Epithelial - mesenchymal and mesenchymal - epithelial transitions in carcinoma progression

Like a set of bookends, cellular, molecular, and genetic changes of the beginnings of life mirror those of one of the most common cause of death--metastatic cancer. Epithelial to mesenchymal transition (EMT) is an important change in cell phenotype which allows the escape of epithelial cells from the structural constraints imposed by tissue architecture, and was first recognized by Elizabeth Hay in the early to mid 1980's to be a central process in early embryonic morphogenesis. Reversals of these changes, termed mesenchymal to epithelial transitions (METs), also occur and are important in tissue construction in normal development. Over the last decade, evidence has mounted for EMT as the means through which solid tissue epithelial cancers invade and metastasize. However, demonstrating this potentially rapid and transient process in vivo has proven difficult and data connecting the relevance of this process to tumor progression is still somewhat limited and controversial. Evidence for an important role of MET in the development of clinically overt metastases is starting to accumulate, and model systems have been developed. This review details recent advances in the knowledge of EMT as it occurs in breast development and carcinoma and prostate cancer progression, and highlights the role that MET plays in cancer metastasis. Finally, perspectives from a clinical and translational viewpoint are discussed.

Do repatriate support practices influence repatriate experience, organisational commitment, turnover intentions and perceptions of career success?

The focus of this paper is the development of a model for the effective management of repatriation in multinational enterprises (MNEs). It reviews the literature associated with the relationships between repatriate support practices in relation to repatriation experiences, organisational commitment, turnover intentions, and perceptions of career success. A model has been developed where it is hypothesized that the perception of the provision of important and higher quality practices will result in positive repatriation experiences A positive experience will be positively related to organisational commitment, and perceptions of career success, and negatively related to turnover intentions. These relationships are based on the concepts of social support, uncertainty reduction theory, and psychological contract theory.

Career planning and development in elite sport : an AFL perspective

This paper examines career development in elite sport, specifically the perceptions of Australian Football League (AFL) players on the career development programs offered by the AFL Players Association. HRM literature reveals considerable research in the area of career planning and development. There is however a paucity of research into career planning for elite athletes in Australia. While overseas studies indicate a lack of career planning by elite athletes for their life after sport, that is not the findings of this research. This pilot study reveals that AFL Players not only recognise the need for and value of career planning, they actively utilise the AFL Players Association, Player Development program, in particular the training and development and guidance aspects of the program, This research is useful because it provides feedback to those who formulate such programs to better cater for and create more focused programs. It also provides the basis for further research across the sport and the potential to test its applicability across other elite sports.

Gender issues in the career development of IT professionals: a global perspective

Each period of technological change carries with it high expectations of societal and organizational restructuring that will favour the disadvantaged. The same is true for the Information and Communication Technologies. The fast expansion of the IT labour market, the need for diverse talents, the shift in the demand from technical to more general management and business skills, and the government's and employer's initiatives to improve women's representation in the IT sector created an image that? IT is one of the best-equal opportunity areas 'that provide wider opportunities for women to enter and succeed in this industry'. Nevertheless, the validity of these claims is yet to be established through empirical analysis.

Breaking the cultural mould : the key to women`s career success

This white paper explores the role of organisational culture in either supporting or constraining the success of women in the workplace and investigates the benefits of gender diversity and what organisations can do to prevent ongoing gender bias.