Novel mechanism of Col10a1 nonsense-mediated mRNA decay
Contribuinte(s) |
Bateman, John Lamandè, Shireen |
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Data(s) |
01/02/2014
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Identificador | |
Idioma(s) |
eng |
Publicador |
Deakin University, Faculty of Science, Engineering and Built Environment, School of Life and Environmental Sciences |
Relação |
http://dro.deakin.edu.au/eserv/DU:30067414/fang-licence-2014.pdf http://dro.deakin.edu.au/eserv/DU:30067414/fang-novel-2014A.pdf |
Direitos |
The author |
Tipo |
Thesis |
Resumo |
Nonsense-mediated mRNA decay (NMD) is a conserved surveillance mechanism that selectively targets mRNA transcripts carrying premature termination codons (PTCs) for rapid degradation in all studied eukaryotes. Mutations that introduce PTCs account for approximately one-third of all inherited genetic disorders, highlighting the importance of NMD in the molecular pathology of many diseases.<br />The experimental findings presented in this thesis demonstrate that the mechanism of Col10a1 NMD is different to previously described NMD pathways and could represent a failsafe NMD mechanism used by genes that have similar gene structures to COL10A1, which would escape the canonical NMD pathway. <br /> |
Palavras-Chave | #Nonsense-mediated mRNA decay (NMD) #DNA repair |