The behaviour of US stock prices : evidence from a threshold autoregressive model

This paper investigates the behaviour of US stock prices using an unrestricted two-regime threshold autoregressive (TAR) model with an autoregressive unit root. The TAR model is applied to monthly stock price (NYSE Common Stocks) data for the US for the period 1964:06 to 2003:04. Amongst our main results, we find that the US stock price is a nonlinear series that is characterized by a unit root process, consistent with the efficient market hypothesis.

Overweight children have poor bone strength relative to body weight, placing them at greater risk for forearm fractures

Introduction: Obesity is thought to be a protective factor for bones in adults but not in children based on the evidence of the greater incidence of forearm fractures in obese children. Our objective was to investigate the effect of adiposity on bone strength in relation to the mechanical challenge placed onto the forearm bones in case of a fall.

Methods: Cross sectional areas (CSA) were obtained at the mid- and distal radius by peripheral quantitative computed tomography in 486 children (241 boys), mean age 8.3 years (range 6.9–9.7), participating in the LOOK Project. The following parameters were measured: bone mass and bone CSA (both sites), and muscle and fat CSA (mid-forearm only). Bone strength indices combining bone size and total volumetric density were calculated at each site.

Results/Discussion: Overweight children (BMI > percentile equivalent to 25 kg/m² in adults) have higher bone parameters than normal-weight peers (Z-scores +0.6 to +0.9SD, p < 0.0001). These differences disappear after adjustment for muscle CSA. Adiposity (fat CSA/muscle CSA) was negatively correlated with bone mass, size and strength at the distal radius only (r = −0.1, p < 0.05). After adjustment for body weight (estimate of the load during a fall), the negative correlations were stronger and observed at both the mid- and distal radius (r = −0.37 to −0.55, p < 0.0001).

Conclusion. Overweight children have stronger bones due to greater muscle size. However, children with high fat mass relative to muscle mass (increased adiposity) have poorer bone strength, independent of weight, which may contribute to the increased risk of fracture in obese children.

IgE cross-reactivity between the major peanut allergen Ara h 2 and tree nut allergens

Allergy to peanut and tree nuts is characterised by a high frequency of life-threatening anaphylactic reactions and typically lifelong persistence. Although peanut is the most common cause of nut allergy, peanut allergic patients are frequently also sensitive to tree nuts. It is not known if this is due to cross-reactivity between peanut and tree nut allergens. In this study, the major peanut allergen Ara h 2 was cloned from peanut cDNA, expressed in E. coli cells as a His-tag fusion protein and purified using a Ni-NTA column. Immunoblotting, ELISA and basophil activation indicated by CD63 expression all confirmed the IgE reactivity and biological activity of rAra h 2. To determine whether or not this allergen plays a role in IgE cross-reactivity between peanut and tree nuts, inhibition ELISA was performed. Pre-incubation of serum from peanut allergic patients with increasing concentrations of almond or Brazil nut extract inhibited IgE binding to rAra h 2. Purified rAra h 2-specific serum IgE antibodies also bound to proteins present in almond and Brazil nut extracts by immunoblotting. This indicates that the major peanut allergen, Ara h 2, shares common IgE-binding epitopes with almond and Brazil nut allergens, which may contribute to the high incidence of tree nut sensitisation in peanut allergic individuals.

Construction supply chain economic policy implementation for sectoral change : moving beyond the rhetoric

The improvement of the performance of the construction industry through the improved performance of the supply chains that make up the various sectors is a difficult task and one that has had considerable international debate (London, 2005). The idea of using the supply chain concept as a normative model to improve firm behaviour and thus ultimately industry performance through the development of supply chain clusters or integrated supply chains has been discussed in many public sector policy documents and in the academic research community since the late 1990s (London, 2005). However it has been difficult to see any real examples where this concept has had any major impact – or where the improvements have been measured and/or monitored.

An aqueous Chlorella extract inhibits IL-5 production by mast cells in vitro and reduces ovalbumin-induced eosinophil infiltration in the airway in mice in vivo

An aqueous extract of the edible microalga, Chlorella pyrenoidosa (CP) (1), has recently been tested for its immunomodulatory effects in a human clinical trial. Here, the CP extract was dialyzed and fractionated using Sephadex G 100 chromatography. The effects of a dialyzed aqueous CP extract, fraction 2, on mast cell mediator release in vitro and ovalbumin-induced allergic airway inflammation in vivo were examined. In vitro, treatment of mouse bone marrow-derived mast cells with 2 for 18 h significantly inhibited antigen (trinitrophenyl-BSA)-induced IL-5 production. In vivo, treatment of mice with 2 during ovalbumin sensitization and stimulation process significantly reduced eosinophil and neutrophil infiltration in the airways. Moreover, fractions obtained by size exclusion chromatography of 2 inhibited IgE-dependent cytokine GM-CSF production from human cord blood-derived mast cells. Taken together, these results suggest that 2 is composed of biopolymers with anti-allergic potential.

Do reproductive tactics vary with habitat heterogeneity in the intertidal sea anemone Actinia tenebrosa?

Cnidarians display a diverse range of reproductive tactics including sexual and asexual modes of reproduction. Although few studies have looked for intraspecific variation in reproductive tactics, flexible expression of such life-history traits may be favoured in species that occupy a range of habitats. We tested this in the sea anemone Actinia tenebrosa by comparing cycles of reproductive activity and the mode of production of brooded larvae in local populations occupying boulder fields and stable rock platforms. We determined the mode of production of broods from eight rock platforms (separated by up to 1600 km) and two boulder shores on the south east coast of Australia using a combination of allozyme data and four newly characterised microsatellite markers.

We determined seasonal patterns of brooding and gonad development by monthly dissection of 15–30 adults from each of two boulder fields and two stable platforms. Previous genetic studies have shown that populations of A. tenebrosa on rock platforms can be highly clonal, whereas anemones on more heterogeneous boulder habitats display levels of genotypic diversity similar to that expected for sexual reproduction. We genotyped a total of 221 juveniles from 37 brooding adults including 11 broods and 80 juveniles from boulder shores. We did not detect any evidence of sexual production of broods. All brooded juveniles displayed identical multi-locus genotypes to their brood parent irrespective of habitat of origin or location, including 28 broods (200 juveniles) that were heterozygous at one or more locus. Similarly, we found that temporal patterns of gonad formation and brooding were consistent across habitats and locations. We detected 346 mature males, 234 non-reproductive or immature individuals, and no mature females within a total of 580 dissected individuals. These data suggest that the reproductive tactics of A. tenebrosa are essentially fixed and that variation in the genotypic diversity of populations may reflect variation in factors such as the input of sexually derived planktonically dispersed recruits or post-settlement processes. However, the apparent lack of females paradoxically implies that sexual reproduction, and hence recruitment, must be rare or no longer possible within some populations, and highlights the need for long-term studies of these populations.

Study on thermoplastic-modified multifunctional epoxies : influence of heating rate on cure behaviour and phase separation

The effect of heating rate on the cure behaviour and phase separation of thermoplastic-modified epoxy systems was investigated. Polyethersulphone (PES) modified multifunctional epoxies, triglycidyl-aminophenol (TGAP) and tetraglycidyldiaminodiphenylmethane (TGDDM), as well T300/914 prepreg were used. It was shown that heating rate had a significant influence on the cure kinetics and phase structures of investigated systems. Greater heating rate causes higher epoxy conversion. The domain size of the macrophases formed from phase separation increases with the increase of heating rate. A more complete phase separation is achieved by fast heated thermoplastic-modified epoxy blends.

Life crises on land across the Permian–Triassic boundary in South China

The western Guizhou and eastern Yunnan area of southwest China commands a unique and significant position globally in the study of Permian–Triassic boundary (PTB) events as it contains well and continuously exposed PTB sections of marine, non-marine and marginal-marine origin in the same area. By using a range of high-resolution stratigraphic methods including biostratigraphy, eventostratigraphy, chronostratigraphy and chemostratigraphy, not only are the non-marine PTB sections correlated with their marine counterparts in the study area with high-resolution, the non-marine PTB sections of the study area can also be aligned with the PTB Global Stratotype Section and Point (GSSP) at Meishan in eastern China. Plant megafossils (“megaplants”) in the study area indicate a major loss in abundance and diversity across the PTB, and no coal beds and/or seams have been found in the non-marine Lower Triassic although they are very common in the non-marine Upper Permian. The megaplants, however, did not disappear consistently across the whole area, with some elements of the Late Permian Cathaysian Gigantopteris flora surviving the PTB mass extinction and locally even extending up to the Lower Triassic. Palynomorphs exhibit a similar temporal pattern characterized by a protracted stepwise decrease from fern-dominated spores in the Late Permian to pteridosperm and gymnosperm-dominated pollen in the Early Triassic, which was however punctuated by an accelerated loss in both abundance and diversity across the PTB. Contemporaneous with the PTB crisis in the study area was the peculiar prevalence and dominance of some fungi and/or algae species.

The temporal patterns of megaplants and palynomorphs across the PTB in the study area are consistent with the regional trends of plant changes in South China, which also show a long-term decrease in species diversity from the Late Permian Wuchiapingian through the Changhsingian to the earliest Triassic, with about 48% and 77% losses of species occurring respectively in the end-Wuchiapingian and end-Changhsingian. Such consistent patterns, at both local and regional scales, contradict the hypothesis of a regional isochronous extinction of vegetation across the PTB, and hence call into question the notion that the end-Permian mass extinction was a one-hit disaster. Instead, the data from the study area and South China appears more consistent with a scenario that invokes climate change as the main driver for the observed land vegetation changes across the PTB in South China.

A family of simple and robust finite elements for linear and geometrically nonlinear analysis of laminated composite plates

A family of simple, displacement-based and shear-flexible triangular and quadrilateral flat plate/shell elements for linear and geometrically nonlinear analysis of thin to moderately thick laminate composite plates are introduced and summarized in this paper.

The developed elements are based on the first-order shear deformation theory (FSDT) and von-Karman’s large deflection theory, and total Lagrangian approach is employed to formulate the element for geometrically nonlinear analysis. The deflection and rotation functions of the element boundary are obtained from Timoshenko’s laminated composite beam functions, thus convergence can be ensured theoretically for very thin laminates and shear-locking problem is avoided naturally.

The flat triangular plate/shell element is of 3-node, 18-degree-of-freedom, and the plane displacement interpolation functions of the Allman’s triangular membrane element with drilling degrees of freedom are taken as the in-plane displacements of the element. The flat quadrilateral plate/shell element is of 4-node, 24-degree-of-freedom, and the linear displacement interpolation functions of a quadrilateral plane element with drilling degrees of freedom are taken as the in-plane displacements.

The developed elements are simple in formulation, free from shear-locking, and include conventional engineering degrees of freedom. Numerical examples demonstrate that the elements are convergent, not sensitive to mesh distortion, accurate and efficient for linear and geometric nonlinear analysis of thin to moderately thick laminates.

Self-assembled natural rubber/silica nanocomposites : its preparation and characterization

A novel natural rubber/silica (NR/SiO2) nanocomposite is developed by combining self-assembly and latex-compounding techniques. The results show that the SiO2 nanoparticles are homogenously distributed throughout NR matrix as nano-clusters with an average size ranged from 60 to 150 nm when the SiO2 loading is less than 6.5 wt%. At low SiO2 contents (less-than-or-equals, slant4.0 wt%), the NR latex (NRL) and SiO2 particles are assembled as a core-shell structure by employing poly (diallyldimethylammonium chloride) (PDDA) as an inter-medium, and only primary aggregations of SiO2 are observed. When more SiO2 is loaded, secondary aggregations of SiO2 nanoparticles are gradually generated, and the size of SiO2 cluster dramatically increases. The thermal/thermooxidative resistance and mechanical properties of NR/SiO2 nanocomposites are compared to the NR host. The nanocomposites, particularly when the SiO2 nanoparticles are uniformly dispersed, possess significantly enhanced thermal resistance and mechanical properties, which are strongly depended on the morphology of nanocomposites. The NR/SiO2 has great potential to manufacture medical protective products with high performances.

Sustaining human carrying capacity : a tool for regional sustainability assessment

Regional sustainability is an important focus for natural resource management. Measuring how social and economic systems are progressing to sustainability is therefore a critical need. But it is dependent upon the development of analytical and methodological tools to measure progress, particularly, we argue, at the regional level. Achieving sustainability at the regional scale is important since it's at this scale where social institutions and ecological functioning are most closely linked. However, our recent study that evaluated the effectiveness of current sustainability assessment methods at the regional scale found methods developed for the global, national and state scales are not entirely effective at assessing sustainability at this spatial scale. Following on from this critique, we developed and tested a new method for assessing sustainability, which we believe is applicable at the regional scale. The framework, Sustaining Human Carrying Capacity (SHCC), evaluates the sustainability of regional human activities by considering the pressures these activities have on regional ecosystems. SHCC was tested and evaluated at the regional scale, demonstrating its potential to be an effective method for monitoring sustainability. It also has potential to be used to inform the community and decision makers about the sustainability of their region, and help guide strategic planning to progress sustainability.

Nanohydroxyapatite coating on a titanium–niobium alloy by a hydrothermal process

A novel one-step hydrothermal coating process was used to produce nanohydroxyapatite (nano-HA) coating on a titanium–niobium (TiNb) alloy substrate in a newly designed solution containing calcium and phosphate ions. The morphology of the coating was studied using scanning electron microscopy. The phase identification of the coating was carried out using X-ray diffraction, attenuated total reflectance Fourier transform infrared spectroscopy and transmission electron microscopy. The reaction between the surface of TiNb alloy and the solution during the hydrothermal process was studied by Xray photoelectron spectroscopy. Results show that the coating formed on the surface of TiNb alloy was composed of nano-HA particles. During the hydrothermal process, TiO₂ and Nb₂O₅ formed on the TiNb alloy surface and hydrated to Ti(OH)4 and Nb(OH)₅, respectively. Calcium phosphate nucleated and grew into a layer of nano-HA particles on the surface of TiNb alloy under the hydrothermal conditions. The crystallinity of the nano-HA coating was improved with the increase in hydrothermal treatment temperature and time duration. Nano-HA coating with good crystallinity was produced on the TiNb alloy via the hydrothermal process at a temperature of 200 ºC for 12 h.

A controlled analysis of professionals' contemporaneous notes of interviews about alleged child abuse

Objective : The current study investigated (under optimal conditions) the accuracy and completeness of professionals’ contemporaneous written notes of child abuse interviews.
Method : Participants included 107 experienced child abuse investigators who were all trained to adhere to best-practice interview guidelines and who routinely took notes as records of interviews. The interviews documented for this study were read live for 15 min duration, and at a pace of 2.2 words (on average)/s. The professionals’ notes of the interviews were analyzed for completeness and accuracy. Key outcome measures were the prevalence and discernability of the questions (i.e., whether the structure of questions was recorded accurately) as well as the child responses.
Results : Despite the omission of 39% of abuse-related details, recording of content details was clearly prioritized over interviewer questions. This was revealed irrespective of the measure of note taking quality or the quality of the interview being recorded. Of the various layout styles employed, scrutiny of interviewer questions was maximized by: (a) using symbols or spacing to delineate questions and responses, (b) capturing the first two words of a question, and (c) using abbreviations.
Conclusions : Although note taking could potentially improve with further research, training and instruction, this form of documentation does not provide full scrutiny of the interview process, even under optimal conditions.
Practice implications : Electronic recording is strongly recommended for all interviews, especially considering global concerns about interviewers’ adherence to best-practice interview guidelines. If notes continue to be used as a record of interview, further research and training are urgently warranted to improve note taking competency.