficacy assessment by capacitance and transepidermal water loss methodologies during 5 hours. Stable samples were white and showed homogeneous and fluid aspect, pH value was inside ideal range (4,5-6,0) to topical application and droplet size under 200nm characterizing these system as nanoemulsions. Developed nanoemulsions did not decrease transepidermal water loss, however increased the water content on stratum corneum, highlighting the nanoemulsions containing 0.5% of xanthan gum and 1% of hydroglycolic extract. This work presents cosmetic moisturizing nanoemulsions composed to vegetal raw material from Brazilian Caatinga with potential to be used on cosmetic area.

A construção medial no português do Brasil: usos no padrão reclamação digital

This thesis examines the medial construction of the Portuguese of Brazil (PB). It is a construction which describes a causative event in which a non-human subject participant is affected by an action that does not originate from itself. Thus, we are interested in investigating this type of construction, its specific characteristics, motivations and discursive context from its semantic- cognitive and discoursive - pragmatic functions. The research questions are: what is the prototypical structural configuration of the medial construction (MC) in the Portuguese of Brazil? What are its specific discoursive functions? What is the degree of MC transitivity based on the properties proposed by Hopper and Thompson (1980)? We assume that the medial construction has its own structure which particularizes its significant dimension, thus ensuring a certain distance between the one in charge of the event and the affected entity. The theoretical and methodological assumptions is founded on Usage-based Functional Linguistics (FURTADO DA CUNHA; BISPO; SILVA, 2013). It is a research of qualitative- interpretative nature that has prioritized the analysis of occurrences arising from texts produced by users of the Brazilian Portuguese language in effective communicative situation. The database for this study is electronic texts available on the website www.reclameaqui.com.br. The results revealed the existence of different configurations of the medial construction in the Brazilian Portuguese, having as prototypical the one formed by SN + V. From the morphosyntactic and semantic point of view, the construction expresses a subject affected by an action that does not part from itself. As for the pragmatic aspect, the construction expresses an event that seems to have the purpose to emphasize the affected argument and to ignore, intentionally or not, the agent or the causative, since it is irrelevant to the speaker/ listener in the contextual situation.

Morfometria, variação anual no peso e demografia do Tico-tico-rei-cinza (Lanio pileatus: thraupidae) em dois ambientes de caatinga no nordeste do Brasil

The caatinga is considered the only exclusively Brazilian biome, with a total area of 735.000km². It is estimated that about 59% of this area has already been removed and only 2% are protected in conservations units. The region is characteristic by strong seasonality and heterogeneity in their environments. This paper sets generate information on morphological and population patterns Lanio pilatus in two areas of caatinga of Estação Ecológica do Seridó (ESEC – Seridó), Serra Negra do Norte - RN. Data collection was performed in six phases between July 2012 and December 2014, covering the end of the dry and rainy seasons in the region. The captures were performed with nets and individuals captured were marked with metal rings and measured (weight, wing length, tail, tarsus, culmen and tip of the bill to nostril). Through these measures, we observed that only males of open area range in weight during the dry and rainy season, youngs were significantly lower for all parameters measured, and males were larger than females in three characteristics (weight, wing length and tail) in open area and only one (wing length) in the closed area. The population parameters were generated from the mark-capture-recapture technique by program MARK, using the techniques of robust design and CJS. The survival probability of detection and population estimates varied with time. Only individuals of open area fluctuated in their estimates during the study. Overall, the environment was a great mediator of results which increases the need for more studies on the life history of the species in the region.

Desenvolvimento biotecnológico de uma emulsão de uso tópico a base de óleo de rã-touro Rana catesbeiana Shaw

The skin is one of the largest organs of the human body and accounts for about 16% of body weight. The body protection against the external environment microorganisms is one of its most important functions, however is necessary that the skin remain intact for this function be exercised, so that when there is an injury on the skin, the process of restructuring needs to be starts, however this restructuration may also be compromised due to some diseases, justifying even more the need for the development of topical products that promote or accelerate the skin healing. Thus the aim of this study was to extract bullfrog oil and to develop a suitable topical emulsion. Two different oil samples were extracted by hot or organic solvent process. Titration techniques and gas chromatography- mass spectrometry were used to characterize the bullfrog oil. The required hydrophile-lipophile balance (HLBr) of bullfrog oil was determined and a pseudo-ternary phase diagram was constructed. The stability of the topical emulsion was evaluated. Then, cellular viability was determined by MTT assay using normal fibroblasts (3T3) and melanoma (B16F10) cells lines. The hot extraction yield was 60.6%. The major polyunsaturated compounds found were Eicosapentaenoic acid (17.6%) and Arachidonic acid (8.4%). HLBr study demonstrated the presence of stable systems with HLB ranging from 12.1 to 13.5 and the pseudo-ternary phase diagram showed mainly emulsion systems (62%). Topical emulsion showed 390 nm, polydispersity 0.05, zeta potential -25 mV and remained stable for ninety days. The bullfrog oil and topical emulsion did not showed citotoxicity in normal fibroblasts cells. However, these systems showed significantly inhibition of melanoma cells growth. In conclusion, the bullfrog oil presented desirable chemical characteristics required to be used for the development of a pharmaceutical and cosmetic products.

Gato-do-mato-pequeno (Leopardus tigrinus) na Caatinga: ocupação e padrão de atividade de um felídeo ameaçado e pouco conhecido na floresta tropical seca do nordeste do Brasil

While the carnivores are considered regulators and structuring of natural communities are also extremely threatened by human activities. Endangered little-spotted-cat (Leopardus tigrinus) is one of the lesser known species from the Neotropical cats. In this work we investigate the occupancy and the activity pattern of L. tigrinus in Caatinga of Rio Grande do Norte testing: 1) how environmental and anthropogenic factors influence their occupation and 2) how biotic and abiotic factors influence their activity pattern. For this we raised occurrence data of species in 10 priority areas for conservation. We built hierarchical models of occupancy based on maximum likelihood to represent biological hypotheses which were ranked using the Akaike Information Criterion (AIC). According to the results the feline occupancy is more likely away from rural settlements and in areas with a higher proportion of woody vegetation. The opportunistic killing of L. tigrinus and in retaliation for poultry predation close to residential areas can explain this result; as well as more complex vegetation structure can better serve as refuge and ensure more food. Analyzing the records of the species through circular statistics we conclude that the activity pattern is mostly nocturnal, although considerable crepuscular and a small diurnal activity. L. tigrinus activity was directly affected by the availability of small terrestrial mammals, which are essentially nocturnal. In addition, the temperatures recorded in the environment directly and indirectly affect the activity of the little-spotted-cat, as also influence the activity of their potential prey. Generally, the cats were more active when possible prey were active, and this happened at night when lower temperatures are recorded. Moreover, the different lunar phases did not affect the activity pattern. The results improve the understanding of an endangered feline inhabiting the Caatinga biome, and thus can help develop conservation and management strategies, as well as in planning future research in this semi-arid ecosystem.