Towards an Integrative Information Society: Studies on Individuality in Speech and Sign

The flow of information within modern information society has increased rapidly over the last decade. The major part of this information flow relies on the individual’s abilities to handle text or speech input. For the majority of us it presents no problems, but there are some individuals who would benefit from other means of conveying information, e.g. signed information flow. During the last decades the new results from various disciplines have all suggested towards the common background and processing for sign and speech and this was one of the key issues that I wanted to investigate further in this thesis. The basis of this thesis is firmly within speech research and that is why I wanted to design analogous test batteries for widely used speech perception tests for signers – to find out whether the results for signers would be the same as in speakers’ perception tests. One of the key findings within biology – and more precisely its effects on speech and communication research – is the mirror neuron system. That finding has enabled us to form new theories about evolution of communication, and it all seems to converge on the hypothesis that all communication has a common core within humans. In this thesis speech and sign are discussed as equal and analogical counterparts of communication and all research methods used in speech are modified for sign. Both speech and sign are thus investigated using similar test batteries. Furthermore, both production and perception of speech and sign are studied separately. An additional framework for studying production is given by gesture research using cry sounds. Results of cry sound research are then compared to results from children acquiring sign language. These results show that individuality manifests itself from very early on in human development. Articulation in adults, both in speech and sign, is studied from two perspectives: normal production and re-learning production when the apparatus has been changed. Normal production is studied both in speech and sign and the effects of changed articulation are studied with regards to speech. Both these studies are done by using carrier sentences. Furthermore, sign production is studied giving the informants possibility for spontaneous speech. The production data from the signing informants is also used as the basis for input in the sign synthesis stimuli used in sign perception test battery. Speech and sign perception were studied using the informants’ answers to questions using forced choice in identification and discrimination tasks. These answers were then compared across language modalities. Three different informant groups participated in the sign perception tests: native signers, sign language interpreters and Finnish adults with no knowledge of any signed language. This gave a chance to investigate which of the characteristics found in the results were due to the language per se and which were due to the changes in modality itself. As the analogous test batteries yielded similar results over different informant groups, some common threads of results could be observed. Starting from very early on in acquiring speech and sign the results were highly individual. However, the results were the same within one individual when the same test was repeated. This individuality of results represented along same patterns across different language modalities and - in some occasions - across language groups. As both modalities yield similar answers to analogous study questions, this has lead us to providing methods for basic input for sign language applications, i.e. signing avatars. This has also given us answers to questions on precision of the animation and intelligibility for the users – what are the parameters that govern intelligibility of synthesised speech or sign and how precise must the animation or synthetic speech be in order for it to be intelligible. The results also give additional support to the well-known fact that intelligibility in fact is not the same as naturalness. In some cases, as shown within the sign perception test battery design, naturalness decreases intelligibility. This also has to be taken into consideration when designing applications. All in all, results from each of the test batteries, be they for signers or speakers, yield strikingly similar patterns, which would indicate yet further support for the common core for all human communication. Thus, we can modify and deepen the phonetic framework models for human communication based on the knowledge obtained from the results of the test batteries within this thesis.

New [18F]Tracers for Alzheimer's Disease Imaging. Labeling Synthesis And Biological Testing

Alzheimer’s disease (AD) is the most common form of dementia. Characteristic changes in an AD brain are the formation of β-amyloid protein (Aβ) plaques and neurofibrillary tangles, though other alterations in the brain have also been connected to AD. No cure is available for AD and it is one of the leading causes of death among the elderly in developed countries. Liposomes are biocompatible and biodegradable spherical phospholipid bilayer vesicles that can enclose various compounds. Several functional groups can be attached on the surface of liposomes in order to achieve long-circulating target-specific liposomes. Liposomes can be utilized as drug carriers and vehicles for imaging agents. Positron emission tomography (PET) is a non-invasive imaging method to study biological processes in living organisms. In this study using nucleophilic 18F-labeling synthesis, various synthesis approaches and leaving groups for novel PET imaging tracers have been developed to target AD pathology in the brain. The tracers were the thioflavin derivative [18F]flutemetamol, curcumin derivative [18F]treg-curcumin, and functionalized [18F]nanoliposomes, which all target Aβ in the AD brain. These tracers were evaluated using transgenic AD mouse models. In addition, 18F-labeling synthesis was developed for a tracer targeting the S1P3 receptor. The chosen 18F-fluorination strategy had an effect on the radiochemical yield and specific activity of the tracers. [18F]Treg-curcumin and functionalized [18F]nanoliposomes had low uptake in AD mouse brain, whereas [18F]flutemetamol exhibited the appropriate properties for preclinical Aβ-imaging. All of these tracers can be utilized in studies of the pathology and treatment of AD and related diseases.

Central auditory processing and the acquisition of phonology in 2-year-old children with recurrent acute otitis media

Middle ear infections (acute otitis media, AOM) are among the most common infectious diseases in childhood, their incidence being greatest at the age of 6–12 months. Approximately 10–30% of children undergo repetitive periods of AOM, referred to as recurrent acute otitis media (RAOM). Middle ear fluid during an AOM episode causes, on average, 20–30 dB of hearing loss lasting from a few days to as much as a couple of months. It is well known that even a mild permanent hearing loss has an effect on language development but so far there is no consensus regarding the consequences of RAOM on childhood language acquisition. The results of studies on middle ear infections and language development have been partly discrepant and the exact effects of RAOM on the developing central auditory nervous system are as yet unknown. This thesis aims to examine central auditory processing and speech production among 2-year-old children with RAOM. Event-related potentials (ERPs) extracted from electroencephalography can be used to objectively investigate the functioning of the central auditory nervous system. For the first time this thesis has utilized auditory ERPs to study sound encoding and preattentive auditory discrimination of speech stimuli, and neural mechanisms of involuntary auditory attention in children with RAOM. Furthermore, the level of phonological development was studied by investigating the number and the quality of consonants produced by these children. Acquisition of consonant phonemes, which are harder to hear than vowels, is a good indicator of the ability to form accurate memory representations of ambient language and has not been studied previously in Finnish-speaking children with RAOM. The results showed that the cortical sound encoding was intact but the preattentive auditory discrimination of multiple speech sound features was atypical in those children with RAOM. Furthermore, their neural mechanisms of auditory attention differed from those of their peers, thus indicating that children with RAOM are atypically sensitive to novel but meaningless sounds. The children with RAOM also produced fewer consonants than their controls. Noticeably, they had a delay in the acquisition of word-medial consonants and the Finnish phoneme /s/, which is acoustically challenging to perceive compared to the other Finnish phonemes. The findings indicate the immaturity of central auditory processing in the children with RAOM, and this might also emerge in speech production. This thesis also showed that the effects of RAOM on central auditory processing are long-lasting because the children had healthy ears at the time of the study. An effective neural network for speech sound processing is a basic requisite of language acquisition, and RAOM in early childhood should be considered as a risk factor for language development.

JOHTAMISOPIT KUNTAORGANISAATIOSSA – diskursiivinen tutkimus sosiaali- ja terveystoimesta 1980-luvulta 2000-luvulle

Julkisen sektorin johtamista on uudistettu viime vuosikymmeninä uuden julkisjohtamisen suuntauksen kautta. Tässä keskeistä ovat olleet markkinamekanismin sekä yksityissektorin johtamisoppien soveltaminen julkiselle sektorille. Tämän tutkimuksen tarkoituksena on tuottaa tietoa johtamisoppien soveltamisesta kuntaorganisaation sosiaalija terveystoimessa. Mielenkiinnon kohteena ovat kysymykset, miten johtamisopit ovat tulleet kuntaorganisaatioon ja miten ne ovat levinneet, rakentuneet sekä rakentaneet kontekstiaan tarkasteluajanjaksolla 1985 - 2007. Tutkimuksen lähestymistapa on diskurssianalyyttinen ja nojaa epistemologialtaan tulkinnallisesta tieteen filosofiasta nousseeseen sosiaaliseen konstruktivismiin. Oppien leviämistä tarkastellaan tässä tutkimuksessa translaationa, kääntämisprosessina, jossa opin johtoportaaseen tullut ensimmäinen versio tulkitaan ja käännetään organisaation kielelle ja käytännöiksi. Oppien rakentumista kontekstissaan käsitteellistetään sedimentoitumisen käsitteen kautta, mikä auttaa ymmärtämään uusien ja vanhojen oppien elementtien kerrostumista lähes muuttumattomista syvärakenteista nopeasti muuttuviin pintarakenteisiin. Tutkimuksen kohdeorganisaationa on suomalainen, keskikokoinen kuntaorganisaatio. Aineistona on käytetty kirjallisia dokumentteja ja haastatteluja. Johtamisoppeja kuntaorganisaatioon välittäviä tahoja ovat olleet konsulttiyritykset, yliopistot, kuntien johtoportaan verkostot, uudet johtajat sekä koulutuspäivät. Organisaation valmius uuden johtamisopin omaksumiseen on yhteydessä organisaatioon, johtoon, tarjolla oleviin oppeihin sekä toimintaympäristöön liittyviin tekijöihin Levitäkseen organisaatiossa oppi tarvitsee johdon tasolta kannattajan, joka markkinoi sitä muulle virkamies- ja luottamushenkilöjohdolle. Kun oppi saavuttaa johdon enemmistön tuen, käynnistyy sen kääntämisprosessi johdon puheesta henkilöstön puheen ja käytäntöjen tasolle. Uudet johtamisopit kyseenalaistavat vanhoja ”totuuksia” ja samalla ne määrittävät, mikä on tärkeää ja mikä jää huomiotta. Uudet opit eivät syrjäytä kokonaan vanhoja, vaan opit sedimentoituvat: vanhojen oppien diskursiivisia elementtejä jää pois ja uusien oppien elementtejä tulee mukaan johtamispuheeseen. Johtamisopit rakentavat kontekstiaan sekä puheen, käytäntöjen että organisaatiorakenteiden tasolla, mutta joihinkin syvärakenteisiin ne eivät ole pystyneet vaikuttamaan tai vaikuttavat äärimmäisen hitaasti. Asiakaslähtöisyys muun muassa on ollut useimpien johtamisoppien diskursiivinen elementti, mutta se on jäänyt toistuvasti kuntaorganisaation sosiaali- ja terveystoimessa organisaatiolähtöisen palvelujen järjestämistavan ja talouden kautta tapahtuvan tuloksellisuuden arvioinnin varjoon. Diskurssit muutoksesta ja sen välttämättömyydestä, tehokkuudesta sekä julkisen rinnastaminen yksityiseen näyttäytyivät tässä tutkimuksessa metatason diskursseina, jotka oikeuttavat yksityiseltä sektorilta lähtöisin olevien johtamisdiskurssien soveltamisen muutoksen ja tehokkuuden aikaansaamiseksi julkiselle sektorille. Kuntien sosiaali- ja terveystoimen tuloksellisuuden ja tehokkuuden arviointi on kapeutunut liikkeenjohdon peruslähtökohdista nousevaksi talouden kautta tapahtuvaksi arvioinniksi. Tässä julkisen toiminnan omiin arvolähtökohtiin ja teoriataustaan pohjautuvien toiminnan tulosten ja saavutettujen hyvinvointivaikutusten arviointi sekä näistä kertovien mittarien kehittäminen yhdessä talouden mittarien kanssa on marginaaliin jäänyttä, mutta nousevaa puhetta.

Cognitive Development of Very Low Birth Weight Children from Infancy to Pre-school Age

The survival of preterm born infants has increased but the prevalence of long-term morbidities has still remained high. Preterm born children are at an increased risk for various developmental impairments including both severe neurological deficits as well as deficits in cognitive development. According to the literature the developmental outcome perspective differs between countries, centers, and eras. Definitions of preterm infant vary between studies, and the follow-up has been carried out with diverse methods making the comparison less reliable. It is essential to offer parents upto-date information about the outcome of preterm infants born in the same area. A centralized follow-up of children at risk makes it possible to monitor the consequences of changes in the treatment practices of hospitals on developmental outcome. This thesis is part of a larger regional, prospective multidisciplinary follow-up project entitled “Development and Functioning of Very Low Birth Weight Infants from Infancy to School Age” (PIeniPAinoisten RIskilasten käyttäytyminen ja toimintakyky imeväisiästä kouluikään, PIPARI). The thesis consists of four original studies that present data of very low birth weight (VLBW) infants born between 2001 and 2006, who are followed up from the neonatal period until the age of five years. The main outcome measure was cognitive development and secondary outcomes were significant neurological deficits (cerebral palsy, CP, deafness, and blindness). In Study I, the early crying and fussing behavior of preterm infants was studied using parental diaries, and the relation of crying behavior and cognitive and motor development at the age of two years was assessed. In Study II, the developmental outcome (cognitive, CP, deafness, and blindness) at the age of two years was studied in relation to demographic, antenatal, neonatal, and brain imaging data. Development was studied in relationship to a full-term born control group born in the same hospital. In Study III, the stability of cognitive development was studied in VLBW and full-term groups by comparing the outcomes at the ages of two and five years. Finally, in Study IV the precursors of reading skills (phonological processing, rapid automatized naming, and letter knowledge) were assessed for VLBW and full-term children at the age of five years. Pre-reading skills were studied in relation to demographic, antenatal, neonatal, and brain imaging data. The main findings of the thesis were that VLBW infants who fussed or cried more in the infancy were not at greater risk for problems in their cognitive development. However, crying was associated with poorer motor development. The developmental outcome of the present population was better that has been reported earlier and this improvement covered also cognitive development. However, the difference to fullterm born peers was still significant. Major brain pathology and intestinal perforation were independent significant risk factors for adverse outcome, also when several individual risk factors were controlled for. Cognitive development at the age of two years was strongly related with development at the age of five years, stressing the importance of the early assessment, and the possibility for early interventions. Finally, VLBW children had poorer pre-reading skills compared with their full-term born peers, but the IQ was an important mediator even when children with mental retardation were excluded from the analysis. The findings suggest that counseling parents about the developmental perspectives of their preterm infant should be based on data covering the same birth hospital. Neonatal brain imaging data and neonatal morbidity are important predictors for developmental outcome. The findings of the present study stress the importance of both short-term (two years) and long-term (five years) follow-ups for the individual, and for improving the quality of care.