Descripción de la estructura organizacional del área de responsabilidad empresarial de Ecopetrol

Este artículo tiene como objetivo documentar, mediante el uso de la descripción, el funcionamiento y desarrollo estructural del área de responsabilidad social empresarial de la compañía colombiana de petróleos Ecopetrol S.A. El trabajo se fundamenta a partir de la definición de variables como: Historia y evolución del área, plataforma estratégica, división y coordinación de trabajo. Realizando esta detallada descripción, un análisis de su funcionamiento y buscando una comprensión de sus relaciones con todas las demás divisiones de la empresa; así como, un entendimiento de la sinergia con sus grupos de interés, se conocerán los impactos que genera. Con ello se puede organizar un marco descriptivo que permita aclarar la actividad de un área de RSE; examinando los paralelos con otras empresas que harán posible, en un futuro, entender los modelos de creación y funcionamiento para otras compañías.

Structural Crystallography Development in the 20th Century. Impact in the Biomedical Sciences and Perspectives in this Field

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Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria

Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting many synthetic strategies for improving the immunogenicity properties of these sequences, the approach consisting of identifying high binding motifs present in those, and then performing specific changes on amino-acids belonging to such motifs, has proven to be a workable strategy. In addition, other strategies consisting of chemically introducing non-natural constraints to the backbone topology of the molecule and modifying the a-carbon asymmetry are becoming valuable tools to be considered in this pursuit. Non-natural structural constraints to the peptide backbone can be achieved by introducing peptide bond isosters such as reduced amides, partially retro or retro-inverso modifications or even including urea motifs. The second can be obtained by strategically replacing L-amino-acids with their enantiomeric forms for obtaining both structurally site-directed designed immunogens as potential vaccine candidates and their Ig structural molecular images, both having immunotherapeutic effects for preventing and controlling malaria.

Transfer of knowledge of the structural components of the model Q400 and Global Express: the case of Aerospace Bombardier, Querétaro

The aim of this paper is to analyze the knowledge transfer in the production of structural components of two aircraft:Q400 and Global Express of Bombardier Aerospace Company, Querétaro. Bombardier Aerospace is a pioneer company in the aviation sector in Mexico, and the third largest civil aircraft manufacturer. In 2005, Bombardier decided to invest in Mexico, creating Bombardier Aerospace de Mexico S. A. C. V. and transferring production lines from Japan and Toronto to Queretaro. The relocation strategy of both plants aims to reduce modular and general production costs facing other competitors. The relocation has been supported by the State Government funds, through a trust and the creation of Queretaro aerospace cluster. Among various benefits, the State of Queretaro donated seventy-eight acres of land where the Queretaro International Airport (QIA) and a training centre will be built to promote the development of this sector. The interest in this research is to analyze and describe the transfer of knowledge to the production of structural components of both aircraft models, thanks to the results of productivity and internal and external factors which have contributed along with this transfer