Parameter sensitivity analysis of surface plasmon resonance biosensor through numerical simulation

Surface based analytical tools have gained more importance for rapid, sensitive and label-free monitoring of molecular recognition events. Surface plasmon resonance (SPR) has played a prominent role in real time monitoring of surface binding events. SPR is increasing its significance especially for the study of ultrathin dielectric layer. This paper investigates the role of thin films of gold, silver and aluminium for protein detection in SPR biosensors. It is shown that the sensitivity, which is indicated by the shift of plasmon dip, is not linearly related to the thickness of protein but quadratic over a specific range. The approach involves a plot of a reflectivity curve as a function of the angle of incidence.

Sensitivity analysis of a sub-wavelength localized surface plasmon resonance graphene biosensor

Localized surface plasmon resonance (LSPR) is a promising detection method for label-free sensing of biomolecules. In this paper, a multilayer design for a LSPR biosensor is presented. In the proposed design, a periodic array of dielectric grating is incorporated on top of a graphene layer in the biosensor. The aim is to improve sensitivity of the LSPR biosensor through monitoring biomolecular interactions of biotin-streptavidin. Sensitivity improvement is obtained for the proposed LSPR biosensor compared with conventional SPR counterparts. In addition, to optimize the design, we have investigated grating geometry including volume factor and grating depth. The outcome of this investigation identifies ideal functioning conditions corresponding to the best design parameters.

A global gap analysis of sea turtle protection coverage

 Although the number and extent of protected areas (PAs) are continuously increasing, their coverage of global biodiversity, as well as criteria and targets that underline their selection, warrants scrutiny. As a case study, we use a global dataset of sea turtle nesting sites (. n=. 2991) to determine the extent to which the existing global PA network encompasses nesting habitats (beaches) that are vital for the persistence of the seven sea turtle species. The majority of nesting sites (87%) are in the tropics, and are mainly hosted by developing countries. Developing countries contain 82% nesting sites, which provide lower protection coverage compared to developed countries. PAs encompass 25% of all nesting sites, of which 78% are in marine PAs. At present, most nesting sites in PAs with IUCN ratification receive high protection. We identified the countries that provide the highest and lowest nesting site protection coverage, and detected gaps in species-level protection effort within countries. No clear trend in protection coverage was found in relation to gross domestic product, the Global Peace Index or sea turtle regional management units; however, countries in crisis (civil unrest, war or natural catastrophes) provided slightly higher protection coverage of all countries. We conclude that global sea turtle resilience against threats spanning temperate to tropical regions require representative PA coverage at the species level within countries. This work is anticipated to function as a first step towards identifying specific countries or regions that should receive higher conservation interest by national and international bodies. © 2014 Elsevier Ltd.

Workspace and sensitivity analysis of a novel nonredundant parallel SCARA robot featuring infinite tool rotation

As demonstrated by the exceptionally successful Delta robot, parallel kinematics Schönflies motion generators (PKSMG) exhibit several advantages over their serial counterparts. Despite its success, the Delta robot suffers from several shortcomings, including a bulky framework and a small workspace-to-footprint ratio. Another drawback is that the kinematic chain generating tool rotation suffers from low torsional stiffness. This letter presents a novel architecture for a nonredundant PKSMG providing infinite tool rotation and an extensive positioning workspace. The workspace and kinematic performance of the proposed architecture are analysed in detail.

Human threats to sandy beaches: a meta-analysis of ghost crabs illustrates global anthropogenic impacts

Beach and coastal dune systems are increasingly subjected to a broad range of anthropogenic pressures that on many shorelines require significant conservation and mitigation interventions. But these interventions require reliable data on the severity and frequency of adverse ecological impacts. Such evidence is often obtained by measuring the response of 'indicator species'.Ghost crabs are the largest invertebrates inhabiting tropical and subtropical sandy shores and are frequently used to assess human impacts on ocean beaches. Here we present the first global meta-analysis of these impacts, and analyse the design properties and metrics of studies using ghost-crabs in their assessment. This was complemented by a gap analysis to identify thematic areas of anthropogenic pressures on sandy beach ecosystems that are under-represented in the published literature.Our meta-analysis demonstrates a broad geographic reach, encompassing studies on shores of the Pacific, Indian, and Atlantic Oceans, as well as the South China Sea. It also reveals what are, arguably, two major limitations: i) the near-universal use of proxies (i.e. burrow counts to estimate abundance) at the cost of directly measuring biological traits and bio-markers in the organism itself; and ii) descriptive or correlative study designs that rarely extend beyond a simple 'compare and contrast approach', and hence fail to identify the mechanistic cause(s) of observed contrasts.Evidence for a historically narrow range of assessed pressures (i.e., chiefly urbanisation, vehicles, beach nourishment, and recreation) is juxtaposed with rich opportunities for the broader integration of ghost crabs as a model taxon in studies of disturbance and impact assessments on ocean beaches. Tangible advances will most likely occur where ghost crabs provide foci for experiments that test specific hypotheses associated with effects of chemical, light and acoustic pollution, as well as the consequences of climate change (e.g. species range shifts).

The three R`s of resilience: redundancy, requisite variety and resources

This paper offers a way of operationalizing resilience according to the sub-systems that comprise a business (technical, social and economic), the kinds of perturbations that might impact a business (local, national and global) and the criteria that determine resilient capacity (redundancy, requisite variety and resources). When a business system has incorporated redundancy, developed requisite variety and adequately monitors its resources, we might then conclude that such a business is a resilient business. The model offered here is theoretical, and is yet to undergo empirical scrutiny. Empirical modeling will enable us to ascertain the strength of a business's internal characteristics against different levels/kinds of external perturbation. Sensitivity analysis of this kind will lead to more in-depth understanding of the dynamics that generate resilient businesses in a complex world.

Cost-effectiveness analysis of a two-stage screening intervention for hepatocellular carcinoma in Taiwan

Background/Purpose

Hepatocellular carcinoma (HCC) has been the leading cause of cancer death in Taiwan since the 1980s. A two-stage screening intervention was introduced in 1996 and has been implemented in a limited number of hospitals. The present study assessed the costs and health outcomes associated with the introduction of screening intervention, from the perspective of the Taiwanese government. The cost-effectiveness analysis aimed to assist informed decision making by the health authority in Taiwan.
Methods

A two-phase economic model, 1-year decision analysis and a 60-year Markov simulation, was developed to conceptualize the screening intervention within current practice, and was compared with opportunistic screening alone. Incremental analyses were conducted to compare the incremental costs and outcomes associated with the introduction of the intervention. Sensitivity analyses were performed to investigate the uncertainties that surrounded the model.
Results

The Markov model simulation demonstrated an incremental cost-effectiveness ratio (ICER) of NT$498,000 (US$15,600) per life-year saved, with a 5% discount rate. An ICER of NT$402,000 (US$12,600) per quality-adjusted life-year was achieved by applying utility weights. Sensitivity analysis showed that excess mortality reduction of HCC by screening and HCC incidence rates were the most influential factors on the ICERs. Scenario analysis also indicated that expansion of the HCC screening intervention by focusing on regular monitoring of the high-risk individuals could achieve a more favorable result.
Conclusion

Screening the population of high-risk individuals for HCC with the two-stage screening intervention in Taiwan is considered potentially cost-effective compared with opportunistic screening in the target population of an HCC endemic area.

A cluster randomized controlled trial of a telephone-based parent intervention to increase preschoolers’ fruit and vegetable consumption

Background: Inadequate fruit and vegetable consumption is associated with increased chronic disease risk and represents a considerable global health burden. Despite evidence that dietary habits track from early childhood, there are few published trials of interventions attempting to increase preschoolers’ fruit and vegetable consumption.

Objective: The Healthy Habits trial aimed to assess the efficacy of a telephone-based intervention for parents to increase the fruit and vegetable consumption in their 3–5-y-old children.

Design: A cluster randomized controlled trial was conducted involving 394 parents of children aged 3–5 y recruited through local preschools. Parents allocated to the intervention received printed resources plus four 30-min telephone calls targeting aspects of the home food environment associated with children's fruit and vegetable consumption. Parents allocated to the control group received generic printed nutrition information. Children's fruit and vegetable consumption was assessed by using the Fruit and Vegetable Subscale of the Children's Dietary Questionnaire, which was administered via telephone interview at baseline and 2 and 6 mo later.

Results: Analysis of all available data showed that children's fruit and vegetable scores were significantly higher in the intervention group than in the control group at 2 mo (P < 0.001) and at 6 mo (P = 0.021). Sensitivity analysis using baseline observation carried forward showed an intervention effect at 2 mo (P = 0.008) but not at 6 mo (P = 0.069).

Conclusions: Telephone-delivered parent interventions may be an effective way of increasing children's fruit and vegetable consumption in the short term. Further investigation to determine whether the intervention effect is maintained in the longer term is recommended.

A multi-objective sensitivity approach to training providers' evaluation and quota allocation planning

The practice of solely relying on the human resources department in the selection process of external training providers has cast doubts and mistrust across other departments as to how trainers are sourced. There are no measurable criteria used by human resource personnel, since most decisions are based on intuitive experience and subjective market knowledge. The present problem focuses on outsourcing of private training programs that are partly government funded, which has been facing accountability challenges. Due to the unavailability of a scientific decision-making approach in this context, a 12-step algorithm is proposed and tested in a Japanese multinational company. The model allows the decision makers to revise their criteria expectations, in turn witnessing the change of the training providers' quota distribution. Finally, this multi-objective sensitivity analysis provides a forward-looking approach to training needs planning and aids decision makers in their sourcing strategy.

Economic evaluation of adult rehabilitation: a systematic review and meta-analysis of randomized controlled trials in a variety of settings

Objectives:
To report if there is a difference in costs from a societal perspective between adults receiving rehabilitation in an inpatient rehabilitation setting versus an alternative setting. If there are cost differences, to report whether opting for the least expensive program setting adversely affects patient outcomes.

Data Sources:
Electronic databases from the earliest possible date until May 2011. All languages were included.

Study Selection
Multiple reviewers identified randomized controlled trials with a full economic evaluation that compared adult inpatient rehabilitation with an alternative. There were 29 included trials with 6746 participants.

Data Extraction
Multiple observers extracted data independently. Trial appraisal included a risk of bias assessment and a checklist to report the strength of the economic evaluation.

Data Synthesis:
Results were synthesized using standardized mean differences (SMDs) and meta-analyses for the primary outcome of cost. The Grading of Recommendations Assessment, Development, and Evaluation was applied to assess for risk of bias across studies for meta-analyses. There was high-quality evidence that cost was significantly reduced for rehabilitation in the home versus inpatient rehabilitation in a meta-analysis of 732 patients poststroke (pooled SMD [δ]=−.28; 95% confidence interval [CI], −.47 to −.09), without compromise to patient outcomes. Results of individual trials in other patient groups (orthopedic, rheumatoid arthritis, and geriatric) receiving rehabilitation in the home or community were generally consistent with the meta-analysis. There was moderate quality evidence that cost was significantly reduced for inpatient rehabilitation (stroke unit) versus general acute care in a meta-analysis of 463 patients poststroke (δ=.31; 95% CI, .15–.48), with improvement to patient outcomes. These results were not replicated in 2 individual trials with a geriatric and a mixed cohort, where costs did not differ between general acute care and inpatient rehabilitation. Three of the 4 individual trials, inclusive of a stroke or orthopedic population, reported less cost for an intensive inpatient rehabilitation program compared with usual inpatient rehabilitation. Sensitivity analysis included a health service perspective and varied inflation rates with no change to the significant findings of the meta-analyses.

Conclusions:
Based on this systematic review and meta-analyses, a single rehabilitation service may not provide health economic benefits for all patient groups and situations. For some patients, inpatient rehabilitation may be the most cost-effective method of providing rehabilitation; yet, for other patients, rehabilitation in the home or community may be the most cost-effective model of care. To achieve cost-effective outcomes, the ideal combination of rehabilitation services and patient inclusion criteria, as well as further data for nonstroke populations, warrants further research.

A systematic review and meta-analysis of diabetes and risk of physical disability and functional impairment - protocol

Background
Diabetes and increased age are known risk factors for physical disability. With the increasing prevalence of diabetes within our aging population, the future burden of disability is expected to increase. To date, there has not been a pooled estimate of the risk for disability associated with diabetes or its precursor states, impaired glucose tolerance and impaired fasting glucose. We aim to conduct a systematic review and meta-analysis of the association between prediabetes and diabetes with disability, and quantify the risk of association.

Methods/design
We will search for relevant studies in Medline via Pubmed, Embase, Cochrane library and Cumulative Index to Nursing and Allied Health Literature (CINAHL), as well as scan reference lists from relevant reviews and publications included in our review. We will review all publications that include studies on human adults (18 years and older) where information is included on diabetes status and at least one measure of disability (Activities of Daily Living (ADL), Instrumental ADL (IADL) or functional/mobility limitation), and where a risk association is available for the relationship between diabetes and/or prediabetes with disability, with reference to those without diabetes.

We will further conduct a meta-analysis to pool estimates of the risk of disability associated with prediabetes and diabetes. Sensitivity analysis will be conducted to assess for publication bias and study quality.Findings from this systematic review and meta-analysis will be widely disseminated through discussions with stake-holders, publication in a peer-reviewed journal and conference presentation.

Potentialities of renewable energy in Victoria, Australia

In utility power system, electricity demand is being covered largely by fossil fueled power generation, which contributes high level of GHG (greenhouse gas) emission and causes global warming worldwide. In order to reduce GHG emission level, most of the countries in the world targeting towards green energy that is power generation from RE (renewable energy) sources. In this paper, it is considered to study prospects of RE sources in particular, solar and wind in Victoria State which are abundant as compared to other sources of renewable. The wind and solar energy feasibility study and sensitivity analysis has been done for Victoria with the aid of HOMER (hybrid optimization model of electric renewable) simulation software. From the study, it has clearly evicted that wind energy combinational HPS (hybrid power system) has more contribution, and high potential than solar PV (photovoltaic) systems for a particular location. This study also investigates the influences of energy storage in the proposed HPS.