Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid

In contrast to the well-characterized effects of specialized proresolving lipid mediators (SPMs) derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), little is known about the metabolic fate of the intermediary long-chain (LC) n-3 polyunsaturated fatty acid (PUFA) docosapentaenoic acid (DPA). In this double blind crossover study, shifts in circulating levels of n-3 and n-6 PUFA-derived bioactive lipid mediators were quantified by an unbiased liquid chromatography-tandem mass spectrometry lipidomic approach. Plasma was obtained from human subjects before and after 7 d of supplementation with pure n-3 DPA, n-3 EPA or placebo (olive oil). DPA supplementation increased the SPM resolvin D5n-3DPA (RvD5n-3DPA) and maresin (MaR)-1, the DHA vicinal diol 19,20-dihydroxy-DPA and n-6 PUFA derived 15-keto-PG E2 (15-keto-PGE2). EPA supplementation had no effect on any plasma DPA or DHA derived mediators, but markedly elevated monohydroxy-eicosapentaenoic acids (HEPEs), including the e-series resolvin (RvE) precursor 18-HEPE; effects not observed with DPA supplementation. These data show that dietary n-3 DPA and EPA have highly divergent effects on human lipid mediator profile, with no overlap in PUFA metabolites formed. The recently uncovered biologic activity of n-3 DPA docosanoids and their marked modulation by dietary DPA intake reveals a unique and specific role of n-3 DPA in human physiology.-Markworth, J. F., Kaur, G., Miller, E. G., Larsen, A. E., Sinclair, A. J., Maddipati, K. R., Cameron-Smith, D. Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid.

Queer penalities: the criminal justice paradigm in lesbian and gay anti-violence politics

Building upon the renewed attention to the ways in which criminology may be ‘queered’ (or not), this article explores how a criminal justice paradigm has influenced lesbian and gay politics through an investigation of anti-homophobic research and lobbying focused on violence and harassment. It asks: What place does criminal justice occupy within sexual politics? Using the Australian state of Victoria as a case study, the article examines how the lesbian and gay anti-violence movement has utilized criminal justice theories, methodologies and approaches to explain and attempt to remedy ‘homophobic hate’. It provides three inter-connected examples of the permeation of criminal justice logics: (1) the victimization survey method, (2) the focus on police reform, and (3) elements of a punitive public discourse surrounding homophobic hate crime. These examples are nevertheless complicated by the persistence of institutionalized violence and state failure to ‘protect’ lesbian, gay, bisexual and transgender (LGBT) lives. These discursive practices contribute to ‘queer penalities’, a term used to describe the ways in which lesbian and gay movements shape and contest the social meaning of terms such as ‘crime’, victimization and punishment.

Hizballah in Syria: the limits of the democracy/moderation paradigm

Hizballah is a popular case study for those seeking to understand democratic transformations in radical groups, although there has never been consensus on whether Hizballah has genuinely transformed. Although Hizballah appeared committed to parliamentary politics between 1992 and 2008, the group’s behaviour in the lead up to the 2008 Doha Agreement and its intervention in Syria in 2013 suggest that democracy has failed to fully ‘tame’ Hizballah. This article applies Schwedler’s model of democratic moderation to Hizballah, showing that there was evidence of a number of limitations in Hizballah’s transition long before 2008.

Mobile health (mHealth) biomedical imaging paradigm

Technology assisted methods for medical diagnosis and biomedical health monitoring are rapidly shifting from classical invasive methods to handheld-based non-invasive approaches. Biomedical imagining is one of the most prominent practices of non-invasive mechanisms in medical applications. This paper considers the medical imaging schemes for Mobile Health (mHealth) applications and studies the feasibility of future mobile systems for accommodating image informatics capabilities.