Changes in zinc ligation promote remodeling of the active site in the zinc hydrolase superfamily

The zinc hydrolase superfamily is a group of divergently related proteins that are predominantly enzymes with a zinc-based catalytic mechanism. The common structural scaffold of the superfamily consists of an eight-stranded β-sheet flanked by six α-helices. Previous analyses, while acknowledging the likely divergent origins of leucine aminopeptidase, carboxypeptidase A and the co-catalytic enzymes of the metallopeptidase H clan based on their structural scaffolds, have failed to find any homology between the active sites in leucine aminopeptidase and the metallopeptidase H clan enzymes. Here we show that these two groups of co-catalytic enzymes have overlapping dizinc centers where one of the two zinc atoms is conserved in each group. Carboxypeptidase A and leucine aminopeptidase, on the other hand, no longer share any homologous zinc-binding sites. At least three catalytic zinc-binding sites have existed in the structural scaffold over the period of history defined by available structures. Comparison of enzyme-inhibitor complexes show that major remodeling of the substrate-binding site has occurred in association with each change in zinc ligation in the binding site. These changes involve re-registration and re-orientation of the substrate. Some residues important to the catalytic mechanism are not conserved amongst members. We discuss how molecules acting in trans may have facilitated the mutation of catalytically important residues in the active site in this group.

Metaphors, stigma and the ‘Alzheimerization’ of the euthanasia debate

This paper reports the findings of an unobtrusive research inquiry investigating the possible use and misuse of Alzheimer’s disease in public policy debate on the legalization of euthanasia. The component of the study being reported identified the problematic use of five key metaphors: the Alzheimer metaphor, which in turn was reinforced by three additional metaphors – the epidemic metaphor, the military metaphor, and the predatory thief metaphor; and the euthanasia metaphor. All metaphors were found to be morally loaded and used influentially to stigmatize Alzheimer’s disease and mediate public opinion supporting the legalization of euthanasia as an end-of-life ‘solution’ for people with the disease. It is contended that, in the interests of promoting intellectual honesty and giving proper recognition to the extraordinary complexity of the issue, the problematic use and influence of metaphoric thinking in the public debate about Alzheimer’s disease and euthanasia needs to be made transparent, questioned and challenged.

History researcher development and research capacity in Australia and New Zealand

 This article presents data and discussion on history researcher development and research capacities in Australia and New Zealand, as evidenced in analysis of history PhD theses’ topics. The article is based on two independent studies of history PhD thesis topics, using a standard discipline coding system. It shows some marked differences in the Australian and New Zealand volumes and distributions of history PhDs, especially for PhDs conducted on non-local/national topics. These differences reflect national researcher development, research capacities and interests, in particular local, national and international histories, and have implications for the globalisation of scholarship. Thesis topics are used as a proxy for the graduate’s research capacity within that topic. However, as PhD examiners have attested to the significance and originality of the thesis, this is taken as robust. The longitudinal nature of the research suggests that subsequent years’ data and analysis would provide rich information on changes to history research capacity. Other comparative (i.e. international) studies would provide interesting analyses of history research capacity. There are practical implications for history departments in universities, history associations, and government (PhD policy, and history researcher development and research capacity in areas such as foreign affairs). There are social implications for local and community history in the knowledge produced in the theses, and in the development of local research capacity. The work in this article is the first to collate and analyse such thesis data either in Australia or New Zealand. The comparative analyses of the two datasets are also original.

Magical realism and experiences of extremity

Examining magical realist texts including Tim O’Brien’s Going After Cacciato (1991), and Jonathan Safran Foer’s Everything is Illuminated (2002) and Extremely Loud and Incredibly Close (2006), this paper discusses how magical realism examines the extremities of trauma and fear, proposing that magical realist narratives afford a unique ability to represent trauma in a way that is not open to the stylistics of literary realism. Blending the real or believable with the fantastically outrageous, magical realist narratives typically destabilise and disorder privileged centres of ‘truth’ and ‘reality’, demonstrating the constructedness of knowledge and history. Accordingly, magical realist strategies are frequently used in interventionist or counter narratives that refuse to adhere to privileged versions of truth or history and insist upon a multiplicity of experience. The majority of magical realist scholarship explores how the genre undermines hegemonic perspectives of history to clear a space for marginal representations of the past. However, as this paper argues, magical realist narratives also provide a unique space for writing about experiences of extremity. Examining the role of fantasy in representations of violence and trauma, this paper proposes that rupturing a realist narrative with the magical or un-real accommodates representations of extremity by conveying the ‘felt’ experience of trauma.

Barry Hindess and the critique of democracy

In the wake of the collapse of the Communist regime in the Soviet Union, liberal democracy was triumphantly celebrated as the ‘‘end of history.’’ Against this backdrop, Hindess wrote a number of critical essays launching his intellectual critique of liberal democracy. His approach was primarily conceptual, highlighting the problems and weaknesses of the conceptualization of democracy and democratization. This article reviews and offers a brief assessment of the key arguments made in Hindess’ writings on democracy and democratization. In particular, it attempts to summarize the methodological steps through which Hindess engages conceptual critique. While offering an appreciation of Hindess’analysis, insight, and intellectual integrity, it also addresses some difficulties in his arguments.

Teaching and learning history in primary schools : pedagogical shifts, complexities and opportunities

From 2011 the teaching and learning of History will be expanded into all primary schools (Kindergarten – Year 6) throughout Australia under a National Curriculum, including the formal preschool/kindergarten year. History as one of four core subjects will replace current studies of society and environment curriculum taught in primary schools across. The curriculum implementation process will involve a cultural and pedagogical shift as primary teachers make adjustments to the discipline of History. This article begins with an outline of the current curriculum context. An analysis of the New South Wales Human Society and Its Environment and the Australian Curriculum: History Draft Consultation documents follows. The findings indicate that the History Draft Consultation lacks clear guidance for teachers and has a number of shortcomings compared to the NSW HSIE syllabus. There are opportunities, however, for primary teachers because of the broad similarities of content knowledge in both documents and the embedded historical concepts in the NSW syllabus document.

Australia, Papua New Guinea, and a communal blindness in our history education

The teaching of history to Australians has been under the spotlight in recent years as experts, commentators, and politicians vie for command of the uses to be made of the past. This was very evident in the — one hopes — now concluded ‘history wars’ of the last decade or so. But the old warriors are oiling their rusty swords in preparation for what may be yet another battle, perhaps one that will be particularly bloody in this election year. The field for this battle will be broadly centred on the new national history curriculum, being developed by the Australian Curriculum, Assessment, and Reporting Agency (ACARA).

Exhibit review : Focus on strangers: photo albums of World War II, Stadtmuseum, Jena, Germany, 2011

Focus on Strangers: Photo Albums of World War II is based on a collaborative research project conducted by two German universities (Carl von Ossietzky Universität Oldenburg and Friedrich Schiller Universität Jena) and was conceptualized in cooperation with four German city museums in Oldenburg, Munich, Frankfurt, and Jena. While the exhibition continues a tradition of museological projects examining Germany’s war history, such as the Wehrmachtsaustellung, which provoked fi erce public debate, Focus on Strangers moves beyond most conventional approaches in a signifi cant way. Th e exhibition pays tribute to the recent development in which private traces of memory have become part of the public perception of history, in this case the history of World War II.

Teaching history in Australian museums: pedagogy and praxis

This research examines the work of museum educators who teach history to secondary students in ‘formal’ education programs in Australian museums. It challenges the dominant constructivist paradigm and proposes that educators use a history pedagogy model to actively engage students in the dynamic process of learning history in museums.

Stylised configurations of trauma: faking identity in Holocaust memoirs

Exploring a series of fraudulent Holocaust memoirs-Herman Rosenblat's Angel at the Fence, Misha Defonseca's Misha: A Mémoire of the Holocaust, Binjamin Wilkomirski's Fragments and Helen Demidenko's The Hand That Signed the Paper-, this paper argues that fakes are not some 'bogus Other' (Ruthven 3) of 'genuine' literature but in fact parodic works that reflect on the tenuous nature of both the past and the notion of self. Indeed, the revelation of a fraudulent memoir exposes the investments of a public culture in notions of the real-firstly, in terms of an authentic identity and secondly, in relation to a genuine literary experience. The Holocaust frauds perpetuated by Rosenblat, Defonseca, Demidenko and Wilkomirski, in exploiting an historical phenomena regarded as sacrosanct, highlight and utilise the commodification of trauma in both public and literary arenas, manipulating discourses of victimhood and authenticity in order to interrogate the boundaries of the real and the unreal and, indeed, to reveal the faultlines in literary culture per se. Less interested in literary classifications, however, than in notions of history and identity, this paper contends that the scandals surrounding fakes are fundamental to understanding anxieties about the connection between word and world, and the strange expectation that literature is able to provide access to something 'true'.

Segregation-of-duties conflicts in the insider threat landscape: an overview and case study

Many insider attacks originate from misuse of privileges granted by organizations to their internal employees, contractors or third-party service providers. A fundamental means of ensuring that conflicts of privilege cannot occur is to segregate role allocations in order to ensure that no individual can perform a task from beginning to end. In this paper, we provide background on insider attacks in connection with conflicts in Segregation of Duties, and present the current strategies for preventing and detecting such conflicts. To illustrate how a conflict can occur and what can result, we present an in-depth case study demonstrating a conflict in Segregation of Dutiesin an organization, along with the consequent fraud, and we discuss how it might have been prevented.

Contextualizing palimpsest of collective memory in an urban hertigae site : case Study of Chahar Bagh, Shiraz - Iran

A landscape or site, which has been inhabited for long, consists of layers of history. This history is sometimes reserved in forms of small physical remnants, monuments, memorials, names or collective memories of destruction and reconstruction. In this sense, a site/landscape can be presumed as what Derrida refers to as a ‘palimpsest’. A palimpsest whose character is identified in a duality between the existing layers of meaning accumulated through time, and the act of erasing them to make room for the new to appear. In this study, the spatial collective memory of the Chahar Bagh site which is located in the historical centre of Shiraz will be investigated as a contextualized palimpsest, with various projects adjacent one another; each conceptualized and constructed within various historical settings; while the site as a heritage is still an active part of the city’s cultural life. Through analysing the different layers of meaning corresponding to these adjacent projects, a number of principals for reading the complexities of similar historical sites can be driven.

The genealogy of celebrity

Understanding the complexity with which celebrity has been imbricated in cultures over time requires observing it as an elaborate discourse that shapes knowledge and power. This essay situates this section of the book in terms of the themes of history and significance of celebrity.

Book review : 1835 : the founding of Melbourne and the conquest of Australia

Book review of 1835: the Founding of Melbourne and the Conquest of Australia. By James Boyce (Melbourne: Black Inc, 2011), ISBN 978-1-86395-475-4