Uomo universale : the imaginary relation between body and mathematic(s) in architecture

What is the role of the human figure in the drawing of the uomo universale? Interlocked with the “master architect” as a constituent component of the canonical bodies of architecture, is the idea of the uomo universale, the universal man, an idea that was especially compelling to Renaissance masters. In contemporary social theory the uomo universale is read for its generic sense as the “universal subject”. Critical to this is a dialectical sense in which “man” confronts its non-neutral association with a gender specificity, either man or woman. This paper looks at the drawing and image of the uomo universale and explores the distinction between presence and representation, between the visibility of the image, its content and detail and the symbolic role of the image as constitutive of a canon of architecture. Though we are not meant to “see” the human figure as corporeal presence and rather focus our attention on the image as a geometric schema, my argument is that only through the figure is the uomo universale engendered as an image of the highest form of nature.

Shelley Hannigan paintings

This exhibition was a part of Geelong’s Momenta! Arts Festival which showcased the arts in Geelong.  Exhibitions were held in shops, galleries, cafes and private residences. My exhibition was held in the Fiona Pickering photographic studio and showroom (now Beavs Bar). Key themes of these works were time, Place and identity.

Hedgehog partial agonism drives warburg-lie metabolism in muscle and brown fat

Diabetes, obesity, and cancer affect upward of 15% of the world’s population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling with altered metabolic state. Exactly which genetic factors define stable metabolic set points in vivo remains poorly understood. Here, we show that hedgehog signaling rewires cellular metabolism. We identify a cilium-dependent Smo-Ca2+-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility. We show that Smo modulators can uncouple the Smo-Ampk axis from canonical signaling and identify cyclopamine as one of a new class of “selective partial agonists,” capable of concomitant inhibition of canonical and activation of noncanonical hedgehog signaling. Intriguingly, activation of the Smo-Ampk axis in vivo drives robust insulin-independent glucose uptake in muscle and brown adipose tissue. These data identify multiple noncanonical endpoints that are pivotal for rational design of hedgehog modulators and provide a new therapeutic avenue for obesity and diabetes.

'Catastrophic failure' theories and disaster journalism : evaluating media explanations of the Black Saturday bushfires

 In recent decades, academic researchers of natural disasters and emergency management have developed a canonical literature on ‘catastrophe failure’ theories such as disaster responses from US emergency management services (Drabek, 2010; Quarantelli, 1998) and the Three Mile Island nuclear power plant (Perrow, 1999). This article examines six influential theories from this field in an attempt to explore why Victoria’s disaster and emergency management response systems failed during Australia’s Black Saturday bushfires. How well, if at all, are these theories understood by journalists, disaster and emergency management planners, and policy-makers? In examining the Country Fire Authority’s response to the fires, as well as the media’s reportage of them, we use the 2009 Black Saturday bushfires as a theory-testing case study of failures in emergency management, preparation and planning. We conclude that journalists can learn important lessons from academics’ specialist knowledge about disaster and emergency management responses.

Colonial girls' literature and the politics of archives in the digital age

In this paper we examine the politics of print and digital archives and their implications for research in the field of historical children's literature. We use the specific example of our comparative, collaborative project 'From Colonial to Modern: Transnational Girlhood in Australian, New Zealand and Canadian Print Cultures, 1840-1940' to contrast the strengths and limitations of print and digital archives of young people's texts from these three nations. In particular, we consider how the failure of some print archives to collect ephemeral or non-canonical colonial texts may be reproduced in current digitising projects. Similarly, we examine how gaps in the newly forged digital "canon" are especially large for colonial children's texts because of the commercial imperatives of many large-scale digitisation projects. While we acknowledge the revolutionary applications of digital repositories for research on historical children's literature, we also argue that these projects may unintentionally marginalise or erase certain kinds of children's texts from scholarly view in the future.

On self-propagating methodological flaws in performance normalization for strength and power sports

Performance in strength and power sports is greatly affected by a variety of anthropometric factors. The goal of performance normalization is to factor out the effects of confounding factors and compute a canonical (normalized) performance measure from the observed absolute performance. Performance normalization is applied in the ranking of elite athletes, as well as in the early stages of youth talent selection. Consequently, it is crucial that the process is principled and fair. The corpus of previous work on this topic, which is significant, is uniform in the methodology adopted. Performance normalization is universally reduced to a regression task: the collected performance data are used to fit a regression function that is then used to scale future performances. The present article demonstrates that this approach is fundamentally flawed. It inherently creates a bias that unfairly penalizes athletes with certain allometric characteristics, and, by virtue of its adoption in the ranking and selection of elite athletes, propagates and strengthens this bias over time. The main flaws are shown to originate in the criteria for selecting the data used for regression, as well as in the manner in which the regression model is applied in normalization. This analysis brings into light the aforesaid methodological flaws and motivates further work on the development of principled methods, the foundations of which are also laid out in this work.

Vesselness features and the inverse compositional AAM for robust face recognition using thermal IR

Over the course of the last decade, infrared (IR) and particularly thermal IR imaging based face recognition has emerged as a promising complement to conventional, visible spectrum based approaches which continue to struggle when applied in the real world. While inherently insensitive to visible spectrum illumination changes, IR images introduce specific challenges of their own, most notably sensitivity to factors which affect facial heat emission patterns, e.g. emotional state, ambient temperature, and alcohol intake. In addition, facial expression and pose changes are more difficult to correct in IR images because they are less rich in high frequency detail which is an important cue for fitting any deformable model. In this paper we describe a novel method which addresses these major challenges. Specifically, to normalize for pose and facial expression changes we generate a synthetic frontal image of a face in a canonical, neutral facial expression from an image of the face in an arbitrary pose and facial expression. This is achieved by piecewise affine warping which follows active appearance model (AAM) fitting. This is the first publication which explores the use of an AAM on thermal IR images; we propose a pre-processing step which enhances detail in thermal images, making AAM convergence faster and more accurate. To overcome the problem of thermal IR image sensitivity to the exact pattern of facial temperature emissions we describe a representation based on reliable anatomical features. In contrast to previous approaches, our representation is not binary; rather, our method accounts for the reliability of the extracted features. This makes the proposed representation much more robust both to pose and scale changes. The effectiveness of the proposed approach is demonstrated on the largest public database of thermal IR images of faces on which it achieved 100% identification rate, significantly outperforming previously described methods

Missing the lesbian and the missing lesbian: a study of the forgotten lesbian in 1970s Australian cinema

This paper addresses the (largely forgotten) presence of lesbians, in 1970s Australian film. It explores the romantic friendships canvassed in 'Picnic at Hanging Rock', (Peter Weir, 1975) and 'The Getting of Wisdom', (Bruce Beresford, 1977) alongside the lesbian in other canonical 1970s works, like the election comedy, 'Don’s Party' (Beresford, 1976) the bio-pic 'Dawn!', and unique tele-features such as 'The Alternative' (Paul Eddy 1978). This paper investigates the way these texts are read and received. The 1970s was an important decade in Australia's filmic history, (affectionately dubbed Australia's film ‘Renaissance’) and this paper examine the lesbian readings that are and aren’t there; and that are and are not avowed.

Negotiating place and space in a school-wide curriculum innovation: a place for the animals

School-wide curriculum innovations are complex fields of practice, held together by a cast of heterogeneous actors who put various and diverse discourses to work in their everyday efforts to shape their work. This paper draws upon ethnographic data collected in a large regional primary school that since the beginning of 2012 has implemented a school-wide science specialism. In this paper, we focus on one feature of the initiative - classroom animals. We explore the discursive construction of ‘classroom animals' in relation to teachers work and student learning, framing our discussion around three dichotomies found in the data that raise questions about: the nature of science education; what it means to be a good teacher in this context; and, what it means to be a good classroom animal. Tensions between canonical, disciplinary approaches to science education and broader, cross-curricular and critical approaches contribute to the broad context of this paper, and implications for embedding science teaching and learning in the everyday work of primary teachers and students are discussed.

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report, for the first time, that the BMP pathway is a positive regulator of muscle mass. Increasing the expression of BMP7 or the activity of BMP receptors in muscles induced hypertrophy that was dependent on Smad1/5-mediated activation of mTOR signaling. In agreement, we observed that BMP signaling is augmented in models of muscle growth. Importantly, stimulation of BMP signaling is essential for conservation of muscle mass after disruption of the neuromuscular junction. Inhibiting the phosphorylation of Smad1/5 exacerbated denervation-induced muscle atrophy via an HDAC4-myogenin–dependent process, whereas increased BMP–Smad1/5 activity protected muscles from denervation-induced wasting. Our studies highlight a novel role for the BMP signaling pathway in promoting muscle growth and inhibiting muscle wasting, which may have significant implications for the development of therapeutics for neuromuscular disorders.

Souveniring the Sydney Opera House

The Sydney Opera House attracts over four million visitors each year to experience its architecture, events and cultural narratives. This experience consciously engages tourists in a constructed spatial encounter, in which the tourist has the opportunity to experience the architecture of this canonical modernist building. This experience often culminates with the purchase of a souvenir, a seemingly innocuous act, but one that is highly revealing of the interrelation between the tourist's experience, the architecture and the souvenir. There has already been much scholarly work on the Sydney Opera House, discussing its architecture, the historical and political context of its commission and its symbolic meaning within the City of Sydney. Less attention however has been paid to the relationship between architecture, experience and memory, as embodied by the souvenir. The tea towels, snow domes, table lights and key rings which depict the Sydney Opera House are, as Celeste Olalquiaga states "static and idealized blueprint... of an experience." This raises debate over what exactly is souvenired; is it the building? The experience? Cultural cachet? What can be revealed about the architecture of the Sydney Opera House, through its souvenirs? Architecture, like souvenirs is party to questions of representation, abstraction and scale. By drawing upon the work of Stewart and Olalquiaga, on the experience of souvenirs, the essay takes an architectural position from which to discuss the way models as objects of architecture and souvenir miniatures are the material representations which commemorate and facilitate a dynamic and ephemeral experience of this building. In this way revealing souvenirs as more than markers of travel, but as Stewart asserts, containers of the cultural narratives, desires and myths, which surround such an iconic architectural destination

The ‘Australian Girl’ and the domestic ideal in colonial women’s fiction

The vast majority of novels and periodicals read by colonial Australian girls were written and published in Britain. ‘Daughters of the Southern Cross’ were more likely to have access to the Girl’s Own Paper by subscription or to imported fictions that had proven popular with British girl readers than any locally produced depictions of girlhood. From the 1880s, however, Australian authors produced several milestone fictions of girlhood for both adult and juvenile audiences. Rosa Praed's An Australian Heroine (1880) and Catherine Martin’s An Australian Girl (1890)  gave voice to the lived experience of Australia for young women, and their publication in Britain contributed to an emergent reciprocal transpacific flow of literary culture.

Two canonical Australian novels that focus on the maturation of girl protagonists who live on bush homesteads were also published in this period. Ethel Turner’s Seven Little Australians (1894) and Miles Franklin’s My Brilliant Career (1901) feature intelligent girls who are not able to be effectively socialised to embrace domesticity. Turner’s Judy Woolcot is distinct among her six siblings as a plucky girl who instigates trouble, while Franklin’s aspiring writer Sybylla Melvyn is informed that ‘girls are the helplessest, uselessest, troublesomest little creatures in the world.’

The 1890s saw an agricultural depression in Australia that only fuelled the urban perpet-uation of the idealised and nationalistic bushman myth in literary and popular culture. The ubiquity of the myth problematised any attempt to situate women heroically within the nation outside of the home. British fictional imaginings of Australian girls lauded their lack of conformity and physical abilities and often showed them bravely defending the family property with firearms. In contrast, Australian domestic fiction, this chapter argues, is unable to accommodate bracing female heroism, postulating ambiguous outcomes at best for heroines who deviate from the feminine ideal.

Judy’s grandmother describes her ‘restless fire’ as something that ‘would either make a noble, daring, brilliant woman of her’, or ‘would flame up higher and higher and consume her’. Turner does not allow Judy’s unconventionality to prosper. Instead, she is killed by a falling gum tree while saving the life of her brother, leaving the future fulfilment of the domestic ideal to her sister, Meg, whose subsequent story occupies Little Mother Meg (1902). Franklin’s Sybylla expresses her inability to be content with the simple pleasures of keeping a home, and this informs her decision to reject a marriage proposal from a wealthy suitor. The novel’s indeterminate conclusion does not allow fulfilment of Sybylla’s writing aspirations, situating her outside the feminine ideal yet not affirming the merits of her desire to reject married life.

While Sharyn Pearce suggests that Judy’s tragic end follows a narrative pattern that sup-ports the glorification of male heroes and renders ‘over-reaching women’ as ‘noble failures’, the novel might also productively be read within the context of other fictions featuring girl protagonists of the period, such as Praed and Martin's novels. This chapter makes the case that Turner and Franklin’s thwarted heroines critique the containment of Australian girls to the banalities of the home by exposing the negative and uncertain outcomes for those who desire the freedoms and aspirations permitted to boys and men. Unlike British fictions that champion adventurous girls, these Australian fictions critique the continuation of gendered restrictions in the colonies by proposing that girls who desire excitement and independence ‘should have been…boy[s]’ (as Sybylla’s mother remarks).

Novel mechanism of Col10a1 nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is a conserved surveillance mechanism that selectively targets mRNA transcripts carrying premature termination codons (PTCs) for rapid degradation in all studied eukaryotes. Mutations that introduce PTCs account for approximately one-third of all inherited genetic disorders, highlighting the importance of NMD in the molecular pathology of many diseases.
The experimental findings presented in this thesis demonstrate that the mechanism of Col10a1 NMD is different to previously described NMD pathways and could represent a failsafe NMD mechanism used by genes that have similar gene structures to COL10A1, which would escape the canonical NMD pathway.

The Janus face of schizotypy: enhanced spiritual connection or existential despair?

It has been asserted that schizotypy has a negative relationship with subjective well-being. By employing a multidimensional measure of spiritual well being with 400 British College students we report a more complex relationship. The Multidimensional Inventory for Religious/Spiritual Well-Being and Schizotypal Personality Questionnaire-Brief Version were used and analysis made use of Canonical Correlational Analysis. Results suggested that two distinct relationships emerged between schizotypy and spirituality. First, a positive association between cognitive/perceptual features of schizotypy and spiritual connectedness emerged. Second a more global negative relationship between feelings of spiritual isolation and despair was found for all aspects of schizotypy. These findings challenge the previous literature based on one-dimensional subjective well being measures which have found only a negative relationship. However, the positive association between connectedness and cognitive-perceptual aspects of schizotypy raises import questions about the possible benefit of certain types of schizotypal experience.