Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 1 historical and established therapies

Multiple sclerosis (MS) is a potentially life-changing immune mediated disease of the central nervous system. Until recently, treatment has been largely confined to acute treatment of relapses, symptomatic therapies and rehabilitation. Through persistent efforts of dedicated physicians and scientists around the globe for 160 years, a number of therapies that have an impact on the long term outcome of the disease have emerged over the past 20 years. In this three part series we review the practicalities, benefits and potential hazards of each of the currently available and emerging treatment options for MS. We pay particular attention to ways of abrogating the risks of these therapies and provide advice on the most appropriate indications for using individual therapies. In Part 1 we review the history of the development of MS therapies and its connection with the underlying immunobiology of the disease. The established therapies for MS are reviewed in detail and their current availability and indications in Australia and New Zealand are summarised. We examine the evidence to support their use in the treatment of MS.

Australia’s Colombo plans, old and new: international students as foreign relations

This article draws on recent research and policy developments to make a case for considering international students as an important component of Australian foreign relations. It links historical and contemporary Australian experiences of international students, especially in the Colombo Plan and New Colombo Plan, to the field of public diplomacy, and sets an agenda for further research in this direction. It highlights the need to recover student voices and to be sensitive to the emergence of everyday or ‘vernacular’ internationalism, as a phenomenon of international students visiting, traveling and otherwise encountering different groups of Australians. It suggests a need to take up anew this form of inquiry for both earlier postwar student experiences and the post-1980s period, in which international students’ voices are frequently silenced by debates over commodification, funding needs, and neo-liberal economics.

Ships, planes and automobiles – the perils and pluses of place - making in an outer Melbourne suburb

Building a new suburb is increasingly seen as creating a “place” as well as a set of houses and neighbourhoods. Developers view “place-making” as a way to differentiate one estate from another and to capture a market segment; planners see the practice as the basis of good master planning. Local governments too support the concept to give residents a sense of pride and identity. While usually seen as a contemporary exercise, imprinted on the blank slate of greenfield sites, the experience of at least one outer suburb suggests that place-making is as much historical as contemporary and may be both a welcome element of a community and a focus of disaffection. The example of Point Cook in Melbourne’s west offers a range of iconic “places” – historical and contemporary markers of identity and difference – which have formed both the basis of local pride but also tension. Thus the RAAF base, Point Cook Homestead and Werribee Mansion long pre-dated the expansion of the city but they have been embraced as centres of pride, historical achievement and as tourist attractions. In contrast, a massive pirate-ship playground built in the centre of a park by a developer as a marker of difference and centre of community attraction was widely appreciated before being burned to the ground! This paper will report on a sample of resident experiences of place-making in outer suburban Melbourne which highlights some of the local complexities of place-making.

"The whole reflected world shuddering": active aesthetics and contemporary Australian poetry

This article maps the landscape of contemporary Australian poetry, arguing that that we are witnessing a paradigmatic shift that now accommodates ancient storytelling and cultures alongside emergent poetic forms and communities. It considers how contemporary poems reflect key cultural movements while themselves enacting a movement towards new forms of knowing.

Religion and contemporary society

What is religion and what is spirituality? Can you be religious and spiritual at the same time? Is religion's influence on society declining? What role does religion play in social change? Do religions foster cultures of violence or social harmony?Sociologists of religion have long grappled with these questions. While there is no agreed definition of either religion or spirituality, scholars have provided useful explanations to help us understand these terms and the changing place of religion in contemporary societies. We will examine some of these questions and frameworks in this chapter. We will also investigate how religions can contribute towards or undermine the creation of peaceful societies. These aspects of religion are of most interest to governments, non-governmental organisations and the media, particularly after the tragic events of 11 September 2001. More recently, religions have become the subject of significant public scrutiny and debate: This has occurred in parallel with a dramatic growth in the number of people declaring themselves as having 'no religion' in Western societies.

Christianity and the shaping of Vanuatu’s social and political development

The Pacific island state of Vanuatu has been considerably shaped by its Christian heritage. Indeed, the role of the various Christian Churches has been pivotal in the development and sustenance of Vanuatu prior to and since its Independence. These Churches include Anglican, Catholic, Pentecostal and evangelical denominations. Missionaries and later local Church leaders were involved directly in Independence movements and shaped the legal and social infrastructure of this nation. This involvement and influence has continued to the present. This article will consider the role the Church has played in the development of Vanuatu. First, a case study analysis of both the historical and contemporary role the Church has played in the development of Vanuatu will be presented. This review will consider the impact of both key individual Church leaders who played central roles in Vanuatu’s Independence. Secondly, the paper will consider the contemporary role Christian Churches play in the provision of social service- including education and health-across Vanuatu. It will conclude that Christianity has therefore played and continues to play a central role in the political and social development of Vanuatu.

Theorising men's violence towards women in refugee families : towards in intersectional feminist framework

Violence against women perpetrated by male partners, or ex-partners. is one of the most concerning and prevalent public health issues in the world today and is a major cause of injury and mental illness among women and children. Violence against women occurs in most societies irrespective of culture, socio-economic status or religion. Nevertheless, it has been identified that immigrant and refugee women are particularly at risk in cases of domestic violence (Easteal 1996: Narayan 1997; Human Rights Watch 2000; Walter 2001: Perilla 2003: Kang Kahler & Tesar 2003:). To make sense of this issue. we articulate an intersectional feminist framework that we used to analyse the results of an empirical investigation of men's violence against women in refugee families in Melbourne. II)

Although this research has investigated the complex field of domestic violence, culture. trauma and historical and contemporary disadvantage, it has a fundamental prerequisite standing that regardless of past and current experiences; men must take responsibility for their violence against women. Our concern is to understand how male domination manifests itself within each culture and emerging, changing cultures in the diaspora, to explore the connections with men's violence against women within the unique domain of the refugee experience.

Playing at bullying : the postmodern ethic of Bully (Canis Canem edit)

This essay discusses Bully (Canis Canem Edit), considering the game's antecedents (narratives involving young people in school settings) and the features which set it apart from other teen texts. It discusses the controversy surrounding the game and comes to the conclusion that the principal reason
for unease on the part of parents and educational authorities is that Bully's postmodernist ethic evades the binaries of liberal humanism and calls into question the foundations on which conventional ethical systems are based. Tbe paper considers several episodes from the game to flesh out its arguments about how the game manifests features of postmodernist textuality in its propensity for simultaneously deploying and interrogating references to historical and contemporary cultural practices.

Picturing Currere towards c u r a : rhizo-imaginary for curriculum

This critical inquiry in curriculum studies uses poststructuralist and Deleuzian rhizomatic approaches alongside an original 'picturing' methodology. The author genealogically maps historical and contemporary curriculum theorising to deconstruct curriculum 'development' and foreground currere (curriculum reconceptualising). In performing Deleuzian philosophy, his proposed c u r a reimagines curriculum via currere to envision generatively living-learning

From hysteria to transgenderism

This thesis covers historical, theoretical, and clinical grounds to re-examine historical and contemporary debates concerning sexual difference from a Lacanian psychoanalytic perspective. A new modality of the hysteric's ancient questioning of sexual identity has emerged from the clinic of transgender patients with crucial implications for our understanding of subjectivity today.

The female nude

This thesis argues that a sense of personal power, agency and self-worth can be regained through art practice and will cite examples of this process by artists and others who are outside the parameters of hegemony. The author's experience as a female artist is discussed within the context of historical and contemporary art practices that focus mainly on representations of the female nude, and therefore follows the notion that the personal is political.

How did we ever arrive at the conclusion that teachers are the problem? A critical reading in the discourses of Australian schooling

A Quality Teacher debate is presented within historical and contemporary contexts, including a political history of Australian schooling over the last 20 or so years. It is argued that there is a crisis of confidence in schooling, which is currently being played out by positioning teachers as the 'problem' and not just the 'solution' to this crisis.

Dynamics of cultural heritage development in Sarawak

This paper discusses contestation and legitimization in the heritage process in the Malaysian state of Sarawak. Since 2011 the authors have assisted the Rurum Kelabit Sarawak (RKS) to plan a community museum. The museum is envisaged as an anchor for the preservation and representation of the Kelabit culture. In particular, through consultation and capacity building, the project is seeking to incorporate heritage values into development and cultural tourism plans. The paper considers the roles of historical and contemporary agents in the awakening of heritage consciousness in this community. This process has facilitated questions about priorities including, heritage, tourism, representation and the expression of identity through contemporary design, which this paper will contextualize within the discourse of cultural heritage and development in South East Asia. Apart from the RKS and their range of partners, important agents include the Sarawak Government, with jurisdiction over native customs; the Sarawak Museum Department, an official custodian of cultural heritage; UNESCO, through its promotion of the rights of indigenous people and the integration of culture and development; and the WWF, assisting with the Heart of Borneo conservation project. The authors see this case study of a community museum development process as an opportunity to reflect on the interrelated and contested roles and responsibilities of local, national and trans-national agents in a heritage project that contributes to an understanding of cultural politics and heritage-making.

A proposed definition of the engineering methodology

BACKGROUND An adequately concise and accurate definition of the profession of engineering that can simultaneously encompass a majority of the profession and be reasonably understood by a majority of society arguably remains as an elusive goal yet to be attained.While numerous definitions of the profession exist they tend to describe specific methods or approaches deployed in the practice of engineering rather than be suitably descriptive of the profession of engineering.The lack of an adequate, accurate and relevant definition of the profession of engineering has, and continues to, present disadvantages to the profession. While acknowledging this problem the profession continues to rely on existing inadequate, inaccurate, or irrelevant definitions of itself as it struggles to attain the degree of awareness, recognition, and appreciation of its significant benefits that directly impact society and the individual.Accordingly in many countries the choice of engineering as a career path often ranks below other profession choices such as medicine, law, and management - especially with adolescent girls. Also the relevance and role of professional engineering in socio-economic and socio-political contexts is often undervalued or neglected – especially in national and international policy discussions and development.PURPOSETo provide a clear, concise, and accurate definition of the profession of engineering that is acceptable for most, if not all, major stakeholders.METHOD A review of historical and contemporary definitions of professional engineering is provided. Using Koen’s definition of the engineering method in conjunction with Shulman’s set of characteristics common to professions a more generic definition is derived that seeks to simultaneously accommodate the homogenous multi-disciplinary attributes of professional engineering as well as accommodate the discipline specific attributes.RESULTS A proposed definition of the engineering methodology has been developed. A background introduction and justified derivation is provided for the proposed definition.CONCLUSIONS The limitations and inadequacies of historical and contemporary definitions of professional engineering have been considered. Using Koen’s definition as a basis a more generic multi-disciplinary and more contemporary definition is derived and presented. The goal of the proposed definition of the engineering methodology is to provide a more concise, more accurate, and most importantly a more comprehensible definition of the profession of engineering for the purpose of being applied to all major stakeholders of the profession.

Differing impact of a major biogeographic barrier on genetic structure in two large kangaroos from the monsoon tropics of Northern Australia

Tropical savannas cover 20-30% of the world's land surface and exhibit high levels of regional endemism, but the evolutionary histories of their biota remain poorly studied. The most extensive and unmodified tropical savannas occur in Northern Australia, and recent studies suggest this region supports high levels of previously undetected genetic diversity. To examine the importance of barriers to gene flow and the environmental history of Northern Australia in influencing patterns of diversity, we investigated the phylogeography of two closely related, large, vagile macropodid marsupials, the antilopine wallaroo (Macropus antilopinus; n = 78), and the common wallaroo (Macropus robustus; n = 21). Both species are widespread across the tropical savannas of Australia except across the Carpentarian Barrier (CB) where there is a break in the distribution of M. antilopinus. We determined sequence variation in the hypervariable Domain I of the mitochondrial DNA control region and genotyped individuals at 12 polymorphic microsatellite loci to assess the historical and contemporary influence of the CB on these species. Surprisingly, we detected only limited differentiation between the disjunct Northern Territory and QueenslandM. antilopinus populations. In contrast, the continuously distributedM. robustus was highly divergent across the CB. Although unexpected, these contrasting responses appear related to minor differences in species biology. Our results suggest that vicariance may not explain well the phylogeographic patterns in Australia's dynamic monsoonal environments. This is because Quaternary environmental changes in this region have been complex, and diverse individual species' biologies have resulted in less predictable and idiosyncratic responses.