Genome - wide association study identifies novel breast cancer susceptibility loci

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r² > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10^-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.

Towards a cyberspatial pedagogy : exploring synchronous online learning potentials

It has been a quarter of a century since William Gibson (1984) coined the term cyberspace in his seminal science fiction novel Neuromancer. Subsequently, a proliferation of online teaching technologies have emerged supporting Virilio’s (1991) contention that, “time and space have ceased to function as meaningful dimensions to human thought and action.” The aim of this presentation is to discuss and demonstrate the innovative modification of an online, synchronous learning environment, Elluminate Live! (eLive), which allows participants to transcend the spatial dimension. Specifically, we present an example of good practice which aimed to enhance student engagement by implementing a structured online tutorial series which replicated the entire first year psychology on-campus tutorial series in the eLive environment. We discuss Student Evaluation of Teaching and Units (SETU) results which support the utility of this pedagogic strategy. Finally, we outline various challenges for the virtual teacher who wishes to implement a structured learning program in the eLive environment.
Gibson, W 1984, Neuromancer, Ace Books, New York, USA.
Virilio, P 1991, The aesthetics of disappearance, Semiotext(e), New York, USA.

Paths to Buddhahood : the "sudden" and "gradual" awakening models in Mah ̄y n̄a and Vajray n̄a Buddhism

Examines the graduated paths of Mah ȳn̄a and Vajrayn̄a Buddhism and the instantaneous paths of Ch'an/Zen, rDzogs chen and Mahm̄udr.̄ The main contention between these approaches relates to how the mental defilements are to be purified and how the positive qualities of Buddhahood are to be realised. After comparing and examining the paths it is argued that the polarisation of the "sudden" and "gradual" approaches is the result of the critical philosophies of late Indian and Tibetan Buddhism, rather than a real spiritual dilemma for adherents of either path.

Western propaganda models reconsidered : the "Catherine Whell" of censorship circumvention in developing world internal conflicts

This study is a deep-text analysis of military censorship applied to the national press in the Sri Lankan conflict. We examine press coverage of two Sri Lankan military operations, namely Operation Jayasikurui (1997) and the Capture of Elephant Pass (2000), to identify patterns of signification that help us construct a novel theory of conflict reporting under censorship within the context of ethnic, intrastate conflict. Our study shows that Sri Lankan newspapers, while abiding by censorship regulations, contradictorily also manoeuvred around these regulations as if censorship did not exist. Noteworthy were the censorship circumvention techniques that were used. For example, journalists taught readers how to ‘read’ blank space. They used commentary to educate readers how to read the straight news. They used conflict frames to overcome bias towards official viewpoints. They used multi-source confirmation to avoid pre-dominance of official views. They used respectful words rather than demonised opponents. Great attention
was paid to victims of the conflict, destruction of life and property, and civil society. Our findings do not accord well with previous theoretical models of the media role in society and of press censorship under conflict. The Sri Lankan press is highly intertwined within its cultural context and follows its own value system. We propose the ‘Catherine Wheel Model of Censorship Circumvention’ about press behaviour in times of internal conflict. Our model attempts to explain internal conflict within the developing world context in which the press system is based deeply in culture and is more accustomed to circumventing censorship than obeying it.

The short-term responses of small mammals to wildfire in semiarid mallee shrubland, Australia

Context. Wildfire is a major driver of the structure and function of mallee eucalypt- and spinifex-dominated landscapes. Understanding how fire influences the distribution of biota in these fire-prone environments is essential for effective ecological and conservation-based management.

Aims. We aimed to (1) determine the effects of an extensive wildfire (118 000 ha) on a small mammal community in the mallee shrublands of semiarid Australia and (2) assess the hypothesis that the fire-response patterns of small mammals can be predicted by their life-history characteristics.

Methods. Small-mammal surveys were undertaken concurrently at 26 sites: once before the fire and on four occasions following the fire (including 14 sites that remained unburnt). We documented changes in small-mammal occurrence before and after the fire, and compared burnt and unburnt sites. In addition, key components of vegetation structure were assessed at each site.

Key results. Wildfire had a strong influence on vegetation structure and on the occurrence of small mammals. The mallee ningaui, Ningaui yvonneae, a dasyurid marsupial, showed a marked decline in the immediate post-fire environment, corresponding with a reduction in hummock-grass cover in recently burnt vegetation. Species richness of native small mammals was positively associated with unburnt vegetation, although some species showed no clear response to wildfire.

Conclusions. Our results are consistent with the contention that mammal responses to fire are associated with their known life-history traits. The species most strongly affected by wildfire, N. yvonneae, has the most specific habitat requirements and restricted life history of the small mammals in the study area. The only species positively associated with recently burnt vegetation, the introduced house mouse, Mus domesticus, has a flexible life history and non-specialised resource requirements.

Implications. Maintaining sources for recolonisation after large-scale wildfires will be vital to the conservation of native small mammals in mallee ecosystems.

When planes fall out of the sky : the war body on screen

I can’t keep my eyes off the war body, even though in the repeated seeing of it I feel nauseous: implicated in, and affected by, its painful coming into being. In this age of the War on Terror, wherever I look, wherever I am directed to look by the all-seeing “vision machines” that “illuminate” our identities (Virilio 1994, 70), the body of the soldier, terrorist, hostage, and victim come into troubling view. These war bodies are real in the ontological and phenomenological sense; they are also metaphoric, simulated, and discursive. In this chapter I will define and explore the complex ways in which these three articulating axis—war, in its militaristic and ideological sense; the screen, in all its multifaceted forms and contexts; and the body, individual and social—conjoin and synthesize, disintegrate and dislocate, in a phantasmagoric but simultaneously desperately real collision of power, desire, and control. My main contention will be that the war body on screen is a “sickening” creation that we have desired into being, so that we may feel, better understand, and be taken over by its terror. This terror of living ultimately helps ensure our docility, a docility required by the late capitalist nation-state; it also reconnect us to our bodies in profoundly moving and potentially challenging ways.

Are the Fama–French factors proxying news related to GDP growth? The Australian evidence.

Inspired by Vassalou (J Financ Econ 68:47–73, 2003), we investigate the contention that the Fama and French (J Financ Econ 33:3–56, 1993) model’s ability to explain the cross sectional variation in equity returns is because the Fama–French factors are proxying for risk associated with future GDP growth in the Australian equities market. To assess the validity of Vassalou’s findings, we augment the CAPM and the Fama–French model with a GDP growth factor and run system regressions of the GDP-enhanced models using the GMM approach. Our results suggest that news about future GDP growth is not priced in equity returns and that any ability that SMB and HML exhibit in explaining equity returns is not because they contain information about future GDP growth.

Identification of a by-product of nitric oxide synthase activity in human acute brain injury with in vivo proton magnetic resonance spectroscopy

BACKGROUND AND PURPOSE: Laboratory studies have been used to identify nitric oxide as a notable mediator in neuronal death after acute brain injury. To our knowledge, this has not previously been confirmed with in vivo study in humans. Our purpose was to seek in vivo evidence for the induction of nitric oxide synthase (NOS) in human acute brain injury by using proton MR spectroscopy.

METHODS: In vitro proton MR spectra were obtained in neural extracts from 30 human cadavers, and in vivo spectra were obtained in 20 patients with acute brain injury and in a similar number of control subjects.

RESULTS: We identified a unique peak at 3.15 ppm by using in vivo proton MR spectroscopy in eight of 20 patients with acute brain injury but not in 20 healthy volunteers (P < .002). On the basis of in vitro data, we have tentatively assigned this peak to citrulline, a NOS by-product.

CONCLUSION: To our knowledge, our findings suggest, for the first time, that excitotoxicity may occur in human acute brain injury. Confirmation with the acquisition of spectra in very early acute cerebral injury would provide a rationale for the use of neuroprotective agents in these conditions, as well as a new noninvasive method for quantification.

Making difference SUPER : a critical approach to the politics of celebrity-authored children's books

Recent years have seen a flood of celebrity-authored children’s books enter the children’s literature marketplace. This paper tracks the evolution of this phenomenon as it pertains to contemporary celebrity culture, and responds to the question: what are the embedded messages about identity at play in such texts? The key contention here is that these works endorse celebrity as the most desirable identity category for the children of the new millennium, going so far as to position difference as a commodity to be traded in the quest for fame. Using critical theory around celebrity culture, and through a close reading of a short celebrity-authored picture book, this paper demonstrates that far from being innocuous pieces of popular culture, such books beckon children into a world that increasingly values visibility and stardom above all else.

Species richness and evenness in Australian birds

Species richness and evenness are the two major components of biodiversity, but the way in which they are interrelated is a subject of contention. We found a negative relationship between the two variables for bird communities at 92 woodland sites across Australia and sought an explanation. Actual evapotranspiration (AET) was by far the best predictor of species richness. When AET was controlled for, the relationship between richness and evenness became nonsignificant. Richness is greater at sites with higher AET because such sites support a greater number of individuals. However, such sites have a greater number of rare species, resulting in lower evenness. A complicating factor is that evenness is best predicted by degree of vegetation cover, with sparsely vegetated sites having significantly lower evenness. We conclude that there are two competing ecological processes, related to energy and water availability, that determine richness and evenness. The first drives total abundance (leading to high richness, low evenness), while the second drives productivity and niche availability (leading to high richness, high evenness). The relative strength of these two processes and the observed relationship between richness and evenness are likely to depend on the scale of the analysis and the species and range of habitats studied.

Researching Moslem-Christian marriages : extrapolating from mixed-faith couples towards the practices of Convivencia

Moslem–Christian marriage can be seen as a kind of ‘testing place’ for examining and appreciating the practices of difference. This article offers a summary from a recent local research project which investigated these relationships (Ata, 2003). The empirical data from the study was ‘milled’ for its potential to inform practice, a process that generated four themes that practitioners may find useful in their attempts to design practice approaches that are sensitive to alternative anthropologies. Beginning from the contention that the otherness of those for whom we work can be a mirror for our own cultural and practice assumptions, we extrapolate from these themes to practise with other examples of diversity. It is argued that our efforts to practise with diverse populations will be unengaging, even colonising, unless we are able to denaturalise our own positions.

Multifactorial influences on and deviations from medication administration safety and quality in the acute medical/surgical context

Background and Aims: Although numerous factors influence medication administration, our understanding of the interplay of these factors on medication quality and safety is limited. The aim of this study was to explore the multifactorial influences on medication quality and safety in the context of a single checking policy for medication administration in acute care.

Approach: An exploratory/descriptive study using non-participant observation and follow-up interview was used to identify factors influencing medication quality and safety in medication administration episodes (n = 30). Observations focused on nurses’ interactions with patients during medication administration, and the characteristics of the environment in which these took place. Confirmation of observed data occurred on completion of the observation period during short semi-structured interviews with participant nurses.

Findings: Findings showed nurses developed therapeutic relationships with patients in terms of assessing patients before administering medications and educating patients about drugs during medication administration. Nurses experienced more frequent distractions when medications were stored and prepared in a communal drug room according to ward design. Nurses deviated from best-practice guidelines during medication administration.

Implications: Nurses’ abilities and readiness to develop therapeutic relationships with patients increased medication quality and safety, thereby protecting patients from potential adverse events. Deviations from best-practice medication administration had the potential to decrease medication safety. System factors such as ward design determining medication storage areas can be readily addressed to minimise potential error.

Conclusions: Nurses displayed behaviours that increased medication administration quality and safety; however, violations of practice standards were observed. These findings will inform future intervention studies to improve medication quality and safety.

Australia's defence policy : a market-state approach?

In 2002, Professor Philip Bobbitt published 'The Shield of Achilles', in which he postulates that the nation-state is evolving into a fundamentally new form - the market state. It is my contention that Australia is evolving into something approximating Bobbitt's market-state and therefore its defence policy shuld be informed by market-state strategy.

Relationships, the role of individuals and knowledge flows in the internationalization of service firms

This article develops a new conceptual model of knowledge flows within international service firms. Our model takes explicit account of the critical role of relationships and the individual as being central to the process of knowledge transfer for service firms. The model is then validated with data collected from five international service firms using critical event analysis techniques. The findings reinforce our contention that the individual plays a critical role in the process of knowledge transfer and that relationships form an integral part of this process. The implications of this finding are also discussed.

Enabling organizational cultural change using systemic strategic human resource management – a longitudinal case study

Researchers report that successful cultural change in an organization is difficult to achieve. This research contends that it is more likely to be successful when a systemic approach to strategic human resource management (SHRM) is used to facilitate the change. The contention was tested in an action research case study and longitudinal assessment of change in a large Australian public sector agency. A clear finding from this research is that the cultural change had been sustained through the systemic application of SHRM.