Vitamin D-fortified milk achieves the targeted serum 25-hydroxyvitamin D concentration without affecting that of parathyroid hormone in New Zealand toddlers

For young children, the level of vitamin D required to ensure that most achieve targeted serum 25-hydroxyvitamin D [25(OH)D] ≥50 nmol/L has not been studied. We aimed to investigate the effect of vitamin D-fortified milk on serum 25(OH)D and parathyroid hormone (PTH) concentrations and to examine the dose–response relationship between vitamin D intake from study milks and serum 25(OH)D concentrations in healthy toddlers aged 12–20 mo living in Dunedin, New Zealand (latitude 46°S). Data from a 20-wk, partially blinded, randomized trial that investigated the effect of providing red meat or fortified toddler milk on the iron, zinc, iodine, and vitamin D status in young New Zealand children (n = 181; mean age 17 mo) were used. Adherence to the intervention was assessed by 7-d weighed diaries at wk 2, 7, 11, 15, and 19. Serum 25(OH)D concentration was measured at baseline and wk 20. Mean vitamin D intake provided by fortified milk was 3.7 μg/d (range, 0–10.4 μg/d). After 20 wk, serum 25(OH)D concentrations but not PTH were significantly different in the milk groups. The prevalence of having a serum 25(OH)D <50 nmol/L remained relatively unchanged at 43% in the meat group, whereas it significantly decreased to between 11 and 15% in those consuming fortified study milk. In New Zealand, vitamin D intake in young children is minimal. Our findings indicate that habitual consumption of vitamin D-fortified milk providing a mean intake of nearly 4 μg/d was effective in achieving adequate year-round serum 25(OH)D for most children.

Orientation relationship, texture and microstructure in electromagnetic processed materials (EPM)

In this work, some of our recent results in microstructure, texture and orientation relationship resulting from the application of an external high magnetic field during diffusional and non-diffusional phase transformation in both steel and functional metallic materials have been summarized. A 12-T magnetic field was applied to the diffusional decomposition of austenite in 0.81C-Fe alloy and martensitic transformation of a Ni-Mn-Ga magnetic shape memory alloy. For the 0.81C-Fe alloy, it was found that the magnetic field induces the formation of proeutectoid ferrite and slightly enhances the <001> fiber component in ferrite in the transverse field direction. The magnetic dipolar interaction between Fe atoms in the transverse field direction accounts for this phenomenon. The magnetic field favors the formation of pearlite with Pitsch-Petch 2 (P-P 2) and Isaichev (IS) orientation relationships (OR) between the lamellar ferrite and cementite. For the Ni-Mn-Ga magnetic shape memory alloy, the magnetic field makes the martensite lamellas to grow in some specific directions with their c-axes [001] orientated to the field direction and transverse field direction.

Functional similarities between pigeon 'milk' and mammalian milk : induction of immune gene expression and modification of the microbiota

Pigeon ‘milk’ and mammalian milk have functional similarities in terms of nutritional benefit and delivery of immunoglobulins to the young. Mammalian milk has been clearly shown to aid in the development of the immune system and microbiota of the young, but similar effects have not yet been attributed to pigeon ‘milk’. Therefore, using a chicken model, we investigated the effect of pigeon ‘milk’ on immune gene expression in the Gut Associated Lymphoid Tissue (GALT) and on the composition of the caecal microbiota. Chickens fed pigeon ‘milk’ had a faster rate of growth and a better feed conversion ratio than control chickens. There was significantly enhanced expression of immune-related gene pathways and interferon-stimulated genes in the GALT of pigeon ‘milk’-fed chickens. These pathways include the innate immune response, regulation of cytokine production and regulation of B cell activation and proliferation. The caecal microbiota of pigeon ‘milk’-fed chickens was significantly more diverse than control chickens, and appears to be affected by prebiotics in pigeon ‘milk’, as well as being directly seeded by bacteria present in pigeon ‘milk’. Our results demonstrate that pigeon ‘milk’ has further modes of action which make it functionally similar to mammalian milk. We hypothesise that pigeon ‘lactation’ and mammalian lactation evolved independently but resulted in similarly functional products.

Targeting viral hepatitis using natural milk protein and traditional medicinal herbs

Hepatitis is a major health related disease spread worldwide with frequent occurrence of epidemics. It is a zoonotic disease which leads to jaundice, anorexia, malaise and death. Although, vaccines have been developed against hepatitis A and hepatitis B, it is a challenge to generate vaccines against other prevalent forms of hepatitis which are equally harmful and spread worldwide. Natural products that are obtained from living organisms and found freely in nature have proven to be effective against several types of hepatitis due to presence of pharmacologically important bioactive compounds. Since they are natural products they do not cause much harm to body and can be easily applied or consumed. Our main focus is on hepatitis E virus (HEV) which is an opportunistic pathogen and leads to acute jaundice. This virus is mainly present in developing countries with poor sanitation facilities and effects individuals having weak immune response, mainly children, old people, organ transplant patients and pregnant women. HEV infection makes the patient more susceptible to infections from other viruses as well as HIV. In this review, we discussed about the natural protein known as lactoferrin which is isolated from milk colostrum and extracts of some medicinal plants that have proven to be effective against various forms of hepatitis. Such form of natural therapies forms the basis of modern medicine and major pharmaceutical discoveries.